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Biomedical subjects

V Pegram

Publications and source records attributed to V Pegram.

12 recordsLinked to original sources
PubMed1994

A laboratory validation study of a portable system for remote recording of sleep-related respiratory disorders.

This study represents the validation of an out-of-laboratory recording system for screening sleep disorders by comparing it to an in-laboratory system which accomplishes complete polysomnography. Forty patient cases were collected. Each patient slept in the sleep laboratory with the simultaneous monitoring of eight channels from the Sleep I/T (CNS, Inc), as well as complete polysomnographic monitoring comparable to that which accomplishes routine patient evaluations utilizing the Sleeplab (CNS, Inc) system. The data collected on the Sleeplab system were analyzed in a computer-assisted manner followed by manual overreading of the raw data. The Sleep I/T data analysis was performed automatically using default parameters. The results revealed no significant differences in the determination of sleep efficiency, respiratory disturbance index (RDI), periodic leg movement (PLM) index, or the desaturation index. For the RDI, the sensitivity was 100 percent and the specificity was 93 percent for correctly detecting an RDI of 15 per hour, and the PLM index had a sensitivity of 89 percent and specificity of 97 percent in detecting episodes greater than 20 per hour. These data demonstrate excellent agreement between this out-of-laboratory system and polysomnography in its ability to detect accurately RDI, PLM index, and saturation levels.

Humans↗
PubMed1990

Prognostic significance of age and tonsillectomy in uvulopalatopharyngoplasty.

The objective of this study was to analyze the results of uvulopalatopharyngoplasty on 133 adult patients with sleep apnea. This group of patients was subjected to computer analysis by a statistician. Two previously unreported observations were revealed: There was a straight line decline in measurable improvement with advancing age so, by age 60, there were no patients with improvement; and patients who had tonsillectomy as a part of the uvulopalatopharyngoplasty had a markedly increased success rate compared to those who did not have tonsils. These two previously unreported observations might have significance and value in establishing guidelines for preoperative prognostic predictions of success.

Adult↗
PubMed1980

Chronic use of triazolam: the effects on the sleep patterns of insomniacs.

The present study was designed to evaluate the effects of triazolam 0.5 mg on the sleep of insomniac patients when given for 3 weeks. The results showed that both acute and chronic triazolam administration are effective in decreasing sleep latency, increasing sleep duration, increasing sleep efficiency and decreasing total wake time without producing major effects on sleep staging. Sleep Stages 1 and 2 were significantly altered by drug treatment but in a positive direction. This change is primarily attributable to the significant decrease in sleep onset. Deep sleep and REM were not significantly changed during triazolam treatment nor was there any evidence of REM rebound after discontinuation of the medication. It was noted that some of the sleep parameters measured shifted toward baseline measures in the first night after triazolam treatment was terminated. However, the total recovery period recorded (7 days) showed the quality and quantity of sleep obtained to be improved over baseline measures. The recovery data compared favourably with those improvements noted during chronic administration of triazolam. It was also found that 3 weeks of triazolam 0.5 mg usage did not result in tolerance to its hypnotic properties. Thus, triazolam maintains its hypnotic effectiveness throughout 3 weeks of administration.

Adolescent↗
PubMed1975

The sleep of the baboon, Papio papio, under natural conditions and in the laboratory.

The sleep pattern of sixteen baboons (Papio papio) was studied under two very different conditions: (1) in a laboratory at Marseilles, the monkey being immobilized in a restraining chair in a soundproof cubicle; (2) in an African reserve, the monkey being housed in a large cage placed in its natural environment. Some very marked differences emerged. Sleep in the laboratory was longer (by 24 min) and richer in stage 3 and paradoxical sleep. In Africa, however, the sleep showed much more stage 1, was more fragmented and stages 2 and 3 and paradoxical sleep episodes were of shorter duration. Records made in Africa indicate that sleep is independent of slight environmental changes (day length, brightness of the moon, variations in temperature, calls of predators). But the comparison of the two series of results reveals the reorganization which occurs when the monkey is exposed to such different conditions. This adaptation to the environment affects, unequally, the various slow sleep stages and paradoxical sleep. In fact, the major modifications occur in stages 1 and 3 of slow sleep and in paradoxical sleep, while stage 2 appears to constitute the stable, unmodifiable nucleus of sleep.

Animals↗