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Biomedical subjects

V Pazderka

Publications and source records attributed to V Pazderka.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Changes of articular cartilage in coxarthrosis].

In cases of advanced coxarthrosis indicated for total endoprosthesis [a total of 216 observations made] the most frequent changes included cases of lowering, defibration or even complete abrasion of cartilage in the most exposed segment of the articular head [196x]. Small patches of connective cartilage [133x] were found in the areas of abrasion. There were rare cases of chondrocyte nests as a manifestation of proliferation [25x]. The usual picture of coxarthrosis had exceptions in the form of flatly worn-out surface areas (34X) and pannus (7X). These may have been cases of secondary coxarthrosis accompanying some other, clinically overlooked, underlying process.

Biopsy↗
PubMed1976

Fibroblast lysis by lymphocytes from normal persons and SLE patients on short-term cultures.

Lymphocytes from thirty-six normal individuals of both sexes with ages ranging from 4-89 years were tested for their cytotoxic activity against short term cluters of fibroblasts from nine foetal umbilical cords and nine adult skin samples. Wide variability in the amount of fibroblast lysis was observed. Adult male lymphocytes caused significantly higher lytic activity than lymphocytes of adult females against both types of targets. Cell-mediated target cell reduction was not confined to allogeneic target cells. There was also killing of autochthonous cultured fibroblasts. Some individuals' sera inhibited the fibroblast lytic activity of their own lymphocytes. These cell-mediated reactions are directed against unknown antigenic specifications, probably not histocompatibility antigens, and give evidence of the problem of how to measure normal controls in the microcytotoxicity test in allogeneic human testing. Both autochthonous and allogeneic target cell lysis were also observed in SLE patients.

Adolescent↗
PubMed1975

[Differentiation of spondylitis ankylopoietica and spondylitis hyperostotica].

Changes in the bodies of vertebrae in ancylopoetic spondylitis (Bekhterev's disease) and in hyperostotic spondylitis (Forestier's disease) may be very similar, in particular as regards the ancylotic connection of the bodies of the vertebrae and syndesmophytes. In the differential diagnosis the following differences are important: Syndesmophytes in Bekhterev's disease are symetrical and continuous, there is ossification of the intervertebral discs, and ancylosis affects always sacroiliac, intervertebral and costovertebral joints. In hyperostotic spondylosis the sclerotic syndesmophytes bulge in a lateral direction, mainly to the right. The inveretebral discs do not ossify, the sacroilliac and other above mentioned joints are not affected.

Aged↗