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Biomedical subjects

V Parker

Publications and source records attributed to V Parker.

At least 37 records · Page 2Linked to original sources

Cot deaths and water-sodium.

Over a thirty-year period in Scunthorpe, during which there were two changes in the sodium content of the water supply, there were significantly more sudden deaths in infancy during the decade when sodium levels were highest. This is compatible with the hypothesis that hypernatraemia is a factor leading to cot death. Changes in the incidence of breastfeeding over the same period may have contributed to, but are unlikely to account for, the result because the pattern was different in a neighbouring district where there was no change in water quality.

Animals↗

Excretion of non-conjugated androstenedione and testosterone in human urine.

A method for the measurement of unconjugated testosterone and androstenedione in human urine is described. The method uses chromatographic separation followed by radioimmunoassay and has been examined for reliability. The mean 24-hour excretion of androstenedione by adult male subjects was 2.5 mug and of testosterone was 0.8 mug. For women, the mean excretion was 2.9 mug of androstenedione and 0.25 mug of testosterone. In pregnancy, androstenedione excretion was occasionally elevated above the normal range, but testosterone excretion was quite commonly increased. Some hirsute subjects exhibited an increase in androstenedione excretion, which was decreased by administration of dexamethasone. The results suggest that the amount of unconjugated testosterone in urine is not a direct reflection of the plasma free testosterone, but urinary androstenedione may be a useful reflection of plasma androstenedione levels.

Adult↗

Genetic analysis of heterogeneous DNA circles formed after prophage Mu induction.

Induction of a Mu prophage in Escherichia coli Hfr strains lyosgenic for Mu cts62 leads to the generation of F' episomes. Each episome thus formed carries at least one copy of the Mu genome. These results suggest that integration of Mu is mandatory for the formation of the heterogeneous circles during the lytic cycle. The circles may be precursors for phage maturation.

Coliphages↗

Oliver Wendell Holmes. Man of Medicine; Man of Letters.

This biographical sketch portrays Oliver Wendell Holmes as a leading figure both in American medicine and in American literature. Particular attention is directed to his classic essay, "The Contagiousness of Puerperal Fever."

History, 19th Century↗

Deficits in exploratory behaviour in socially isolated rats are not accompanied by changes in cerebral cortical adrenoceptor binding.

Social isolation of rats produces marked deficits in exploratory behaviour in a novel environment. To test our hypothesis that adrenoceptors are modified by social isolation we have measured alpha 2- and beta-adrenoceptor binding in the cerebral cortex of rats isolated for 21 days starting immediately after weaning. After this period the animals showed a significant reduction in exploration in the elevated X-maze and increased avoidance of bright light in a two-compartment shuttlebox. There were no changes in adrenoceptor binding at this time, however. The implications of these findings are discussed.

Animals↗

The relation of ethnic identification with cigarette smoking among US urban African American and Latino youth: a pilot study.

Primarily African American and Latino seventh graders (N = 545) attending health and science classes at three urban Southern California junior high schools were administered a 13-item ethnic identification assessment during one class period, to investigate the relationship between ethnic identification and tobacco use. For African Americans, the perception of looking different from other ethnic groups was found to be associated with avoidance of peer tobacco use. Among Latinos, the perception of being liked by other ethnic groups, and enjoying interaction with people outside of their ethnic group, were found to be associated with negating peer influence for tobacco use. Watching television shows with main characters of same ethnic group was associated with being able to make friends without using tobacco, for both ethnic groups. For Latinos, ever trying a cigarette was associated with the perception of being liked by other ethnic groups. These results suggest there may be elements inherent in ethnic identification protective against peer influence for smoking among ethnic minority youth. Also, acculturation of Latinos to the majority population may increase their risk for experimentation with tobacco products.

Adolescent↗