Glucose-6-phosphate dehydrogenase deficiency. Part 2. Tropical Asia.
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Biomedical subjects
Publications and source records attributed to V Panich.
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Erythrocyte G6PD from 1157 nondeficient Thai males was studied electrophoretically. The enzyme from four subjects showed abnormal mobility. Characterization of the enzyme revealed three new variants: G6PDs Ayutthaya (n = 2), S-Sakorn, and Chao Phya.
The incidence of G6PD deficiency among 338 Thai males with senile cataracts was 5.92% while 446 control Thai males gave an incidence of 6.95%. The figures in females were 16.29% and 14% among 201 senile cataracts females and 200 control females respectively. The age of onset of senile cataracts was not different between the G6PD deficient and G6PD normal groups. The findings indicate that, at least in Thailand, G6PD deficiency in general is not a factor in cataractogenesis.
7 out of 534 South Vietnamese males showed erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, giving a 1.31% incidence of G-6-PD deficiency. Partially purified erythrocyte enzyme was studied in 6 of the 7 G-6-PD deficient males. Three variants were found: G-6-PD Mahidol (3), Canton (2), and Long Xuyen (1).
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Partial purified erythrocyte G-6-PD from 25 G-6-PD deficient southern Chinese male residents in Thailand was characterized. Five G-6-PD variants were found : G-6-PDs Canton (8), Dhon (or Taipei-Hakka) (8), Mahidol (or B (-) Chinese) (6), Haad Yai (1), and Hong Kong (1). One person whose enzyme was not fully characterized might have G-6-PD Haad Yai or a new variant.
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