Deliberate inhalation of volatile substances is a common and harmful practice among young persons worldwide. Recently, we described chromosome damage in children who chronically inhale volatile agents. Clinical and cytogenetic studies were performed for 15 "sniffing" children (13 boys and 2 girls), the purpose of which was to define the chromosomal effect of the acute intoxication. A significant increase in the rate of chromosome abnormalities and in the frequency of sister chromatid exchanges (SCEs) was found in sniffers vs. controls. The values were also higher in children who were acutely intoxicated than in those who chronically inhaled volatile agents. Clinical, socioeconomic, and cytogenetic findings are also discussed.

Adolescent↗

PubMedDate not supplied

Evoked potentials in brain death. A critical review.

The development of transplant surgery has determined the necessity to revise criteria and to apply new electrophysiologic techniques to add further informations when survival of brain function is in question. The EPs, which provide a sensitive tool for assessment of integrity of main sensorial systems, could have a place in the electrophysiologic evaluation of the brain death. This review deals with the role of EPs in brain death and points out the main patterns found in that clinical condition.

Adult↗

PubMedDate not supplied

Antiphospholipid antibodies in young adults with cerebrovascular ischemic disease.

In this survey we reviewed some of the most recent laboratory and clinical studies on cerebral ischemia in young patients with antiphospholipid antibodies (aPLs). A strong association between aPLs and cerebrovascular ischemic disease has been documented, but the underlying pathogenetic mechanism remains unclear. Furthermore, long-term prognosis is not clear since too few controlled longitudinal studies had been reported. Further prospective clinical trials are needed to define risk factors, to identify different subgroups of patients, and to lead to an effective therapy.

Adolescent↗

PubMedDate not supplied

[Long-term results of ambulatory antimycobacterial therapy. Studies of 556 cases].

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Ambulatory Care↗

PubMedDate not supplied

Notes on rehabilitation in vertebral-medullar cervical pathology.

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Humans↗

PubMedDate not supplied

Correlation between neuroradiological and electrophysiological investigations in multiple sclerosis with features of a cerebral tumour.

Multiple sclerosis presenting at onset with clinical signs and CT picture suggesting a cerebral neoplasm or a slowly evolving stroke, is uncommon. We report one patient in whom cerebral tumour was suspected not only clinically but also from CT features. M.R.I., demonstrating multifocal, high intensity, unsuspected periventricular and white-matter lesions, permitted to diagnose what seemed an intracranial left parietal neoplasm as an acute plaque of demyelination. In fact, in the follow-up, this large low-intensity left parietal area acquired structural and volumetrical homogeneity compared to all other present hyperintense lesions. Instead multimodal EPs, though disclosing subclinical dysfunction in the early stage of the disease, did not correlate with changes in neurological examination to follow-up. So they, unlike the M.R.I., seem of no particular usefulness to serially monitor the clinical modification of MS.

Adult↗

PubMedDate not supplied

Multimodality evoked potentials in sporadic amyotrophic lateral sclerosis: a statistical approach.

The involvement of sensory pathways in patients suffering from amyotrophic lateral sclerosis (ALS) is well reported in histopathological studies. Several laboratories have also used evoked potentials to evidentiate subtle dysfunctions of sensory systems in such patients. However, conflicting results have been presented in studies using evoked potentials. In the present experiment we have evaluated multimodality evoked potentials in subjects with sure diagnosis of sporadic ALS, by means of the Bonferroni multiple comparisons procedure. Our principal findings are: a) no statistical difference between patients and controls in BAEP and VEP recordings; b) a reduction of N13 amplitude and a prolonged P22 latency in SEP recordings. Due to the sources of N13 and P22, these latter alterations, however, do not implicate the involvement of somatosensory pathway. In conclusion, the current investigation does not provide an electrophysiological support for the involvement of sensory systems in the sporadic ALS.

Aged↗