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Biomedical subjects

V P Voĭtenko

Publications and source records attributed to V P Voĭtenko.

At least 19 recordsLinked to original sources
PubMed1990

[Hereditary effects on the rate of aging in humans].

Twin samples of various ages (154 pairs) were studied in transverse section and under longitudinal observation to assess the quantitative correlation of genetic and environmental influences on the age changes of 320 characters specifying different functional systems of the human organism: nervous, cardiovascular, respiratory, immune, endocrine, locomotor, metabolic, somatic, and mental. An evidence was obtained for a decrease in relative role of inheritance and increase in environmental (both systemic and scholastic) influences on the age-related changes in various organs and body systems of humans in aging. Therefore, the rates of aging and health status in humans may be controlled to some extent by exerting selective influences on the corresponding environmental factors.

Adult↗
PubMed1984

[Age, sex and ischemic heart disease mortality (factor model)].

A mathematical model of age mortality due to coronary heart disease among populations of the 24 European countries was made on the basis of the principal components method. It was shown that age and sex differences of mortality can be described by means of three different factors which are statistically independent on each other. Possible pathogenetic mechanisms underlying the formation of the three factors are discussed.

Adult↗
PubMed1984

[Phenogenetics of human dermatoglyphics (a factorial model)].

The factor analysis was made of the intrapair differences of the quantitative characteristics of the finger dermatoglyphics in mono- and dizygotic twins. The mechanisms determining "laterality" and "locality" of separate factors are discussed. The developmental model is proposed that suggests existence of several embryonic fields and subsequent incorporation of the genes to control the formation of finger prints.

Dermatoglyphics↗
PubMed1984

[Balanced hereditary polymorphism and the mortality from cardiovascular diseases in the populations of 17 countries of Europe. I. A correlation analysis].

The correlation analysis of ratios between six polymorphic genetic systems (ABO, MNSs, Rh, Hp, Gm, HLA) and mortality from ishemic heart disease, brain vascular lesions, and hypertensive disease in 17 European populations has been made. A statistically significant correlation has been established between the populational frequency of most of the 50 phenotypes and genes under study, and mortality. The qualitative structure of correlations and their quantitative expression depend on the cause of death, age and sex. The possible mechanisms of relationship between the genetic populational differences and mortality from cardiovascular diseases are discussed.

Adult↗
PubMed1984

[Balanced hereditary polymorphism and the mortality from cardiovascular diseases in the populations of 17 countries of Europe. II. A component analysis].

Based on the factor analysis (the method of principal components with a varimax rotation of axes), a study was performed on the component structure of interpopulational variations in frequencies of the 50 phenotypes and genes of six polymorphic human systems (ABO, MNSs, Rh, Hp, Gm, HLA). The genetic differences of populations have been found to be related to a small number of independent factors; 7 principal components have extracted 79% of dispersion from the primary data. Five of these components are coupled with mortality from the cardiovascular diseases. The component structure of mortality has specificity in relation to localization of pathological process, age and sex.

Adult↗
PubMed1981

[Polygenic threshold model and the phenogenetic aspects of human fingerprints].

Based on the existence of the two genetic complexes determining finger prints (SU - spiral and SR - despiral), the two-compartment multithreshold polygenic model for systematization of finger prints has been proposed. It was found that the radial loop is genotypically not identical to the ulnar loop, as it was thought before, but differs very much from the latter by its print. The relative height of thresholds for each of 10 fingers has been measured. The two embryonal gradients have been established: one with a positive, and the other with a negative correlation between the threshold heights.

Dermatoglyphics↗
PubMed1979

[Inheritance of human fingerprints].

Polygenic threshold model of finger dermatoglyphics inheritance is worked out on the basis of family and population data. According to the model, ulnar loops are subthreshold patterns, which transforms into whorl or arch under the control of SU and SR gene complexes. Epistasis-hypostasis interactions take place between genes of SU and SR complexes. Classification of phenotypes for finger dermatoglyphics is offered and the frequency of these phenotypes in three populational samples of Kiev is studied.

Dermatoglyphics↗
PubMed1975

[The origin of Barr-positive and Barr-negative dyshormonal tumors].

It has been found that females with dyshormonal tumors can be divided into two groups as to the incidence of sex chromatin in buccal mucosa. An existance of two groups differentiated by the sex chromatin incidence was also supported by the data obtained during examination of apparently healthy females of child-bearing age. The relationship has been established between the incidence of sex chromatin and certain features of the reproductive function. It may be assumed that the female population consists of two subgroups differentiated by a constitutional type of hormonal balance. Some evidences on population heterogeneity as concerns the factors determining the incidence of sex chromatin were obtained in studies of the latter conducted in males. We may suggest, therefore, the relationship between the two variants of dyshormonal tumors and two constitutional types of ageing.

Adolescent↗
PubMed1975

[Blood groups ABO, MN and Rh in diseases of the cardiovascular system].

Studies of theincidence of ABO, MN and Rh blood groups were carried out in 896 patients aged 40-89 with cardiovascular diseases and in 523 healthy people of the same age. High occurence of cardiovascular diseases was observed in patients having A and MM blood groups. The coefficient of relative morbidity A : 0 and MM:(NN +MN) depends on the age, the degree and the prevailing localization of the pathological process.

ABO Blood-Group System↗