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Biomedical subjects

V P Prasher

Publications and source records attributed to V P Prasher.

At least 37 records · Page 2Linked to original sources
PubMed1995

Epilepsy and associated effects on adaptive behaviour in adults with Down syndrome.

A total of 201 adults with Down syndrome were investigated, of whom 32 (15.9%) had epilepsy. A bimodal age distribution for seizure onset in childhood and later in middle-age was found. Good seizure control was associated with early onset epilepsy. Down syndrome adults with epilepsy scored significantly higher overall on the adaptive behaviour profile but did not have significantly greater maladaptive behaviours.

Activities of Daily Living↗
PubMed1995

Behavioural disturbance in people with Down's syndrome and dementia.

Behavioural disturbance associated with dementia in people with Down's syndrome has not been fully researched. This study investigated such problems in demented Down's syndrome subjects and nondemented Down's syndrome controls. Changes in mood, difficulty with communication, gait deterioration, loss of self-care skills, sleep disturbance, day-time wandering and urinary incontinence were found to be associated with dementia. Problems giving the greatest cause for concern to carers were restlessness, loss of communication skills, urinary incontinence and wandering. Care provision specifically focused on management of behavioural disturbance in individuals who develop dementia is recommended.

Activities of Daily Living↗
PubMed1995

Overweight and obesity amongst Down's syndrome adults.

Two hundred and one individuals with Down's syndrome were assessed for evidence of overweight and obesity. Thirty-one per cent of males and 22% of females were overweight, while 48% males and 47% females were obese. Overweight and obesity was significantly associated with living in the family home compared to supervised community units or in hospital. No association with the degree of learning disability was found.

Adolescent↗
PubMed1995

Podiatric disorders among children with Down syndrome and learning disability.

This study investigated podiatric pathology in seven- to 14-year-old children with Down syndrome (DS) and non-Down syndrome learning-disabled and non-learning-disabled age-matched controls. Several conditions, including pes planus, fissures, split toenails, increased plantar flexed first ray and a wide hallucal cleft were found to be more common in the DS group. Pes cavus and foot rigidity were more common in the non-DS learning-disabled group. In all groups the majority of children wore laced shoes, which were most ill-fitting among children with a learning disability. Approximately one-third in each group had abnormal foot-pressure prints. Greater care and professional awareness of podiatric pathology in children with learning disability is recommended.

Adolescent↗
PubMed1995

Partial trisomy 22 (q11.2-q13.1) as a result of duplication and pericentric inversion.

A case of a 27 year old male with a duplication of part of the long arm of chromosome 22 (22q11.2-q13.1) together with a pericentric inversion of the same chromosome is reported. Particular phenotypic features of note include absence of speech, persistent self-injury, lack of daily living skills, colobomata, and very poor vision. Similarities between this case and other case reports of duplications of the long arm of chromosome 22 are discussed.

Abnormalities, Multiple↗
PubMed1995

Differences in attitudes among medical students towards psychiatry in one English university.

Responses of 146 medical students in the final academic year on the Attitudes Towards Psychiatry Questionnaire were obtained before and after the clerkship in psychiatry. While there were no significant differences between the 57 men and 89 women, students' image of psychiatrists did not change but several initially held attitudes about psychiatric practice and training improved following the clerkship.

Adult↗
PubMed1993

Seizures associated with fluoxetine therapy.

Fluoxetine is a relatively new antidepressant, reported to have minimal side-effects. Seizures associated with fluoxetine therapy are uncommon. The five cases reported so far are reviewed. A case of fluoxetine induced seizures, in a person with Down syndrome, is described.

Adult↗
PubMed1993

Deletion of chromosome 2 (p11-p13): case report and review.

The case of a young man with del(2) (p11.2p13) is reported. Accounts of previous cases of deletion of the short arm of chromosome 2 are reviewed. Common features include mental retardation, proportional short stature and weight, dysmorphic facial features (a prominent nose, abnormal ears), and abnormal hands. Growth and developmental delay are present during the postnatal period.

Abnormalities, Multiple↗
PubMed1993

Worsening of pica as a symptom of depressive illness in a person with severe mental handicap.

The case of a person with severe mental handicap whose pica became uncontrollable during episodes of depressive illness is described. Treatment of the depression with lofepramine markedly reduced the pica, and withdrawal of lofepramine led to recurrence. It is suggested that biological symptoms of depression should be monitored in people with severe mental handicap who show significant episodic worsening of long-standing repetitive behaviour.

Depressive Disorder↗