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Biomedical subjects

V P Masenko

Publications and source records attributed to V P Masenko.

At least 91 records · Page 5Linked to original sources
PubMed1988

[Correlation of the total activity of blood plasma renin with levels of active and inactive renin, angiotensinogen and angiotensin II under different functional loads in patients with hypertension].

Components of the renin-angiotensin system (plasma renin activity, total and inactive renin, angiotensinogen and angiotensin II) were examined in 90 patients with labile and stable essential hypertension before and after functional and pharmacologic tests. New data have been obtained on intrasystemic regulatory mechanisms of the pressor renin-angiotensin systems. Different patterns of plasma active and inactive renin variations in response to salt loading are demonstrated in patients with different "renin" variants of essential hypertension. Angiotensin II is shown to have a stimulating effect on angiotensinogen synthesis.

Adult↗
PubMed1988

[The renin-angiotensin-aldosterone system and antidiuretic hormone secretion during plasmapheresis in patients with high arterial hypertension refractory to drug therapy].

Plasmapheresis (PP) was used in 28 patients with medication-resistant high arterial hypertension (AH). PP-induced changes in plasma renin activity and blood aldosterone, angiotensin II and antidiuretic hormone levels of patients with high AH are shown to be a compensatory-adaptive response, maintaining homeostasis. PP sessions (27 ml/kg body weight at a rate of 0.22 ml/kg/min, at the maximum) do not produce renin-angiotensin-aldosterone activation. Long-term hypotensive effect of PP in cases of high AH might be related to a gradual decrease in blood angiotensin II and systemic aldosterone synthesis. It is suggested that the hypotensive effect of PP may be due to an intricate interaction of effects, with humoral, receptor and circulatory re-adjustments of arterial BP control being the most prominent among those.

Adult↗
PubMed1987

[Changes in arterial pressure and concentration of several hormones in the blood effected by hemosorption in patients with arterial hypertension caused by parenchymatous diseases of the kidneys].

The authors present the indices of blood pressure (BP), plasma renin activity, the concentration of aldosterone, cortisol, adrenocorticotropic and antidiuretic hormones in 56 patients with arterial hypertension resulting from kidney parenchymatous diseases before hemosorption and at varying time after it. A decrease in the patients' BP is shown to occur in parallel with the redistribution of the blood levels of the above hormones. Possible mechanisms of BP reduction are discussed.

Adolescent↗
PubMed1987

[Unstable stenocardia: indicators of platelet activity and the effect of verapamil].

Beta-thromboglobin (BTG) and 4 platelet factor (4PF) blood concentration reflecting platelet functional state were determined by radioimmunoassay in 17 patients with unstable angina pectoris, in 18 patients with severe stable angina pectoris (IV functional class) and in 6 healthy subjects. Patients with unstable angina pectoris exhibited signs of platelet activation, i.e significant increase in blood BTG and 4PF concentration, which made qualitative difference from the patients with severe but stable form of the disease. The study of platelet activity at the peak of pain attack has demonstrated further increase in BTG and 4PF concentration in 6 patients having high initial characteristics. In 12 patients with unstable angina pectoris verapamil effect on the platelet functional activity was studied, they exhibited a decrease in BTG and 4PF concentration by intravenous injections as well as by long-term oral administration.

Adult↗
PubMed1987

[Growth hormone and prolactin levels of the blood in men with a history of myocardial infarct during rehabilitation].

The paper is concerned with a dynamic study of the level of the growth hormone (STH) and prolactin in the blood of male patients at different time of their rehabilitation after myocardial infarction (MI). STH concentration starting from the first determination (the 17th day) up to the end of the investigation (in 6 mos.) was below the level of the hormone in healthy males; with an increase in the time-period after MI acute phase the STH level was on a decrease. The time course of change of prolactin secretion was more complicated. The first points of determination (the 17th and 30th days) showed a significant increase in prolactin, then its level dropped not only below indices of the initial points of determination but also significantly below the hormone level in the control group.

Adult↗
PubMed1987

[Effect of the ulcerogenic agent cysteamine on the content of glutathione and glutathione-dependent enzymes in the mucous membrane of the gastroduodenal region in the rat].

A comparative study of reduced and oxidized glutathione forms and the activity of glutathione-dependent enzymes (glutathione peroxidase, glutathione-S-transferase, and glutathione reductase) has been performed in the rat mucous membranes of different gastroduodenal areas 24 hours after the injection of cysteamine--a specific ulcerogenic agent. It has been shown that cysteamine causes a decrease in the concentration of reduced and an increase in the concentration of oxidized glutathione forms in all gastroduodenal areas. The fall in reduced glutathione form concentration is the greatest in the duodenal mucosa. A considerable decrease in glutathione-dependent enzyme activity, especially glutathione-S-transferase, was observed in duodenal mucosa. It is concluded that glutathione and glutathione-dependent enzyme system may be directly related to pathogenetic mechanisms of gastroduodenal ulcer formation.

Animals↗
PubMed1986

[Effect of anti-arrhythmia preparations on thrombocytic and vascular hemostasis].

Platelet aggregation, prostacyclin and thromboxane were studied in 35 individuals: 20 coronary patients with angina of effort and 15 high-risk patients before and after treatment with lidocaine and pyromecaine. Oral administration of lidocaine and pyromecaine pills considerably depresses platelet aggregation and even causes platelet disaggregation. However, lidocaine disaggregating effect is greater than that of pyromecaine. Both agents affect vascular hemostasis by reducing thrombaxane and raising prostacyclin levels. Hence, the anti-aggregant effect of anti-arrhythmic proocaines may be attributed to changes in vascular hemostasis. The results obtained are expanding the range of indications for the use of these drugs.

Adult↗
PubMed1985

[Use of captopril (capoten) in arterial hypertension].

Capoten (captopril) treatment was conducted in 39 patients with essential hypertension of stage IIA-IIB and in 4 patients with idiopathic hyperplasia of the adrenals. In 35 patients the hypotensive effect was evaluated following a single administration of captopril in a dose of 12.5, 25 and 50 mg. Twelve patients were treated with this drug alone while in 23 patients it was combined with saluretics. Captopril monotherapy elicited a good and moderate hypotensive effect in 70% of patients with a high and stable hypertension. Both mono- and combined therapy was associated with a decrease in adrenaline and noradrenaline excretion and an increase in uterine kallikrein excretion. The examination of the regional circulation revealed a significant reduction in the resistance and tonus of the arterioles and an enhancement of the blood flow in the forearm as well as an increase in venous tensility. When captopril was combined with diuretics these changes were less marked.

Adult↗
PubMed1985

[Clinical and hemodynamic effectiveness of isolated ultrafiltration in the treatment of patients with severe cardiac insufficiency].

A study was made of the clinical and hemodynamic efficacy of a session or a course of isolated ultrafiltration (IUF) and a relationship of changes of the central and peripheral hemodynamics with the activity of the renin-aldosterone system in patients with severe cardiac insufficiency. Two groups of patients were singled out differing in their hemodynamic and hormonal response to the first IUF session that might be due to a different level of adaptation mechanisms acting in the interference in disturbed homeostasis.

Adult↗