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Biomedical subjects

V P Kharchenko

Publications and source records attributed to V P Kharchenko.

At least 19 recordsLinked to original sources
PubMed1995

[Multiple primary malignant neoplasms and survival of patients with stage-I lung cancer].

The study group included 2161 patients operated on in 1968-1990. Tumors stage I were morphologically confirmed in 910 cases (T1S-3, T1-375 and T2-532). 827 patients survived 5 years (90.9%); 551 patients-10 years (60.3%). Primary multiple neoplasms (PMN) of different localization were detected in 96 (10.6%) patients with stage I tumors. Thirteen patients (13.5%) died of progression of a second tumor; 17 (17%)-of other causes. Average 5-year survival was 65%, 10 years-53%. These indices in 96 patients with PMNs were 73 and 53%, respectively. Relative risk of PMN in lung cancer was found to be in direct correlation with survival time and to depend, to a large degree, on tumor extension. When PMNs are detected early and treated radically, new primary tumors emergence does not significantly in lung cancer stage I. Preliminary results showed chemotherapy (neoadjuvant one included) to lower the risk of PMN in lung cancer stage I. The most plausible causes of enhanced survival of patients with PMNs are discussed.

Female↗
PubMed1994

[Reconstructive surgeries of lung cancer].

The proportion of reconstructive operations on the bronchi and tracheal bifurcation at the current level of the development of surgery for lung carcinoma is sufficiently high. Among 2,075 lung resections performed at our clinic reconstructive operations were carried out in 31.6% of cases. The success of reconstructive surgery in lung carcinoma is determined to a great measure by the correct choice of the indications for this type of surgical treatment, preoperative management, the level of surgical techniques and anesthesiological service, and postoperative management of the patients. Five-year survival depending on the stage and method of treatment after lob-, bilobectomy with resection and plastics of the bronchi and tracheal bifurcation was 28.3-67.4%, and after pneumonectomy with resection of the bifurcation of the trachea it ranger from 16.2 to 43.3%.

Humans↗
PubMed1992

[The preoperative morphological diagnosis of hepatobiliary and pancreatoduodenal cancer].

Morphological investigations at the preoperative stage were performed in 94 patients. The morphological diagnosis was made on the basis of findings of duodenal biopsies, cytological investigations of the bile and aspirate from the Vater's papilla ampulla, endocholedochal and percutaneous biopsies with the express cytological monitoring. Recommendations are given on the programs of preoperative morphological diagnosis of carcinoma of Vater's papilla.

Adult↗
PubMed1991

[Combined digital subtraction angiography and cholangiography in assessing the spread of the tumor process in pancreatobiliary cancer].

The paper is concerned with comparative assessment of the efficacy of digital subtraction angiography and routine angiography in assessing tumor spreading in pancreatobiliary cancer. A combined method of digital subtraction angiography and cholangiography was developed and performed in 41 patients with pancreatobiliary cancer permitting maximum information on the topical location and spreading of a tumor process. The clinical importance of the obtained results permitted recommending simultaneous digital subtraction angiography and cholangiography in patients with hepatobiliary cancer.

Ampulla of Vater↗
PubMed1991

[Radiation pathomorphosis in single and intensive-concentrated preoperative irradiation of colon cancer].

Single (7.5 Gy) or intensive-concentrated (20 Gy at 5 daily fractions of 4 Gy each) preoperative irradiation was given to 42 colon cancer patients. Operation was performed not later than 24 h after single irradiation and 1-3 days after intensive-concentrated irradiation. Radiation pathomorphosis was studied on histological and electro-microscopic examination of biopsy specimens. Dystrophic changes of tumor cells were noted following the use of both methods, though more noticeable ones were observed after intensive-concentrated irradiation. Obstruction of the microcirculatory bed of a tumor appeared to be a characteristic sign of a tumor stroma response both in single and fractionated irradiation. It was assumed that the latter together with direct radiation damage of tumor cells could be very important to the prevention of implantation recurrences and metastases.

Biopsy↗
PubMed1991

[Surgical treatment of lung cancer after myocardial infarct].

The work deals with 70 patients with lung carcinoma and ischemic heart disease and with a history of myocardial infarction. The minimal period between the infarction and the operation was 4 months. The oldest patient was 72 years of age. Patients with I (44%) and III (36%) stages of the disease prevailed. Pneumonectomy (15), lobe-bilobectomy (46), economical resection (7), and explorative thoracotomy (2) were conducted. Reconstructive-plastic organ-preserving and economical resections of the lung widen the indications for surgical treatment of patients with a history of myocardial infarction. Preoperative and postoperative management of patients is recommended. It is preferable to operate on patients with lung carcinoma and a history of myocardial infarction no earlier than 6 months after the infarction. Five-year survival among patients who underwent radical operation was 29.2%, among those treated by lobe-bilobectomy and economical resection, 42.5%, and after pneumonectomy, 18.2%.

Adult↗
PubMed1990

[The cytological study of the bile in the diagnosis of pancreatobiliary cancer].

Treatment of 46 patients with mechanical jaundice of the inflammatory-calculous and tumorous nature is described. In 26 patients with external drainage of the bile ducts the cytological investigation of 3-5 morning portions of bile was performed. The lavage fluid was studied in 4 cases. On the basis of the findings of these cytological investigations carcinoma was diagnosed in 20 of 24 patients with tumorous processes (83.3%). A comparison of data obtained by histological and cytological investigations in 19 patients operated upon was made.

Bile↗
PubMed1990

[The combined treatment of lung cancer with one-time large-fraction preoperative irradiation].

A procedure of preoperative large single dose (7.5 Gy) irradiation of lung cancer was developed. Irradiation field included regional lymph node-bearing areas. Treatment was employed in 93 lung cancer patients. Postoperative complication and lethality rates were 14 and 2.2%, respectively. Patients presenting with metastases in the regional lymph nodes were postoperatively irradiated to the lung hilus and mediastinum (30 Gy in 10 fractions). The treatment was well tolerated. Eighty-eight patients were followed, of whom 43.3% survived 3 years. The above modality assured ablastics of surgery and allowed to minimize duration of preoperative radiotherapy.

Adenocarcinoma↗