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Biomedical subjects

V P Gurbanov

Publications and source records attributed to V P Gurbanov.

At least 19 recordsLinked to original sources

Red cell enzyme types in rheumatic diseases.

We studied the frequencies of red cell enzyme types, AcP, PGM1 and EsD in 213 patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), rheumatic heart disease (RHD), scleroderma (Scl) and psoriatic arthropathy (PsA). The differences in frequency of AcP phenotypes between RA, Scl, and PsA and the Moscow population were significant. In PsA the PGM1 phenotype 1-1 frequency was significantly decreased, while the phenotype 2-1 frequency was significantly increased.

Acid Phosphatase↗

[2 levels of association possibilities for acrocentric chromosomes in 2 chromosomal associations of human lymphocytes].

Association potentialities of acrocentric chromosomes were evaluated from the frequencies of associations consisting of two homologues. The evidence obtained enabled one to calculate the frequencies of associations consisting of two nonhomologous and mixed acrocentric chromosomes. Such frequencies turned out to occur 4-fold less than empiric frequencies of the respective associations. This is possible with 2-fold increase in the association potentialities of each acrocentric chromosome entering the association of two nonhomologous and mixed chromosomes. A correlation performed according to Pirson's criterion revealed a good agreement of empiric and theoretic frequencies calculated with due regard 2-fold magnification of the association potentialities. This finding does not reject a hypothesis of 2-fold magnification of the association potentialities in acrocentric chromosomes entering the association consisting of 2 non-homologous and mixed chromosomes.

Chromosomes, Human, 13-15↗

[Comparison of two means of identifying satellite associations in man].

Two methods of identifying satellite associations were compared in ten normal donors. Conventional Giemsa stain proved to identify by 31% less of 3-chromosomal associations, by 50% less of 4- and 5-, and by 66.6% less of 6-chromosomal associations than in staining with ammoniacal silver, whereas the number of 2-chromosomal associations was by 10% greater, this conditioning the prevalence of small associations. Silver staining used to expose intersatellite associations revealed acrocentric chromosomes mutually oriented, placed close to one another, but without any intersatellite connection. In Giemsa-stained preparations these are considered to be associating, which increases the number of multiple groups. Both errors of the conventional Giemsa method cannot be corrected. Identification of associations according to intersatellite connections is free of these errors after silver staining.

Chromosome Aberrations↗

[Intersatellite connections of the human acrocentric chromosomes that participate in associations].

Intersatellite connections between acrocentric chromosomes in associations were revealed by the method of thermal ammoniacal silver staining. The associations were allotted to the corresponding groups on the basis of the number of chromosomes. Distribution of D- and G-chromosomes in associations was studied on the basis of 714 associations from 500 metaphase plates of 10 normal individuals. The hypotheses of hypergeometric, binomial, Poisson, uniform and exponential distribution laws of D- and G-chromosomes in associations were rejected. The hypothesis of normal distribution was not rejected. The principal characteristics of normal distribution law were found. The distribution law of the number of D- and G-chromosomes in associations was written analytically; the central moments and other characteristics were presented.

Adult↗

[Quantitative distribution of satellite associations differing according to the number of chromosomes in human lymphocytes].

Statistical analysis of quantitative distribution of associations formed by 2, 3, 4, 5 and 6 acrocentrics (associations with a different numerical composition) revealed a good concordance of the empirical frequencies with the theretical ones calculated by the exponential distribution law with the basis of two. A good concordance in all the donors studied pointed to the strict regularity of the quantitative distribution of associations with a different number of acrocentrics and their special significance in human lymphocytes.

Chromosomes, Human↗

[Sequential staining for G- and C-banding of chromosomes in the analysis of the morphology of the short arms of human acrocentric chromosomes].

Sequential staining for G- and C-banding of acrocentric chromosomes of 8 persons showed that the large heterochromatin region occurred more frequently in chromosome 15 than in chromosomes 13 and 14, and in chromosome 22 more frequently than in chromosome 21. There proved to be no correlation between the size of the heterochromatic region and the short arm of the acrocentric chromosomes. The frequency of occurrence of the satellites in the 8 persons was approximately the same for all the acricentric pairs. The C-banded satellite region of the homologous chromosomes is often heteromorphic.

Chromosome Aberrations↗