When introduced repeatedly prior to the onset of pregnancy chlorpromazine in a dose of 16 mg/kg limits the progeny of albino mice. An important factor responsible for the reduction in the number of young mice in the litter is inhibition of oogenesis. A single injection of the same dose of chlorpromazine made at the end of gestation (18th day) against the background of its preliminary administration before the onset of pregnancy results in an interruption of the latter, or in a gravely disturbed post-natal development of some of the offsprings. The disturbances find their expression in a delayed growth and motor activity, incoordination of motions and are accompanied by changes in the tegument, diarrhea (form the moment of changing over to a mixed alimentation), in underdevelopment of the organs and of histological structures that are part of them.

Abnormalities, Drug-Induced↗

PubMedDate not supplied

Comparative cytochemical study of sympathetic neurons in thoracic portion of lateral sympathetic trunk in vertebrates.

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Animals↗

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[Quantitative criteria of a rhinocytogram of healthy subjects].

Presents qualitative and quantitative characteristics of normal rhinocytograms obtained by cytologic investigations of smears impressions from the surface of the anterior portion of the inferior turbinate bone and processing of the results by variation statistics methods. Actually only solitary scales and superficial cells of multilayer squamous epithelium and small groups of ciliary epithelium cells may be reliably present in a normal rhinocytogram of man.

Cytological Techniques↗