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Biomedical subjects

V P Drobysheva

Publications and source records attributed to V P Drobysheva.

14 recordsLinked to original sources
PubMed1991

[The overdiagnosis of bacterial endocarditis].

The diagnosis of bacterial endocarditis (BE) is analyzed in 255 patients. After examination, the diagnosis of BE was verified but in 92 patients (36.1%). Of these, BE was overdiagnosed in 163 patients (63.9%). The main causes of the overdiagnosis were body temperature rise in 134 patients (52.6%), heart murmur in 163 patients (63.9%), and positive hemoculture in 57 patients (22.3%). Three cases of BE overdiagnosis are provided. Exaggeration of the specificity of body temperature rise in patients with heart murmur often leads to BE overdiagnosis. Mitral valve prolapse is one of the predisposing BE factors. At the same time it is a cause of overdiagnosis of BE in patients with fever, BE overdiagnosis often results in unbased long-term antibacterial therapy, while other causes of the symptoms are not considered. Ineffectiveness of antibacterial treatment (no clinical improvement, continuous or recurrent fever) points to the necessity of further diagnostic search.

Adolescent↗
PubMed1991

[Kidney involvement in infectious endocarditis (hematuria)].

As many as 113 patients suffering from infectious endocarditis (IE) were placed under observation. Renal damage was discovered in 28 patients (24.7%). Hematuria was the common laboratory sign of renal damage. 15% of patients showed microhematuria, 9.7 had macrohematuria. In 15% of patients with IE, hematuria was due to diffuse glomerulonephritis, in 5.3% to renal infarction, and in 4.4% to focal glomerulonephritis. In 3.5% of patients, the nephrotic syndrome developed at the disease onset, it was attended by hematuria and was thus a cause of erroneous diagnoses. The appearance of hematuria at the IE onset, attesting to involvement of the kidneys into the pathological process, complicates the diagnosis and early treatment institution. Detection of the hematuric syndrome in patients with a verified diagnosis of IE requires specification of the character of renal damage. The latter one contributes to a graver and prognostically unfavourable course of IE. In 2 out of 8 patients with associated IE and renal damage, the death was caused by progressive chronic renal failure. Postmortem examination confirmed mesangioproliferative glomerulonephritis in all the subjects; in 4, it was coupled with renal infarction. 14.1% of the patients manifested complete and 3.5% partial disappearance of hematuria under the influence of adequate antibacterial therapy of IE.

Adult↗
PubMed1988

[Bacterial endocarditis: its current course and diagnosis].

Investigations have shown that the etiology of bacterial endocarditis (BE) has notably changed, with the prevalence of highly virulent agents which alter a course of disease and often determine a lethal prognosis. A positive NBT-test permits more rapid and accurate detection of systemic bacterial infection than investigations of hemoculture, indicates a high phagocytic activity of neutrophils at the active stage of BE irrespective of a course of disease and permits earlier use of antibacterial therapy. A high activity of antibodies to teichoic acids indicated much earlier and more accurately Staphylococcus aureus as an etiological agent than investigations of hemoculture. It permits early etiotropic chemotherapy when it is more effective. Investigations of antibodies to teichoic acids over time makes it possible to assess the effectiveness of therapy of BE as at the inactive stage of disease the test becomes negative. Enzyme immunoassay of antibodies to native and denatured DNA reveals an active autoimmune process in BE patients, ongoing alterative processes--all of them can be used for characterization of a course and prognosis of disease. Etiotropic therapy alters the nature of a BE course, increasing the number of patients with a chronic course of disease in whom remissions are alternated by recurrences.

Antibodies, Bacterial↗
PubMedDate not supplied

[Ciprofloxacin in the treatment of staphylococcal endocarditis].

Ciprofloxacin was used in treatment of 5 patients with infectious endocarditis and bacterial vegetations on the values by the findings of the echocardiography. The hemocultures produced the growth of Staphylococcus epidermidis and S. aureus in 3 and 2 patients respectively. The degree of endocarditis was high in 3 patients and intermediate in 2 patients. The drug was administered intravenously in a dose of 200 mg 2 times a day for 4 weeks. The efficacy of the treatment was estimated by following-up the disease time course: the patients were examined prior to the treatment, every week during the treatment and after the treatment completion. The complex clinico-laboratory investigations showed that ciprofloxacin (Ciprinol, KRKA, Slavonia) is a highly efficient chemotherapeutic drug of the group of fluoroquinolones for the treatment of infectious (staphylococcal) endocarditis due to the sensitive microbes. The intravenous drug is useful in treatment of severe forms of infectious endocarditis. The drug is not toxic and well tolerated by the patients after its intravenous administration.

Adult↗