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Biomedical subjects

V P Babmindra

Publications and source records attributed to V P Babmindra.

At least 19 recordsLinked to original sources
PubMed1998

[Structural basis for the regulation of the neuronal sensitivity].

Using light and electron microscopy structural bases for intracellular, extracellular and integrative regulation of synaptic efficiency and neuron sensitivity were established in rat sensomotor cortex. Intracellular regulation is realized basically through modulation of postsynaptic components of the synapse, while extracellular one is provided by synaptic endings of "recurrent" axons on GABA-ergic relay and interneurons. Integrative regulation is realized by means of concentration of similar axonal terminals in restricted cortical area and arrangement of "neuromediatory" pool.

Animals↗
PubMed1996

[The neuronal theory and new concepts of the structure of the nervous system].

An analysis of neuron theory modern state was carried out on the base of data from literature and available material. The idea of anatomic, functional and biochemical polarity self-dependence of a neuron and its histochemical polarity have changed significantly. It is said to be confirmed that neuron does not work on its own, its trophics is impossible without glia and one neuron may contain not one but several mediators combined with modulators and regulatory neuropeptides. Postulates on the nervous system module organization seems to be the most well-grounded.

Animals↗
PubMed1996

[The identification of synapses in the cerebral cortex].

The correlation between structure and function of synapses is discussed. Identification of 4 types of synapses has been made based on the authors' own evidence provided for the rat sensomotor cortex with the light and electron microscopy: 1--asymmetrical (excitatory, glutamate- or aspartatergic); 2--symmetrical (inhibitory, GABAergic); 3--symmetrical (disinhibitory, GABAergic); 4--symmetrical or asymmetrical (modulatory, monoaminergic). The ultrastructure of some synaptic categories may be equalized with their function. It makes possible to identify not only excitatory and inhibitory synapses, as considered before, but also disinhibitory and modulatory ones.

Animals↗
PubMed1988

[Structural bases of the plasticity of the nervous system].

The present state of morphological study of variability in the nervous elements under conditions of adaptive change under the influence of afferent effects, age changes during different periods of ontogenesis, under conditions of de- and regeneration of synapses have been considered. A question on correlation between structure and the function of synapses during the change has been analysed. The tasks of subsequent study of this problem have been outlined.

Adaptation, Physiological↗
PubMed1984

[Neurokinetic hypothesis of synaptic efficiency].

A hypothesis is advanced stating that the dendrite spine is a cilium-like process of the neuron's chemoreceptor membrane provided with sensitive and motor mechanisms. The axo-spinous contacts in the c.n.s. can be controlled by a post-synaptic element. The Ca2+ induces a contraction of the actine molecules contained in the spine base, increases the diameter of the latter and decreases resistance against spreading of the electrotonic potential towards the stem of the dendrite. This mechanism seems to take part in the processes of learning and memory.

Actins↗
PubMed1984

Interneurons of the cat sensorimotor cortex.

In this paper a review is given on the interneurons of the cerebral cortex, their subdivisions and neurophysiology. Special concern is given to short axon (local) interneurons and long-axon (association and callosal) stellate cells. Data obtained from simultaneous recordings of more than one neuron are also presented. However, further research is needed to demonstrate the essential role of the interneurons in information processing.

Animals↗
PubMed1984

[Structural organization of preganglionic sympathetic neurons].

Distribution of marked preganglionic neurons over spinal nuclei and segments was studied in cats with the aid of microinjections of the horse-radish peroxidase into the cranial cervical ganglion. The major part of these neurons were revealed in the main part of the intermediolateral nucleus. A somewhat lesser number of the cells were found in the funicular part of the nucleus. In the T1 segment they constituted about 90% of cells containing the peroxidase. Other neurons were localized in the paraependymal and intercalative nuclei. In longitudinal sections of the spinal cord, the preganglionic sympathetic neurons projecting their axons into the cranial cervical ganglion, form a rostro-caudal chain made of small ensembles of cells.

Animals↗
PubMed1982

[Associative and callosal stellate neurons in the parietal area of the cat cerebral cortex].

After horseradish peroxidase has been injected into the cat parietal area, in the ipsilateral visual and limbic cortical areas, as well as in the contralateral parietal area long axonal associative and callosal stellate neural cells are revealed. Their bodies are round or oval, 18-25 mcm in size. In the associative neurons--they are always labelled better than the callosal ones--radial arrangement with nearly an equal distance between each other is specific for the dendrites, while in the callosal neurons they are grouped polarly. The associative stellate cells are situated in the layer II and in the upper part of the layer III of the visual and limbic cortex at the side where the enzyme is injected, and the callosal ones--in the lower part of the layer III and in the layer IV of the homotypical portions of the contralateral parietal cortex area. The main difference between the neurons detected is a various length of the axon. In the cortico-cortical ipsilateral neurons the axons are nearly 3--4 times shorter than those in the commissural stellate cells. Hence, the neuronal category described is present not only in the projection cortical zones, as it has been stated previously, but in the associative areas, as well.

Animals↗
PubMed1980

[Associative connections of the parietal region of the cerebral cortex in cats].

The interneuronal connections of the parietal associative cortex were studied in cat using the methods of retrograde axonal transport of horseradish peroxidase (HRP) and terminal degeneration (Fink-Heimer). Data on laminar topography of the afferents within area 7, and the nature of axonal terminals from visual, auditory and somatic sensory fields of cortex were obtained. The places of concentration of associative neurons and their morphological characteristic are described.

Animals↗
PubMed1980

[Use of antero- and retrograde horseradish peroxidase transport to analyze interneuronal connections of the bat auditory system].

Tpe experiment were performed on the horsseshoe-nosed bats (Rhinolophus ferrumequinum). Horseradish peroxidase (HRP) 25% solution was administered into the central nucleus of the inferior tubercles of the corpora quadrigemina. After two days, in the contralateral similar nucleus a great number of labelled multipolar neurons was revealed. Terminal axonal branchings which get into the nucleus studied via the interquadrigeminal commissure were detected near these neurons. Antero- and retrograde axonal transport of exogenic HRP made it possible to ascertain bilateral connections existing between the left and right central nuclei of the inferior colliculi. A suggestion was made on a reciprocal character of the relations, since labelled efferent terminals constantly occurred near the labelled afferent neurons.

Animals↗
PubMed1979

[Morphofunctional interrelationships between the hippocampus and hypothalamus in rats].

Evoked reactions of the hypothalamic arcuate and medial preoptic nuclei neurons were recorded when the hippocampus was stimulated by single stimuli in anaesthetized rats. In the arcuate nucleus phasic responses and primary inhibition were found to be dominant and in the medial preoptic nucleus--both phasic and nonspecifical responses. After injection of the horseradish peroxidase into the stimulated hippocampal region stained cells were found in the nuclei of the mammillary complex, mediobasal hypothalamus and in the medial preoptic nucleus. Groups of stained neurons were observed in the periphery of ventro- and dorsomedial, lateral and mammillary nuclei of the hypothalamus. In all the studied structures, except the medial mammillary nucleus, reticular-like cells were found alongside with spindle-like and triangle neurons. The data obtained are discussed in connection with the problem of hypothalamo-hippocampal interaction.

Animals↗