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V P Alekseev

Publications and source records attributed to V P Alekseev.

16 recordsLinked to original sources
PubMed2001

[Epidemiology of ischemic heart disease and characteristics of atherosclerosis in male residents in Yakutsk].

AIM: To study trends in prevalence, risk factors (RF) and mortality of ischemic heart disease (IHD), contribution of RF to risk of death due to IHD and other cardiovascular diseases (CVD) among male population of Yakutsk; to determine characteristics of atherosclerosis among native male population and migrants. MATERIAL AND METHODS: A clinicopathological epidemiological trial covered male population of Yakutsk. It was performed by standard techniques within the scope of the cooperative program. RESULTS: The analysis of the trends for the last 10 years demonstrates a marked rise in the incidence rates of arterial hypertension (AH), overweight and hypercholesterolemia. CVD mortality reached 38.4% of overall mortality. Such factors as AH, smoking, IHD, ischemic ECG changes and overweight contribute much to the integral risk of CVD death. A comparative morphometric analysis of atherosclerosis development in 1965-1968 and 1985-1988 showed accelerated development of atherosclerosis both among native population and migrants in 1985-1988. There are population differences in development of atherosclerosis in males from native population and migrants. The effects of trace elements on formation of atherosclerosis components in the Far North were evaluated. CONCLUSION: Present-day epidemiological situation in relation to IHD and other CVD necessitates further monitoring of the situation, activation of primary and secondary IHD prevention among population of the Far North.

Acclimatization↗
PubMed1997

Viliuisk encephalomyelitis--review of the spectrum of pathological changes.

Viliuisk encephalomyelitis (VE) is an unique neurological disease occurring in the Iakut (Sakha) people of Siberia. Evolution of the disease follows one of three broad clinical forms: subacute, slowly progressive or chronic. Death occurs within 3 to 6 months in subacute cases and within 6 years in the slowly progressive cases. Chronic cases lack a subacute phase but show a slowly progressive dementia associated with bradykinesia, dysarthria and spastic paraparesis that stabilizes late in the disease process. In subacute and slowly progressive cases, focal necrotizing encephalomyelitis is seen at necropsy. Chronic cases show multifocal areas of lysis with a gliotic margin, predominantly within grey matter, lacking associated chronic inflammatory changes seen in the other forms of the disease. Epidemiological studies are consistent with a disease of low-grade communicability, but laboratory studies have so far failed to reveal an infectious organism. The spectrum of neuropathological changes are reviewed in this examination of 11 cases. Although the aetiology of VE remains obscure, further studies are warranted since it may represent a novel disease process.

Acute Disease↗
PubMed1995

[Changes in the course of atherosclerosis occurring over a 25-year period in the male population of 9 cities of the CIS and Baltic countries].

The trends in atherosclerosis presentation were followed up pathomorphologically in a two-stage epidemiological survey performed in 9 cities of CIC and Baltic states at 25-year interval. The investigations were conducted in accordance with WHO program. Stage 1 (1963-1968) covered 6121 cases, stage 2 (1985-1989) included 9201 cases. The material was collected on the condition of aortas and coronary arteries from 20-59-year-old males who were residents of the cities of Irkutsk, Yakutsk, Tallin, Tartu, Riga, Kharkov, Yalta, Ashkhabad, Bishkek. The 2-stage examinations gave evidence for growing severity of atherosclerosis. Risk factor analysis demonstrated an increase in the percentage of males with diabetes mellitus and arterial hypertension, in the percentage of overweight males and of those with atherosclerosis engaged in mental work. It is found that atherosclerosis undergoes changes within the life of one generation (for 20-25 years).

Adult↗
PubMed1991

[Structure of aortic lipid spots in two ethnic groups of the Yakutsk population].

Histometric study of aortic lipid spots (LS) in males of both ethnic groups who died of incidental causes at the age of 20-39 showed a decrease of the lipid-containing smooth muscle cells number (SMC), an increase of the foam cell (FC) number and extracellular lipids, retraction of the non-lipid zone surface in LS in proportion with their thickening. LS on the aorta with fibrous plaques in both Yakuts and Russians are characterized by the accumulation of FC, extracellular lipids and by their trend to the thickening as compared to LS in the aorta without fibrous plaques. Thick aortic LS in Russians with a predominant accumulation of FC in the superficial and intermediate layers are the most probable precursors of the atherosclerotic plaque.

Adult↗
PubMed1989

[Atherosclerosis of the aorta and coronary arteries in men living in Iakutia (an epidemiologic pathologo-anatomical study)].

A quantitative study was made of atherosclerosis in the aorta and coronary arteries in 3 groups of 20-59-year old male patients: (1) aborigines such as Yakuts, Chukchi, Evenks; (2) those born in the North (Russians born in Yakutia); and (3) new comers (120, 103, and 233 cases, respectively) after Sudan IV staining of the aortas and coronary arteries. The frequency and extent of fatty streaks, fibrous plaques, complicated lesions, and calcinosis were determined. The severity of atherosclerosis was found to be slightest in the aborigines; differences between those born in the North and new comers were small; yet coronary stenoses (greater than or equal to 50% of the lumen) were substantially more common in the former. Aortic intimal rhythmic structures were significantly more frequently detected in the aborigines than in those born in the North and new comers. The age-specific parameters for the abdominal aorta in the age groups of 20-59 years were 58.9, 37.0, and 39.8%, respectively.

Adult↗
PubMed1987

[Not Available].

Explore the source record for details and available documents.

Genetics↗
PubMedDate not supplied

High-sensitivity C-reactive protein, adiposity, and blood pressure in the Yakut of Siberia.

C-reactive protein (CRP), an acute-phase reactant and marker of inflammatory response, is known to be an important predictor of future cardiovascular mortality, independent of other risk factors. The purpose of this research was to investigate the association between CRP, adiposity, and blood pressure in the Yakut, an indigenous Siberian population undergoing rapid cultural change. We conducted a cross-sectional study of 265 healthy Yakut adults in six villages in rural northeastern Siberia. Plasma CRP was measured by high-sensitivity immunoturbidimetric assay. The median CRP value was 0.85 mg/l, with values for the 25th, 50th, and 75th percentiles of 0.30, 0.85, and 2.28 mg/l, respectively. CRP was positively associated with age (r = 0.19; P = 0.002), but not plasma lipids or smoking status. CRP was associated with measures of central adiposity and characteristics of the metabolic syndrome, particularly in women. We found significantly higher CRP across quintiles (Q) of waist circumference for women (difference = 0.7 mg/l; P = 0.035), but not men (difference = 0.36 mg/l; P = 0.515). CRP was significantly associated with systolic blood pressure in men (difference, Q1 vs. Q5 = 1.1 mg/l; P = 0.044) but not women (difference, Q1 vs. Q5 = 0.03 mg/l; P = 0.713) after adjusting for age, waist circumference, and smoking status. CRP in the Yakut was considerably lower than was reported for other populations. The low CRP levels may be explained in part by a low prevalence of abdominal obesity. Among the Yakut, the high physical-activity demands of a traditional herding lifeway likely play a role through high energy expenditure and maintenance of negative energy balance. Our findings underscore the need for further research on the metabolic activity of adipose tissue, blood pressure, and inflammatory activation in non-Western populations.

Adiposity↗
PubMedDate not supplied

[New information on the histopathology of Vilyui encephalomyelitis: possible role of copper deficiency].

The nature of a pathological process in the central nervous system in Vilyui encephalomyelitis defines it as a specific entity of demyelinative encephalomyelitis with a drastic prevalence of an alternative component. The bulk of the nerve parenchyma dies from circulatory incompetence due to blood vascular diseases, which are typical of the disease, as a peculiar angiopathy and progressive reduction in the microcirculatory bed. Homeostatic disorders in the myelinic membranes of central nervous fibers were found to be of value. The maintenance of homeostasis is implicated by adequate oligodendroglial function and copper metabolism. The inhabitants of the Republic of Sakha (Yakutia) are demonstrated to have oligodendroglial hypoplasia and exogenous and endogenous copper deficiency. This is suggested by low copper amounts in the natural environmental objects and in the hair of patients with chronic Vilyui encephalomyelitis.

Chronic Disease↗
PubMedDate not supplied

[New data on the epidemiology and morphology of Viliuisk encephalomyelitis].

Viliuisk encephalomyelitis (VEM) appears to be endemic disease, affecting native population in Yakutia (Yakut, Even, Evenk). The infectious nature of VEM is very likely, but not yet established with certainty. The mortality rate caused by VEM from 1950 to 1990 was 17.4 per 10000 of native population. The maximum morbidity can be seen in Viliui and Central zones of Yakutia. Women were affected one and a half times more than men. VEM is characterized by multiple micronecrotic foci with marked inflammatory reactions and gliosis in the brain tissue. The vascular component in VEM is manifested by vasculitis, plasmarhagies, obliteration of the capillary lumen with development of capillarofibrosis, progressive reduction of the microcirculatory bed, the deformation of walls in major vessels with atrophy of their muscular layer, in some cases--by hyaline thrombi. The data presented give no grounds to consider the vascular component as secondary, relating only to the brain atrophy.

Adolescent↗