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Biomedical subjects

V O Samoĭlov

Publications and source records attributed to V O Samoĭlov.

At least 19 recordsLinked to original sources
PubMed1991

[Role of cyclic nucleotides in carotid chemoreception].

The activation of the metabolic systems of rat carotid body under the influence of alkaloids and acids was studied by spectrofluorimetric technique. It has been demonstrated the growth of the cAMR levels being suggested to the role of messenger between chemical stimuli and the flows of glomus cells metabolism. Chemical substances of other types (such as acetylcholine, NaCl saccharose) don't provide any changes of cell respiration and concentration of cAMP in carotid cells. The data obtained provide the evidence of heterogeneity of glomus cella reception mechanisms of the qualitatively different chemical substances. It supports the hypothesis on the heterogeneity of chemoreception for mammals.

Acetylcholine↗
PubMed1991

[The reaction to hypoxia of ATP-sensitive K+ channels in rat cardiomyocytes].

The responses of ATP-sensitive K(+)-channels of the adult rat's cardiomyocytes to simulated hypoxia were found to have an oscillatory character. The degree of its blocking was found to depend on the ATP concentration at the inner side of the membrane. The concentration of the semi-maximal blocking is not more than 20 mcM. The necessity to take into consideration the local intracellular changes of the macroerg content for explanation of the revealed responses, is discussed.

Adenosine Triphosphate↗
PubMed1991

[Participation of calcium ions in carotid chemoreception].

The changes in calcium accumulation ability of glomus cells membranes under the action of alkaloids, acids and effector stimuli have been studied by fluorimetric chelate probe technique. The reception of these stimuli causes calcium-ions release mainly from the intracellular organoids membranes (mitochondrial and endoplasmatic). These data suggest that calcium-ions act as a messenger between extracellular stimuli and the metabolism of glomus cells. Results obtained provide the evidence of heterogeneity of carotid chemoreception mechanism.

Animals↗
PubMed1987

[Participation of metabolic systems of carotid chemoreceptors in their effector regulation].

Electrical stimulation of the rat sinus nerve altered fluorescence of restored pyridin nucleotides and oxidative flavoproteids in the carotid body cells due to enhancement of cellular respiration. This was followed by an increase of cGMP content in the carotid body. The greatest shifts of these parameters occurred in square-wave stimulation with 20/sec frequency. The effector influences on the carotid body metabolism are most effectively blocked with pentamine and seem to be of cholinergic nature, the transmitter effect of acetylcholine being modulated with enkephalins. The cGMP system may serve as an intermediary of the effector influences.

Animals↗
PubMed1982

[Effect of preparations altering cAMP metabolism on the bioelectrogenesis of the skeletal muscles].

In the frog isolated m. sartorius, microelectrode technique and in vivo TV microscopy differentiating bioelectrical phenomena in separate fibers of different groups (dark, light, intermediate), revealed that the drugs altering cAMF exchange (adrenaline, caffeine, imidazole) and used in concentration 10(-5) M, affect to different extents the resting potential and the AP. The effect of the drugs is more obvious in respect to excitatory potential. Mechanism of this phenomenon is discussed.

Action Potentials↗
PubMed1979

[Study of the "stimulus--excitation" function in the peripheral portion of the frog taste analyzer].

The intensity of glossopharyngeal nerve afferent discharges in the frog was studied during stimulation of gustatory receptors by caffeine, acetic acid, saccharose and sodium chloride ranging widely in the concentration changes. It was shown, that the function "stimulus-exitation" for the summary discharges in response on the coffeine and acetic acid was being logaryphmic. The character of off-effects dependence on the concentration of bitter and sour stimuli. Was proved to be the same. The curve "stimulus-exitation" for the saccharose was "S" shaped, but for the sodium chloride it might be described by the power function with the exponent equal 0,8.

Acetates↗