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Biomedical subjects

V Nikkanen

Publications and source records attributed to V Nikkanen.

At least 55 records · Page 3Linked to original sources
PubMed1981

Treatment results in mammary carcinoma stages I-IV.

A retrospective review of 590 patients with breast carcinoma of all clinical stages is presented. The patients were treated mainly with radical mastectomy and postoperative irradiation. The overall 5- and 10-year survival rates were 59% and 45%, in stage I 83% and 76%, in stage II 64% and 47%, in stage III 29% and 14% and in stage IV 5% and 0%, respectively. Treatment methods, prognostic factors and differentiation grade of infiltrating ductogenic carcinoma have been analysed and the effect of these factors on the treatment results in different clinical stages is presented.

Adult↗
PubMed1980

Uterine malignant degeneration after low- dose endometrial irradiation.

The effectiveness of low-dose intrauterine irradiation for benign diseases and its possible carcinogenic effect on the uterus was studied in 190 patients who were treated during the years 1952-1974. The indications for irradiation were premenopausal functional bleeding, leukemia, hemophilia, fibroids, endometriosis or other benign reason. Radiation was also performed on patients with severe neurologic diseases that contraindicated surgery and on some mentally retarded patients whose restlessness and epileptic seizures were aggravated premenstrually and during menstruation. The mean follow-up period was 15 years. Uterine bleeding recurred in 21% of the patients. No cases of uterine malignant degeneration were found.

Adolescent↗
PubMed1980

Postmenopausal endometriosis.

The frequency of postmenopausal endometriosis (ovarian endometriosis and adenomyosis) was 2.2%. The mean of the menopausal ages in 11 patients with ovarian endometriosis was 50.3 yr and the average time elapsed since menopause, 7.3 yr. The corresponding values in 8 patients with adenomyosis were 52.1 and 8.8 yr. Carcinoma was a common associated finding in patients with ovarian endometriosis. Increased estrogen activity was observed more frequently in patients with adenomyosis than in those with ovarian endometriosis. Only one of the patients had received estrogen therapy. Hormone-producing tumors in the ovaries or adrenal glands were not confirmed. 70% of the patients were obese and the signs of increased estrogen activity could be explained by extraglandular estrogen formation.

Aged↗
PubMed1980

Recurrent endometriosis.

Of 903 surgically treated patients with endometriosis the disease recurred in 132 cases (14.6%) during the follow-up period of 6-10 years. The re-operation was performed within 1 year after the primary operation for 7 patients, within 1-5 years for 91 patients and more than 5 years after the primary surgery for 34 patients. The most common complaints were pain in the lower abdomen and dysmenorrhoea and the most common sites for the recurrence the ovaries and retrocervix. Endometrioma of the rectum was surgically treated in 10 patients and endometrioma of the urinary bladder in 3. Gestagen therapy after the primary surgery had no effect on the recurrence rate.

Adult↗
PubMed1980

The significance of chlamydial genital infection in male infertility.

Chlamydia trachomatis (C.tr.) is recognized as an aetiological agent in most cases of male nonspecific urethritis, post-gonococcal urethritis, and epididymitis. According to the recent view, C.tr. is considered capable of causing infertility in women, but up to date the significance of C.tr. in male infertility is unknown. According to our study, chlamydial genital infection seems to play a role in male infertility, but in lesser degree than in females. Male chlamydial infection seems to be less intense and more "distal" than female infection. The infection is apparently often quite symptomless. The incidence of genital chlamydial infection in male population evidently increases with age and promiscuity at least from the age of 20 to 30 years.

Adult↗
PubMed1980

Clinical significance of adenomyosis.

During the years 1968--1972, 903 patients with endometriosis were operated on in the Turku University Central Hospital, of whom 136 were found to have adenomyosis (endometriosis interna). The diagnosis of adenomyosis was usually made post-operatively from following examination of uterus; only 15% were suspected to have adenomyosis preoperatively. 24% of the patients also had external endometriosis. The symptoms and the clinical finding were analysed, but the results were quite unclear and were often easier to explain in terms of other simultaneous diseases or of menopausal disturbances. Adenomyosis, unlike external endometriosis, did not cause sterility. A study of the aetiology showed that only 6% had had no pregnancies. Adenomyosis is a benign disease with little clinical significance. Its symptoms are unclear and it is usually underdiagnosed, but it may actually appear in more than 50% of parous women over the age of 40. In this study, the only aetiology of adenomyosis appeared to be pregnancy and/or delivery. Finally it is suggested that adenomyosis may be a more or less physiological finding in parous women, with the highest frequency of occurrence in the female population over the age 30 years when childbearing is generally over.

Adult↗
PubMed1979

Chlamydial serology in infertile women by immunofluorescence.

The chlamydial serum immunoglobulin G antibodies of 128 infertile women were determined by a single-antigen (L2) immunofluorescence test. The antibody titers were compared with those of female contacts of men with nonspecific urethritis and with those of "normal" pregnant women. Among infertile women, 43% lacked chlamydial antibodies (titer less than or equal to 8). The corresponding proportion for contacts of men with nonspecific urethritis was 14% and that for pregnant women 71%. A very high titer (greater than or equal to 256) was recorded in 25 infertile women and in 7% of pregnant women. Among women with positive chlamydial isolation, 46% had titers greater than or equal to 256. Bilateral tubal obstruction was demonstrated in 23 infertile women (18%). The geometric mean titer of these patients was higher than that of patients with normal hysterosalpingograms. In nine cases with bilateral tubal obstruction and very high chlamydial antibody titers, there was no history of pelvis infections. The operative findings were typical of previous salpingo-oophoritis.

Adult↗
PubMed1979

Plasma cholesterol, triglycerides, FSH and testosterone levels of normolipemic male patients with decreased fertility treated with mesterolone.

There were no changes in plasma cholesterol, triglycerides, FSH and testosterone levels of 24 healthy men treated with mesterolone for infertility during period of 6 months. The patients were normolipemic and the daily doses were 75 mg. No side-effects were noticed. Mesterolone seems to have too selective or too low androgenic effect with the doses used in order to have an influence on the lipid metabolism of men.

Adult↗
PubMed1979

Electrical activity and intraluminal pressure of the cauda epididymidis of the rat.

Smooth muscle electrical activity was recorded simultaneously with intraluminal pressure in the cauda epididymidis and epididymal vas of the rat in vitro. Spontaneous electrical activity spread over distances of several centimetres and was associated with a pressure wave recorded through an open-ended catheter in the distal cauda and epididymal vas. Transmission of pressure wave was gradually damped by filling of the catheter with spermatozoa.

Animals↗
PubMed1979

Morphology of spermatogenic arrest in man.

Spermatogenic arrest in man was studied by transillumination, phase contrast microscopy, and conventional histology. The spermatogenic arrest occurred at the late pachytene stage, and the degeneration of the germ cells could be studied more accurately with phase contrast microscopy of living cells than with conventional histology. The Sertoli cells rapidly phagocytosed the degenerating cells, which could be seen on transillumination as dark spots along the whole length of the tubule.

Follicle Stimulating Hormone↗
PubMed1978

Precipitate labour.

In Turku University Central Hospital there were 4976 deliveries in the years 1974--75. Among them there were 106 spontaneous, nonaugmented labours with a duration of two hours or less, giving an incidence of 2.1% precipitate labour. The most important aetiological factor was multiparity. 35% of precipitate labours commenced with spontaneous rupture of the membranes. The incidence of prematurity after precipitate labour was 8.5% and thus significantly (p less than 0.05) higher than in a control group, where mothers were matched according to age and parity. After precipitate labour the newborn fared as well as those in the control groups. It is our conclusion therefore, that precipitate labour need not be considered as an intrapartum risk factor, when neonatal well-being is considered.

Adult↗
PubMed1976

Acid phosphatases of the rat epididymis. I. Fractionation and substrate specificity.

Three separate acid phosphatases were found in the rat epididymal homogenate after fractionation by DEAE- and CM-cellulose chromatography as well as by electrophoresis. They differed from each other also in substrate specificity. This can possibly be utilized as an aid in their differential quantitation. Some other species including man, dog, rabbit, guinea pig and mouse also had a multiple composition of epididymal acid phosphatases.

Acid Phosphatase↗