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Biomedical subjects

V Navarro

Publications and source records attributed to V Navarro.

At least 37 records · Page 2Linked to original sources

Bioactive oleanolic acid saponins and other constituents from the roots of Viguiera decurrens.

The bisdesmoside oleanolic acid saponin, 3-0-(methyl-beta-D-glucuronopyranosiduronoate)-28-0-beta-D-glucopyranosyl-oleanolate along with nine known compounds (two diterpenic acids, one chromene, three triterpenes, one steroidal glycoside, and two monodesmoside oleanolic acid saponins), were obtained from Viguiera decurrens roots. The chemical structure of the bisdesmoside oleanolic saponin was determined by chemical and NMR spectral evidence. A mixture of monodesmoside saponins displayed cytotoxic activity against P388 and COLON cell lines (ED50= 2.3 and 3.6 microg/ml, respectively). Two of the known compounds showed insecticidal activity against the Mexican bean beetle larvae (Epilachna varivestis).

Asteraceae↗

[Aeromonas spp bacteremia: study of 12 cases and review of the literature].

Twelve cases of Aeromonas spp. bacteremia are here reviewed in adult patients occurred at our institution during a 6-year period. Three cases corresponded to patients with hematological disease and four had a solid neoplasm. The source of infection in seven patients was extra-nosocomial; infections in the five remaining patients were considered to be acquired in the hospital. In seven patients, potential portals of entry were found. The usual clinical presentation was febrile syndrome in all cases and only in two patients did the clinical picture evolve to fulminant septic shock. Speciation of microorganisms was determined in only four cases: 2 A. hydrophilia, 1 A. caviae, and 1 A. veronii. Most isolates were susceptible to aminoglycosides, cotrimozazol, phosphomycin, and quinolonos, and resistant to ampicillin. Three patients (25%) died as a result of the infection. Aeromonas spp. bacteremia represented 0.12% of blood cultures in our hospital and occurs in immunosuppressed patients although it may be reported in previously healthy individuals.

Adult↗

The political context of social inequalities and health.

This analysis reflects on the importance of political parties, and the policies they implement when in government, in determining the level of equalities/inequalities in a society, the extent of the welfare state (including the level of health care coverage by the state), the employment/unemployment rate, and the level of population health. The study looks at the impact of the major political traditions in the advanced OECD countries during the golden years of capitalism (1945-1980) -- social democratic, Christian democratic, liberal, and ex-fascist -- in four areas: (1) the main determinants of income inequalities, such as the overall distribution of income derived from capital versus labor, wage dispersion in the labor force, the redistributive effect of the welfare state, and the levels and types of employment/ unemployment; (2) levels of public expenditures and health care benefits coverage; (3) public support of services to families, such as child care and domiciliary care; and (4) the level of population health as measured by infant mortality rates. The results indicate that political traditions more committed to redistributive policies (both economic and social) and full-employment policies, such as the social democratic parties, were generally more successful in improving the health of populations, such as reducing infant mortality. The erroneous assumption of a conflict between social equity and economic efficiency, as in the liberal tradition, is also discussed. The study aims at filling a void in the growing health and social inequalities literature, which rarely touches on the importance of political forces in influencing inequalities. The data used in the study are largely from OECD health data for 1997 and 1998; the OECD statistical services; the comparative welfare state data set assembled by Huber, Ragin and Stephens; and the US Bureau of Labor Statistics.

Adolescent↗

Antimicrobial evaluation of certain plants used in Mexican traditional medicine for the treatment of respiratory diseases.

Eighteen crude extracts, including six hexanic, six chloroformic and six methanolic from six different plant species used in Mexican traditional medicine for the treatment of respiratory infections, were evaluated for potential antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, and Candida albicans. The minimal inhibitory concentration was determined for each extract using a two-fold dilution assay. The results showed that 16 crude extracts (89%) exhibited antimicrobial activity against at least one of the microorganisms tested at concentrations of 5 mg/ml or below. The extracts from Gnaphalium oxyphyllum, Gnaphalium americanum, and Crescentia alata possessed strong antimicrobial activity against the pathogens tested.

Anti-Bacterial Agents↗

New modified eremophilanes from the roots of Psacalium radulifolium.

The investigation of the chemical constituents from the roots of Psacalium radulifolium, a member of the matarique complex of medicinal plants, which includes several members of the Asteraceae, resulted in the isolation of four new modified eremophilanes: radulifolin A (4), epi-radulifolin A (5), radulifolin B (6), and radulifolin C (7), together with the known natural substances cacalol, cacalone, epi-cacalone, O-methyl-1,2-dehydrocacalol, adenostin A, decompostin, and neoadenostylone. Antimicrobial evaluation of the extracts and the isolated compounds indicated that cacalol was the major active compound.

Asteraceae↗

Citalopram versus nortriptyline in late-life depression: a 12-week randomized single-blind study.

OBJECTIVE: The aim of this single-blind study was to examine the efficacy and tolerability of citalopram compared to nortriptyline in moderate to severe major depressive patients aged 60 years or over. METHOD: In- and out-patients (N=58) with unipolar major depression were randomized to 12-week flexible dose treatment with nortriptyline or citalopram. RESULTS: No significant differences between the number of drop-outs in either group were observed, but the autonomic side-effects were significantly higher for nortriptyline than for citalopram. A significantly higher remission rate to nortriptyline than to citalopram was demonstrated, particularly if severe patients (endogenous or psychotic patients) were assessed. CONCLUSION: The remission rate to a therapeutic plasma level of nortriptyline appears to be higher than the remission rate to a standard dose of citalopram in a group of elderly major depressed patients, especially those with endogenous or psychotic features. On the other hand, citalopram appears to be better tolerated.

Age of Onset↗

QT prolongation associated with azithromycin/amiodarone combination.

Administration of oral azithromycin, in addition to previously well-tolerated long-term amiodarone therapy, was associated with a marked prolongation of QT interval and increased QT dispersion, both substrates for life-threatening ventricular tachyarrhythmia and torsades de pointes. This is a report of QT prolongation and increased QT dispersion associated with the use of azithromycin. The report assumes an added significance, in view of widespread empirical use of this antibiotic for the treatment of lower respiratory infections and belief of its safety in patients with cardiac diseases. Based on the authors' experience, they would like to emphasize that the combination of azithromycin with other drugs known to prolong QT or causing torsades de pointes be used with caution until the question of the proarrhythmic effect of azithromycin is resolved by further studies.

Aged↗

SC-1, an antimycotic spirostan saponin from Solanum chrysotrichum.

A new antimycotic steroidal saponin named SC-1 has been isolated from the leaves of Solanum chrysotrichum by bioassay-guided fractionation. The structure of SC-1 was characterized as 3-O-[beta-quinovopyranosyl(1-->6)-beta-glucopyranosyl(1-->6)-beta- glucopyranosyl]chlorogenin on the basis of spectral analyses and chemical evidence.

Antifungal Agents↗

Characterizing neurodynamic changes before seizures.

The study of dynamic changes in neural activity preceding epileptic seizure allows the characterization of a preictal state several minutes before seizure onset. This opens up new perspectives for studying the mechanisms of epileptogenesis as well as for possible therapeutic interventions, which represent a major breakthrough. In this review the authors present and discuss the results from their group in this domain using nonlinear analysis of brain signals, as well as the limitations of this topic and current questions.

Animals↗

The political context of social inequalities and health.

This analysis reflects on the importance of political parties, and the policies they implement when in government, in determining the level of equalities/inequalities in a society, the extent of the welfare state (including the level of health care coverage by the state), the employment/unemployment rate, and the level of population health. The study looks at the impact of the major political traditions in the advanced OECD countries during the golden years of capitalism (1945-1980)--social democratic, Christian democratic, liberal, and ex-fascist--in four areas: (1) the main determinants of income inequalities; (2) levels of public expenditures and health care benefits coverage; (3) public support of services to families; and (4) the level of population health as measured by infant mortality. The results indicate that political traditions more committed to redistributive policies (both economic and social) and full-employment policies, such as the social democratic parties, were generally more successful in improving the health of populations. The erroneous assumption of a conflict between social equity and economic efficiency is also discussed. The study aims at filling a void in the growing health and social inequalities literature, which rarely touches on the importance of political forces in influencing inequalities.

Community Health Planning↗

The new conventional wisdom: an evaluation of the WHO report, Health Systems: Improving Performance.

The World Health Organization's recent report, Health Systems: Improving Performance, has been highly visible in the professional and popular media. The report evaluates the world's health care systems according to three characteristics--effectiveness, responsiveness to users, and the progressivity of their funding--then uses these evaluations to rank countries by each of these characteristics and by an overall indicator of performance, a composite of all three characteristics. The ranking has been widely cited, but rarely subjected to scientific scrutiny. This article analyzes the concepts and methods used in the study and the assumptions and values inherent in the report. The author demonstrates how the report's uncritical acceptance of what has become the new conventional wisdom on health and medical care policies in the United States and other developed countries seriously limits its value.

Benchmarking↗

Health and social security reforms in Latin America: the convergence of the World Health Organization, the World Bank, and transnational corporations.

International financial institutions have played an increasing role in the formation of social policy in Latin American countries over the last two decades, particularly in health and pension programs. World Bank loans and their attached policy conditions have promoted several social security reforms within a neoliberal framework that privileges the role of the market in the provision of health and pensions. Moreover, by endorsing the privatization of health services in Latin America, the World Health Organization has converged with these policies. The privatization of social security has benefited international corporations that become partners with local business elites. Thus the World Health Organization, international financial institutions, and transnational corporations have converged in the neoliberal reforms of social security in Latin America. Overall, the process represents a mechanism of resource transfer from labor to capital and sheds light on one of the ways in which neoliberalism may affect the health of Latin American populations.

Commerce↗

Science or ideology? A response to Murray and Frenk.

The WHO's World Health Report 2000, entitled Health Systems: Improving Performance, and Christopher Murray and Julio Frenk's replies to Vicente Navarro's critique of that report, reproduce an unawareness of the errors inherent in using a synthetic indicator such as overall health systems performance: the complexity and difficulty in selecting and weighting the many individual indicators that are to be included in the final, overall indicator. Decisions about how to weight the importance of the various components of the overall indicator and the sources used to select information on those components reproduce a set of highly questionable assumptions and heavily loaded ideological choices that weaken the scientific credibility of the overall indicator and of the WHO report itself. This transforms the report into a political ideological document that simply conveys and perpetuates the current conventional wisdom in health policy.

Delivery of Health Care↗