Biomedical subjects
Publications and source records attributed to V Nair.
Tardive dystonia is a rare late-onset side effect of neuroleptics. This paper presents a prevalence study of 351 inpatients conducted in our hospital. Seven patients (2%) were found to suffer from this condition. The majority were found to be young and had received neuroleptics for a variable number of years before the onset of the dystonia. In general, treatment of this condition is disappointing.
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Thirty-five bipolar outpatients treated with lithium carbonate were followed for up to 5 years with the aim of studying the relation of the lithium ratio (LR) and its predictive value. Only male responders were found to have higher LR than male nonresponders. No difference was found between the mean LR of men and women, as a group. Aging also had no effect on LR. Positive family history of affective disorders was correlated with high LR, irrespective of response.
Laboratory methods are used for the rapid identification of nine sexually transmitted diseases. Some problems are inherent in those methods. Alternate approaches can be used in the laboratory.
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The recommended prophylactic lithium levels in the treatment of manic depressive patients differ from study to study. In this paper, we present a patient who was maintained euthymic on lower plasma levels than those recommended. However, we theorize that the reason for this may be due to the fact that she had a high RBC/plasma ratio. We recommend that in those patients whose plasma lithium levels are consistently low, this point should be kept in mind before considering them as noncompliant.
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A novel structural analogue of cyclic AMP has been synthesized. This compound has been found to activate protein kinase from skeletal muscle (Ka 5.0 microM). It is virtually resistant to degradation by beef heart cAMP phosphodiesterase. It is an inhibitor of this enzyme with an [I]50 of 47.0 microM. The proliferation of cancer cells (HT-29) is inhibited by this compound. It represents the first example of a 2',3'-cyclic nucleotide with marked biological activity.
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