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Biomedical subjects

V N Serov

Publications and source records attributed to V N Serov.

At least 19 recordsLinked to original sources
PubMed2003

Effects of a phasic oral contraceptive containing desogestrel on facial seborrhea and acne.

BACKGROUND: The combined oral contraceptive containing ethinylestradiol and the selective progestogen, desogestrel, in a phasic regimen (DSG-OC, Tri-merci) has been shown to reduce facial oiliness. OBJECTIVE: This study was designed to evaluate further the effects of this OC on the skin of women with facial seborrhea and mild or moderate acne. DESIGN AND METHODS: This was an open, noncomparative, bicenter study in 60 healthy Russian women, aged 18-30 years, with facial seborrhea and mild or moderate facial acne, who wished to use oral contraception. All women received the OC containing desogestrel (50/100/150 microg) and ethinylestradiol (35/30/30 microg) for three phases of 7 days followed by a 7-day pill-free interval, for six cycles. Seborrhea was assessed using the Sebutape technique, in which strips of adhesive microporous polymeric film pressed onto facial sites are used to assess sebaceous activity. Acne was assessed by counting facial lesions. Subjective evaluations of skin and hair condition, patients' feelings to them and satisfaction with the OC were made using a visual analogue scale (VAS). Assessments were made at baseline, and after one, three and six treatment cycles. RESULTS: Sebutape assessments of seborrhea were significantly improved, on the right and left cheeks, after one treatment cycle, and on the forehead after three treatment cycles. These improvements increased steadily and were much larger at the end of Cycle 6. Acne grades were significantly improved after three and six treatment cycles. VAS scores in response to questions dealing with self-esteem and self-confidence were significantly improved after three cycles and in some cases after just one cycle. The women's views of their skin and hair (greasiness) were correspondingly significantly improved. Subjective assessments indicated that after one, three and six cycles, 69%, 93% and 98%, respectively, of women were satisfied or very satisfied with the DSG-OC. CONCLUSION: In women with facial seborrhea and mild or moderate acne, the use of DSG-OC appears to improve seborrhea after just one cycle and acne grades after three cycles. These improvements are accompanied by increases in self-esteem and confidence.

Acne Vulgaris↗
PubMed1999

NetWork: an interactive interface to the tools for analysis of genetic network structure and dynamics.

We designed a Java applet called NetWork which enables a user to interactively construct and visualize a genetic network of interest, and to and to evaluate and explore its dynamics in the framework of a Boolean network model. NetWork displays the mechanism of gene interactions at the level of gene expression and enables the visualization of large genetic networks. NetWork can serve as an interactive interface to tools for the analysis of genetic network structure and behavior.

Algorithms↗
PubMed1998

Graphical interface to the genetic network database GeNet.

UNLABELLED: We designed a Java applet which enables the visualization of genetic networks and can be used as a Web publishing tool by molecular biologists studying the mechanisms of gene interactions. AVAILABILITY: http://www. csa.ru/Inst/gorb_dep/inbios/ genet/Graph/Genes_Graph.html CONTACT: samson@fn.csa.ru

Computational Biology↗
PubMed1997

[Endotoxin and antiendotoxin immunity in pelvioperitonitis].

The levels of bacterial blood endotoxin, antiendotoxin antibodies and the overall immunity were studied in 48 females with inflammatory genital diseases complicated by pelvioperitonitis. The severest pelvioperitonitis-complicated abnormality was shown to characterized by high concentrations of endotoxin and low levels of antibodies. Endotoxinemia was found to be of diagnostic and prognostic value.

Adult↗
PubMed1994

[Hyperplastic ovarian processes from the clinico-morphological aspect].

Clinico-morphologic analysis was carried out in 93 patients with hyperplastic changes in the ovaries (stromal hyperplasia, thecomatosis, interstitial gland, etc.) and endometrial hyperplasia (glandular, atypical, etc.). A relationship was revealed between endometrial hyperplasia and ovarian hormone-producing structures, but the intensity of proliferation and structural rearrangement of glandular epithelium did not correlate with the activity of gonadal hormone-producing structures determined by morphofunctional studies, nor did it correlate with blood plasma estradiol level. Ineffective hormonal therapy of patients with hyperplasia of the endometrium may be caused by hyperplastic processes in the ovaries.

Adult↗
PubMed1993

[Reserves in decreasing maternal mortality due to obstetrical hemorrhages].

Analysis of 542 lethal cases at pregnancy terms 28 weeks and more, of parturients and puerperae in Russia over 1987-1991 has shown that obstetrical bleedings were responsible for 42.2% of deaths, being the most frequent causes of lethal outcomes. Analysis of records documenting 283 lethal cases has shown a high incidence of somatic (90.9%) and obstetrical diseases (95.5%). Assessment of medica care quality has shown inadequate care of pregnant women and parturients and inadequate emergency care. Prevention of massive blood loss should involve hemostasis studies in pregnant women and parturients and its correction; if a bleeding occurs, comprehensive intensive care and surgical interventions are indicated.

Adolescent↗
PubMed1992

[Congenital cytomegalic inclusion disease--clinico-anatomical characteristics].

Analysis of labor histories, case histories, and autopsy records over a decade, 1980-1990, has revealed 32 cases of cytomegalic inclusion disease in children. Eleven placentas of seropositive mothers were histologically examined. The findings evidence that cytomegaloviral infection was mostly combined with other bacterial and viral diseases. The central nervous system, kidneys, and lungs were the most sensitive to the virus effects. The DIC syndrome was present in all the cases.

Cytomegalovirus↗
PubMed1991

[Effects of prenatal factors on the colloid-osmotic status of the newborn].

Studies of prenatal factor effects on the newborns' colloid-osmotic status, a pressing problem in present-day obstetrics, were carried out in 2 groups of women: Group 1 consisted of 50 women with spontaneous delivery and Group 2, also consisting of 50 women, who delivered via cesarean section, 25 of them because of a cicatrix on the uterus and the rest because of severe gestoses characterized by nephropathy and Stage III pre-eclampsia. Blood samples were collected directly after delivery from the mother's vein and from the newborn's umbilical vein, and the colloid-osmotic status of the plasma was analyzed. The results permitted singling out a number of prenatal factors influencing the newborns' colloid-osmotic status. These factors are as follows: obstetrical abnormalities, gestosis among other things; intensive care of the mother during delivery or after surgery, administration of diuretics, delivery mode, etc. These results have brought the authors to a conclusion that standardized infusion therapy without due consideration for the colloid-osmotic status is inadmissible, for it may result in iatrogenic complications in the newborns.

Adult↗
PubMed1991

[Informative value of various biochemical parameters of homeostasis in the formation of endometrial cancer risk groups].

A total of 97 patients suffering from endometrial polyposis, hyperplasia, adenomatous hyperplasia, and carcinoma were examined. The levels of malonic dialdehyde as an index of lipid peroxidation, average-mass molecules, C peptide, humoral immunity parameters were studied. The content of circulating immune complexes were also determined. Specific changes which might be an auxiliary factor in predicting the therapy and forming cancer risk groups were identified.

C-Peptide↗
PubMed1990

[Measurement of the oncotic pressure of blood (methodology and analysis of errors)].

The authors give their practical recommendations on improving the accuracy of the blood plasma colloid osmometry by standardizing the methods for the collection, treatment, and storage of the samples and the oncometry procedure per se. The recommendations are based on literature data and the authors' experience.

Blood Physiological Phenomena↗
PubMed1990

[Characteristics of infusion therapy in parturients with gestosis after cesarean section].

The paper addresses fluid therapy after cesarean section in toxemic parturients. A comparative study involved 130 parturients and 540 women with a history of toxemia of pregnancy of variable severity. It was demonstrated that the routine fluid therapy employed in women with mild toxemia was not suitable for parturients with Grade III pregnancy-associated renal disease and preeclampsia. This is explainable by 3 types of abnormality in the colloid oncotic pressure (hyper-, hypo- and normo-osmolar++ dysosmia); most of the patients presented with hypo-osmolar and hypo-oncotic++ plasma states coexisting with impairment of renal excretory and concentrating function.

Blood Transfusion↗
PubMed1990

[Clinico-morphological characteristics of fetuses and newborn infants of mothers with hemorrhagic shock].

A clinical and morphological analysis has been done using 24 obstetric histories of mothers with hemorrhagic shock (HS) and autopsy protocols of fetuses and newborns who died ante-, intra- or postpartum. Maternal HS was related to placenta previa and presented as a poor general status and microcirculatory disorders, respiratory and adrenal insufficiency. Histologic and electron microscopic studies showed fetal and neonatal lesions in organs and tissues which might be interpreted as irreversible shock. Reduction of neonatal mortality dictates further efforts in the prevention of hemorrhagic complications in parturients.

Adult↗
PubMed1990

[Stress normal values of the indicators of colloid osmotic pressure in parturients after cesarean section].

The paper describes changes in mineral and protein metabolism and renal function in mothers with an uncomplicated ++post-cesarean course. Stress norms of mothers delivered by cesarean section were quantitatively different from those of surgical patients: the former had lower values of osmolality and glucose levels and a marked reduction in total protein and albumin levels. This warrants fluid therapy controlling for the changes induced by the operation.

Cesarean Section↗
PubMed1990

[Birth injuries and lesions of the spinal cord in the perinatal period].

The paper presents a clinical and pathological analysis of 40 deliveries, autopsy findings in fetuses and newborns with combined birth injury of the brain and spinal cord, perinatal disease entities associated with intrapartum spinal lesions and disease entities which entail secondary spinal lesions. A subgroup of newborns with intraventricular hemorrhage showed at autopsy diffuse subarachnoidal hemorrhage of the cervical and thoracic spinal segments as a function of its extension into the cerebrospinal fluid system. Guidelines for pathological diagnosis in the pediatric practice are offered.

Birth Injuries↗
PubMed1989

[Mitral commissurotomy during pregnancy].

Relying on studies into the features of the gestation course, immediate and late results, instrumental investigation findings in 91 patients with mitral stenosis prior to a surgery and in the readaptive period, indications and relative contraindications for mitral commissurotomy during pregnancy were specified and supplemented. Differential strategy was also developed for delivery of such patients.

Delivery, Obstetric↗