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Biomedical subjects

V N Letov

Publications and source records attributed to V N Letov.

36 records · Page 2Linked to original sources
PubMedDate not supplied

[The effect of membrane-active compounds on the radiation-modifying effect of glucose in x-irradiated ascitic tumor cells].

A study was made of the influence of membrane-active agents with different mechanisms of action (quercetin, amiloride, valinomycin, and digitonin), that modify the transmembrane transfer of inorganic ions, on a modifying effect of a glucose loading in X-irradiated Ehrlich ascites tumor cells. The combination of digitonin with glucose increased the damaging effect of radiation on tumor cells by 1.8-2.2 times as compared to glucose alone. Merely insignificant changes in the radiation-modifying effect of glucose were observed when it was combined with other membrane-active agents.

Amiloride↗
PubMedDate not supplied

[Effect of hydrocortisone and insulin on changes of oxidative phosphorylation after neutron irradiation].

Total double irradiation of rats with a fast neutron flow does not affect oxidative phosphorylation in the liver mitochondria but causes an essential decrease in the intensity of phosphorylation in mitochondria and chemoluminescence in blood serum of animals. Postradiation multiple administration of hydrocortisone intensifies the radiation inhibition of oxidation and phosphorylation of mitochondria and insulin administration stimulates phosphorylation in the liver mitochondria and the intensity of chemoluminescence in blood serum of rats. Hydrocortisone in combination with insulin has a less pronounced stimulating effect on phosphorylation than insulin, but the intensity of chemoluminescence in this case is higher than under the effect of each preparation separately.

Animals↗
PubMedDate not supplied

[Effect of insulin on oxidative phosphorylation in the liver and heart mitochondria of adrenalectomized rats].

The effect of insulin was studied as applied to the inhibited under conditions of adrenalectomy process of oxidative phosphorylation in the rat liver and heart mitochondria. It is established that adrenalectomy does not change oxidative activity of mitochondria but inhibits the process of phosphorylation, which results in the decreased values of the ADP/O coefficient and the respiratory control. Insulin administered to the adrenalectomized rats 3h before the experiments reduces the disturbed oxidative phosphorylation in mitochondria of the liver and heart by intensifying the degree of ADP phosphorylation.

Adenosine Diphosphate↗
PubMedDate not supplied

[Radiosensitivity of resting and proliferating cells irradiated with fast neutrons].

The influence of 6 MeV neutrons on the duration of the cell cycle and DNA biosynthesis was studied in rat regenerating liver cells irradiated at G0-(resting cells) and G1-stages (proliferating cells). It was demonstrated that neutron irradiation of the proliferating cells caused deeper changes both in the duration of the cell cycle and in inhibition level of DNA biosynthesis, than irradiation of the resting cells.

Animals↗