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V Molina

Publications and source records attributed to V Molina.

At least 73 records · Page 4Linked to original sources
PubMed1987

Inhibition of mouse killing behavior by serotonin-mimetic drugs: effects of partial alterations of serotonin neurotransmission.

Rats which do not kill mice and which acquire mouse killing behavior after partial lesion of the serotonin neurotransmission, either by p-chlorophenylalanine treatment or by electrolytical lesions of dorsal and median raphe nucleus, were treated by IP injection of serotonin-mimetics. The following drugs were used: 5-methoxy-N-N-dimethyl-tryptamine and 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, serotonin-agonists, fluoxetine and citalopram, inhibitors of serotonin uptake. All these serotonin-mimetics inhibit mouse killing behavior without apparent secondary effects. When these compounds were tested on killer rats, a stronger antimuricidal effect was observed in rats having altered serotonin neurotransmission. These results support a role for the serotoninergic supersensitivity in a model of aggressive behavior.

8-Hydroxy-2-(di-n-propylamino)tetralin↗
PubMed1987

[Simultaneous determination of total and immature neutrophil C-reactive protein in normal, diseased, and infected newborn infants].

C. reactive protein and immature neutrophils/total neutrophils ratio are measured in 146 newborns. Three groups are considered: 37 healthy, 90 pathologic non infected and 19 bacteriologically confirmed infected newborns. Pathologies other than infection do not alter CRP nor I/T. Levels lower than 20 mg/l for CRP and 0.18 for I/T are considered normal. Both tests are considered very useful for neonatal infection diagnosis (p less than 0.001). CRP shows a higher sensitivity than I/T in neonatal infection diagnosis even in its initial period (84% versus 63%).

Bacterial Infections↗
PubMed1986

Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.

Intra olfactory bulb administration of three classes of GABA-mimetics (GABAa agonists, inhibitors of reuptake, inhibitors of GABA degradation) clearly inhibit mouse-killing behavior, without sedation. A linear correlation is observed between GABA levels increase in the olfactory bulbs and muricidal inhibition following local injection of valproic acid and gamma-vinyl GABA, two GABA-T inhibitors; the differences observed between these two compounds may be due to the differences in their mechanism of action on GABA-T activity and to the different pool of GABA on which they act. No diffusion to extra bulbar sites were observed after local administration of gamma-vinyl GABA. This evidence suggests an inhibitory role of GABA from olfactory bulbs in the modulation of mouse-killing behavior.

Aggression↗
PubMed1983

Characterization of the 42-S nucleoprotein particles of Cyprinus carpio oocytes.

Previtellogenic oocytes of the fish Cyprinus carpio contain 42S nucleoprotein particles that are composed of two proteins of molecular weights 48,500 and 39,300 (molar ratio 2:1), tRNA and 5S RNA (molar ratio 3:1). The tRNA population embodied in the 42S particle contains all amino acid acceptor species but their distribution differs from that found in tRNA from mature oocytes.

Amino Acids↗
PubMed1982

[Perinatal histories of 22 newborns with malformations of the central nervous system].

The authors reviewed the perinatal histories of 22 newborns malformations of the central nervous system, among 9,323 consecutive births in the last five years, with particular emphasis on the incidence and types of malformations, as well as the most important findings of the parents anamnesis. Prenatal ultrasonography is stressed out as an important tool in the precocious diagnosis of such a kind of malformations.

Adult↗
PubMed1980

ELISA for toxoplasma antibody detection: a comparison with other serodiagnostic tests.

An ELISA method was developed for the measurement of toxoplasma IgG antibodies in human serum using antigen-coated polystyrene beads as a solid phase and anti human IgG-horse radish peroxidase conjugate as an enzymatic tracer. In order to assess ELISA sensitivity and specificity, a between methods comparison was made using 'conventional' serological tests as reference (dye-test, crossover-linked immunoassay, passive haemagglutination, indirect immunofluorescence). From an analysis of the group classifications obtained some considerations emerged: the ELISA specificity looks comparable with that of the 'reference' tests, as no sample classified as negative by all these tests was ELISA-positive, and vice versa; ELISA appears to correlate better with haemagglutination and immunofluorescence, on the basis of the respective class frequencies; in particular, the number of positives, which is much lower for the dye-test and crossover-linked immunoassay, suggests that a higher sensitivity is reached in the former cases.

Antibodies↗
PubMed1980

[Pulmonary edema associated with Pseudomonas neonatal sepsis (author's transl)].

Four newborn babies at term, with massive pulmonary haemorrhage associated with fulminant septicemia due to pseudomonas, are presented. The neonates died in the first day of life. The haematocrit and the proteic contents of the pulmonary effluent showed the existence of a pulmonary lesional edema. The histological findings in the four cases support this hypothesis. A revision of the etiopathogenic possibilities of the noncardiogenic pulmonary edema in the neonate is presented.

Female↗
PubMed1980

[Persistance of fetal circulation. a case associated to maternal indomethacin administration (author's transl)].

The case of a neonate born to a mother who was treated with indomethacin in the antenatal period is presented. Newborn presented, immediately after birth, severe respiratory distress syndrome, with cyanosis that remain unmodified by oxigenotherapy and mechanical ventilation. Clinical picture and analitic and radiographic findings, suggested persistent fetal circulation syndrome. It has been recently demonstrated that indomethacin is able to affect hemodynamic changes in neonatal period avoiding arteriolar dilatation and consequently, the fall of pulmonary vascular resistences. Administration of tolazoline was followed of rapidly improvement of the patient.

Female↗
PubMed1979

Ventilator modifications for intermittent mandatory ventilation.

A Loosko MK2 ventilator has been modified to provide IMV in newborns. IMV rate can be varied from 3-60/min. The minimum inspiration period can be theoretically as low as 0.1 sec. This modification in neonatal mechanical ventilation has been shown to be economically feasible.

Humans↗
PubMed1979

Effects of the administration of artroglobina suppositories in healthy volunteers.

Forty-nine healthy volunteers were treated daily with Artroglobina suppositories (anticartilage antiparathyroid immunoglobulins) for twelve days, in order to prove the absence of side effects. Volunteers were examined daily. Blood and urine samples were taken before the treatment, twelve days, twenty-four days and six months after the beginning of the treatment. Slight changes were noted in some parameters though remaining in the normal range and disappearing six months later. No symptoms of intolerance, toxicity or side effects were registered.

Adolescent↗
PubMedDate not supplied

Prior morphine facilitates the occurrence of immobility and anhedonia following stress.

The role of the activation of the opiate system either induced by a 120-min restraint session or by a single morphine administration (10 mg/kg, i.p.) on the behaviors performed in a subsequent forced-swim test has been evaluated. In addition, animals were pretreated with naloxone (2 mg/kg, i.p.) prior to restraint or to morphine. Furthermore, in order to evaluate if this opioid mechanism could participate in the effect of stress on the response to a rewarding stimulus, rats were administered with morphine (10 mg/kg, i.p.)--whether associated or not with prior naloxone (2 mg/kg, i.p.) administration--and subsequently exposed to a 90-min restraint period. Following stress, all rats were submitted to a sucrose (1%) preference test. Both morphine and restraint enhanced the time spent in immobility in the forced-swim test. Both behavioral effects were attenuated by naloxone pretreatment thus suggesting that the increased immobility is probably modulated by the previous activation of an opiate mechanism. Furthermore, only animals with the associated treatment with morphine and restraint showed a clear reduction in sucrose preference. The fact that this effect was blocked by naloxone suggests the involvement of an opiate process in this decreased response to reward. These behavioral data suggest that the activation of an endogenous opiate mechanism facilitates the occurrence of enhanced immobility and anhedonia in response to a subsequent stress experience.

Animals↗
PubMedDate not supplied

Antioxidant effects of D002 on the in vitro susceptibility of whole plasma in healthy volunteers.

BACKGROUND: It has been recently shown that oral administration of D002, a mixture of higher aliphatic primary alcohols isolated from beeswax, inhibits rat microsomal lipid peroxidation. This justified the present attempt to investigate whether D002 also exerts antioxidant effects in humans. METHODS: The effects of D002 on lipid peroxidation were studied in a double-blind, randomized, placebo-controlled trial conducted in 50 healthy volunteers. Unfractionated plasma samples at baseline and at 12 weeks were subjected to in vitro copper-induced lipid peroxidation and conjugated diene generation was monitored by changes of optical density. RESULTS: The oral treatment with D002 (50 mg/day) not only significantly prolonged (p <0.001) lag time before the onset of conjugated diene formation compared with that of baseline but also increased (p <0.05) lag phase when compared with placebo group. In fact, in the D002 group the lag-phase of oxidation was prolonged 1.5-fold. D002 oral treatment decreased TBARS and increased plasma total antioxidant status (TAS) (p <0.01). CONCLUSIONS: Because prooxidant states have been linked to normal senescence and some age-related diseases, the present data suggest that D002 may find a use in preventing age-related diseases as a dietary natural antioxidant supplement.

Administration, Oral↗