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Biomedical subjects

V Mishra

Publications and source records attributed to V Mishra.

53 records · Page 3Linked to original sources
PubMed1994

Necrotizing enteritis simulating Pig-Bel disease in northern India.

OBJECTIVE: A clinicopathological study of patients presenting with necrotizing enteritis, similar to the Pig-Bel disease of Papua New Guinea. METHODS: A clinicopathological study of 95 patients presenting in last ten years with acute abdominal pain with diarrhea and/or bleeding per rectum and vomiting and found to have lesions similar to Pig-Bel disease. RESULTS: 89% of the patients were young adult vegetarians from lower socio-economic strata. 94% of cases presented between May and August every year showing a marked seasonal variation. Jejunum was the most common site (95%) involved. Gross examination showed blackish brown 'skip' lesions with gangrene and perforations. Histology showed marked necrosis and congestion of all the layers with mucosal ulcerations. CONCLUSION: A disease simulating Pig-Bel disease occurs in India. It is more common in young adult vegetarians and may have a different etiology from that proposed in endemic regions.

Adolescent↗
PubMed1993

Prolonged peritoneal dialysis in acute renal failure using Tenckhoff catheter.

The changing spectrum of acute renal failure (ARF), in children has necessitated the support by peritoneal dialysis (PD) for a longer duration. Use of permanent catheters like Tenckhoff catheter can overcome many of the problems associated with the prolonged use of temporary catheters. Thirty one infants and children with mean (SD) age of 49.3(39.4) months were subjected to PD using surgically placed Tenckhoff catheter. Catheters were put under general anesthesia in 28 patients and under local anesthesia in 3 patients. The technique of catheter insertion has been described in detail. All the catheters, except one, functioned immediately after the insertion. There was no intraperitoneal hemorrhage, dialysate leak or poor catheter drainage. The mean (SD) duration of catheter placement for PD was 11.3 (16.1) days (range 2.90 days). There were 6 episodes of infections (19.2%), peritonitis in 4 (12.8%) and exit site infection in 2 (6.4%). In 2 patients, infection episodes did not respond to antibiotics and the catheter had to be removed. There was no mortality due to complications of PD procedure and catheter insertion. Acute intermittent PD using surgically placed Tenckoff catheter was done safely for prolonged duration and also had additional advantages of good catheter drainage and no intraperitoneal hemorrhage.

Acute Kidney Injury↗
PubMed1992

Screening of a Babesia bigemina cDNA library with monoclonal antibodies directed to surface antigens.

A Babesia bigemina cDNA library prepared in lambda ZAP bacteriophage vector was immunoscreened to detect clones expressing surface-exposed epitopes of B. bigemina. A nonradioactive indirect plaque-lift immunoassay was used to detect the positive clones. The primary antibody consisted of a pooled sample of six monoclonal antibodies (mAb) specific for B. bigemina that recognizes various parasite surface antigens of different molecular mass. Screening of approximately 300,000 plaque-forming units from the lambda ZAP cDNA expression library resulted in the identification of five positive clones. The five recombinant clones were immunoscreened individually with each of the six mAb. All five independently obtained clones consisted of lambda ZAP recombinants expressing B. bigemina components recognized by mAb C2F3G3 and B1B3C4. Restriction enzyme digests of rescued recombinant phagemids showed that only four clones contained B. bigemina cDNA. One clone (lambda ZAP Bbi1) contained an insert of approximately 0.6 kBp whereas the other three clones (lambda ZAP Bbi2, lambda ZAP Bbi3, and lambda ZAP Bbi5) carried a cDNA insert of approximately 1.7 kBp. Immunoblotting of protein extracts from recombinants lambda ZAP Bbi2, lambda ZAP Bbi3, and lambda ZAP Bbi5 with mAb C2F3G3 and B1B3C4 demonstrated the expression of a recombinant B. bigemina polypeptide of 55 kDa in E. coli.

Animals↗
PubMed1990

Value of serum prolactin in differentiating epilepsy from pseudoseizure.

We studied the serum prolactin levels in 35 cases with various types of seizures viz. generalized tonicolonic seizures (GTC), complex partial seizures (CPS), and simple partial seizures (SPS). We also studied 20 cases with pseudoseizure (hysteria) presenting in an epileptiform manner. Twenty two normal healthy subjects were also studied. All the cases were studied both in the postictal and interictal periods. Serum prolactin rose significantly in the postictal periods in patients with GTC and CPS, but patients with SPS or pseudoseizure did not demonstrate this rise. Thus serum prolactin estimation can be of help in differentiating true generalized seizures from pseudoseizure presenting in an epileptiform manner.

Diagnosis, Differential↗
PubMed1983

IgA deposits in skin in alcoholic liver disease.

IgA deposition in the liver in a characteristic continuous pattern is a consistent finding confirming the diagnosis of alcoholic liver disease. This study demonstrates a correlation between characteristic IgA deposition in the liver and IgA deposition in and around superficial dermal capillaries in alcoholic liver disease. Simultaneous liver and skin biopsies from nineteen patients with established alcoholic liver disease and eight patients with nonalcohol-related diseases of the liver were studied using standard immunofluorescent and immunoperoxidase methods. Fourteen of the nineteen alcoholic patients showed the characteristic pattern of IgA deposition in the liver, twelve of these fourteen patients showed IgA deposits in and around superficial dermal capillaries, and of these twelve patients, nine showed concurrent deposits of C3 in the skin capillaries. None of the eight nonalcoholic control patients showed either characteristic liver IgA deposits or any dermal deposits. Biopsy of clinically normal skin can be of adjunctive aid in the confirmation of alcoholic liver disease.

Biopsy↗
PubMedDate not supplied

Resolving appendicitis: role of CT.

BACKGROUND: We assessed the role of computed tomography (CT) in the resolution of appendicitis. METHODS: This was a retrospective study over 2.5 years involving 155 patients and 172 CT scans for suspected appendicitis in an emergency setting. RESULTS: Sixty-nine studies were positive for appendicitis by CT criteria. Of these, 53 underwent surgery: 48 were positive for appendicitis, four had other pathologies (two with colon cancer, one with colitis, one with infectious enteritis), and one had a normal appendix that was removed. Three of the 69 patients were released or left the emergency room against medical advice. Twelve patients demonstrated acute appendicitis by CT criteria but were treated conservatively because their clinical conditions were stable; four of those patients had follow-up CT that showed resolution of findings. Six patients were followed clinically, without recurrence of symptoms, and two were lost to follow-up. CONCLUSION: Resolving appendicitis is an entity that should be considered in a patient who has signs positive for appendicitis on CT but is doing well clinically. CT positive for appendicitis does not necessarily indicate surgery, and the decision for operation should depend on clinical and radiologic features.

Acute Disease↗
PubMedDate not supplied

Analgesic activity of thioureido derivatives of arylsemicarbazones.

The synthesis of a series of novel arylsemicarbazones derived from 4-aminoacetophenone and their evaluation for analgesic activity are described. The p-chloro-substituted derivatives (12-15) are extremely potent compounds as compared to standard drugs currently being used.

Analgesics, Non-Narcotic↗
PubMedDate not supplied

Anticonvulsant activity of p-chlorophenyl substituted arylsemicarbazones--the role of primary terminal amino group.

A series of p-chlorophenyl substituted arylsemicarbazones were synthesized and evaluated for anticonvulsant activity. Most of the compounds provided significant protection against maximal electroshock-induced seizures (MES) at 100 mg/kg after 0.5 h and at 300 mg/kg after 4 h in both MES and pentetrazole-induced (PTZ) seizures. In the strychnine-induced seizures (scSTY), the majority of the compounds showed protection at 30 mg/kg. The compound 2 was active in both MES and PTZ tests. The study has shown that the terminal primary amino group is not necessary for anticonvulsant activity.

Animals↗
PubMedDate not supplied

Regional variations in the female age at marriage in India: an analysis by agro-climatic zones.

"The effect of agro-climatic factors on female age at marriage [in India] is studied by carrying out areal analysis of the 1981 Census data. The study found a close association between agricultural and climatic conditions in an area and corresponding female age at marriage. In general, women in Himalayan regions and coastal areas have higher age at marriage than most hinterland regions. Rainfall, altitude, forest area, land availability and productivity are observed to be associated with female age at marriage. In addition, female age at marriage in rural areas is found to be more sensitive to the agro-climatic conditions. It is hypothesized that with socio-economic and technological development, the agricultural and climatic factors are losing their grip on female age at marriage in India."

Agriculture↗
PubMedDate not supplied

Effect of centrally administered angiotensin on urine output in dogs.

The effect of angiotensin II was studied on urine volume, urine sodium and potassium sodium and potassium in mongrel dogs. Intracerebro-ventricular (icv) administration of angiotensin (100.0 micrograms) caused significant increase in urine volume without significant change in urine sodium and potassium level. Similar effect is also obtained in denervated dogs. The effect of intracerebroventricularly administered angiotensin is possibly due to the decrease in secretion of the Antidiuretic hormone (ADH) from posterior lobe of pituitary gland.

Angiotensin II↗