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Biomedical subjects

V Mendel

Publications and source records attributed to V Mendel.

16 recordsLinked to original sources
PubMed1999

Therapy with hyperbaric oxygen and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats.

Hyperbaric oxygen (HBO2) is used as adjunctive therapy for chronic osteomyelitis, yet its efficacy remains controversial. A recently developed rat model for osteomyelitis due to Staphylococcus aureus was used to compare the results of treatment with HBO2, cefazolin, a combination of both, or no treatment. For the induction of tibial osteomyelitis, S. aureus was inoculated into the medullary cavity. Arachidonic acid was used as the sclerosing agent. With that procedure, an infection rate of 96% was attained. For long-term antibiotic treatment, a port system was developed and implanted. Hyperbaric treatment alone reduced the colony-forming units (CFU) from 2.9 x 10(6) to 6.2 x 10(5) x g(-1) of tibial bone. The effect on the infection was more pronounced with antibiotic therapy alone, 10.5 x 10(4) CFU per g of tibial bone were measured. However, changes were most marked using a 4-wk combination therapy consisting of HBO2 and an antibiotic agent. The colony count was 2.7 x 10(3) CFU. Each of the treatment modalities resulted in a significant therapeutic effect. The results not only demonstrated the effectiveness of HBO2 in the treatment of osteomyelitis, but revealed a potential additive effect with the combination of HBO2 and an antibiotic.

Animals↗
PubMed1990

[Insulinoma. Results of surgical treatment].

The insulinoma is the most common pancreas tumour with endocrine activity, with more than 2,000 cases being described in the literature worldwide. The first successful extirpation was performed by Graham in 1928. Clinical appearance is characterized by severe paroxysmal hypoglycaemia together with inadequately increased serum insulin levels. Surgery is indicated in such situations because of limited effectiveness of medicamentous therapy. Surgical approach and long-time results are discussed in this paper, with reference being made to 13 cases of the authors.

Adenoma, Islet Cell↗
PubMed1989

[Gambee single modified all-layer suture].

Our modified all-layer suture technique allows surgery of colon and rectum with a low rate of anastomotic leaks (2%). In experimental animal research on pigs we compared the modified all-layer suture with the Gambee and the stapling technique. The circulation was examined by radioactive marked microspheres, by microangiograms and by special injection preparations.

Anastomosis, Surgical↗
PubMed1988

[Computer-assisted analysis of intestinal sounds for assessing the motility of the gastrointestinal tract].

Intestinal noise analysis by means of a computerized analyser is a method by which various functional states of the gastro-intestinal tract can be diagnosed. Interference noise from respiration and cardiac action can be suppressed by filtering. Frequency patterns determined were in good correlation with the clinical picture and auscultation findings. It is, basically, possible to identify the original causative organ.

Auscultation↗
PubMed1986

[Therapeutic possibilities in adhesions].

Laparotomy was performed on 36 patients with persistent "adhesion complaints". Good therapeutic success was obtained from detachment of omental adhesions on the abdominal wall and of omental cords from the minor pelvis as well as from adhesiolysis in the hypogastric region. No peritoneal adhesions at all were recorded from nine patients, although they had undergone several operations before. Complaints were removed from one third of all patients, while nearly 20 per cent were improved. One death occurred, following exploratory laparotomy, due to stress-induced ulcer perforation. No peritoneal adhesion had been present in that case. No complications at all were experienced with any of the other patients.

Abdomen↗
PubMed1980

[Aneurysm of the ductus arteriosus in a newborn infant (author's transl)].

A large congenital aneurysm of the ductus arteriosus confirmed by cardiac catheterisation was operated in a nine day old infant. Prompt surgical intervention accounted for the patient's survival. Differential diagnosis of an intrathoracic mass should include a congenital ductus arteriosus aneurysm.

Aneurysm↗
PubMed1975

Implanted amniotic membrane as an autograft and as an allograft.

Detailed studies on autograft and allograft amniotic membranes implanted in the subcutaneous tissues to form tunnels are described. Autograft amniotic membranes appear to become permanent structures whereas allografts of this material, though accepted by the host for a longer time than most allografts, were eventually rejected. Serial histological studies were performed.

Amnion↗
PubMed1975

Wound healing and the amniotic membrane.

The successful clinical application of the amniotic membrane as a surgical dressing is discussed as to the mode of healing. The amniotic membrane does not appear to be a permanent structure when used as an allograft.

Amnion↗
PubMedDate not supplied

Effect of food-deprivation on rat pancreatic islet cells.

Somatostatin, insulin and glucagon concentrations in rat pancreas were measured following various intervals of food-deprivation. Tissue concentrations, as measured by radioimmunoassay, were correlated with A-, B-, and D-cell number and size using a scanning integrating image analyzer (Quantimet 720). Alterations in total islet hormone content were not correlated to changes in size or distribution of cells. This implies that changes in tissue content reflect changes in turnover of peptides rather than changes in cell size or number.

Animals↗