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Biomedical subjects

V Mayer

Publications and source records attributed to V Mayer.

133 records · Page 8Linked to original sources
PubMedDate not supplied

Studies of the sensitivity and reproducibility of commercial kits to detect antibodies to the human immunodeficiency virus.

Nine serial three-fold dilutions (1:1 to 1:6561) were prepared from 18 sera obtained from hemophiliacs confirmed to have antibodies to the human immunodeficiency virus. The dilutions were tested with five different commercial enzyme immunoassay kits and twelve sera were retested 5 to 7 months later by different lots of three kits. The dilution that gave an absorbance (OD) equal to the cut-off OD was considered as the titer of antibody. Sensitivities of the kits were compared by statistical and regression analysis; the same approach was used for studying reproducibility from the results of retesting. The highest titers were found with the Wellcome kit, the lowest with Organon and Pasteur kits, whereas intermediate values were found with the Sorin/Biomedica and Electronucleonics kits. With the Organon and Wellcome kits, excellent reproducibility was observed on later retesting; however, a significant change in titers was seen on retesting the Sorin kit.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Barber-Johnson analysis of bed utilization in hospital-based health care in the Croatian Republic during peace and war:1986-1991].

Intensity of bed utilization in Croatia's hospitals in the peace-time period 1986-90 and the war year of 1991 was evaluated. The study covered 32 general-and-teaching hospitals disposing with 21,300 beds in 1986-90 and 27 of these hospitals with 19.000 beds in 1991. Basic information derives from hospital's statistical reports analyses by the Barber-Johnson's technique. While length of stay was reduced in the 1986-90 period, average number of discharges and deaths per available beds increased (1986/26.1; 1990/26.9). In the peace year of 1990 the performances of 11 of the 32 hospitals grouped in a zone limited to 10.0-12.9 days for the length of stays and 1.1-2.5 days for turnover interval. In the war year of 1991 the performances of 10 of the 27 hospitals were grouped in a zone defined by 8.5-10.9 days for length of stay and by 3.1 and 6.2 days for turnover interval. The Barber-Johnson's analysis provides key information in the decision making about hospital beds utilization, as well as in the evaluation of such decisions.

Bed Occupancy↗
PubMedDate not supplied

Plasma levels of the anti-HIV drug 3'-azido-2',3'-dideoxythymidine (AZT): determination by RIA and HPLC.

The radioimmunoassay (RIA) with two commercial kits and the high pressure liquid chromatography (HPLC) method were employed to test human and dog blood plasma levels of AZT following oral and intravenous administration of AZT preparations Retrovir and Azitidin. A comparison of results obtained by the two RIA kits showed a good correlation. A weaker correlation was established in comparing the results obtained by RIA with those obtained by HPLC. Because of its reliability, rapid availability of results and the price, RIA is more advantageous than HPLC for routine use in monitoring the therapy as well as in determining pharmacokinetic parameters of AZT.

Administration, Oral↗
PubMedDate not supplied

[Analysis of hospital mortality in the Croatian Republic using selected indicators].

Mortality trends and distribution in a system of 32 general and teaching hospitals in the Republic of Croatia for the years 1966 through 1989, separately for 1986/1987, were evaluated as a possible informational support to the national policies regarding developing of health care system. By means of 13 elaborated and/or selected indicators, using hospital health statistics as a data base, we measured the changes in the dynamics, structure and level of death at institutions, individual medical departments and among patients. Hospitals mortality statistics was found to offer a good informational orientation for monitoring realization of the hospital's restructuring activities envisaged under the Aim 29 of the Croatian strategy Health for All by the Year 2000 as well as for planning technical surveillance and streamlining the special statistical studies on inpatient health care. It can also provide a solid base for the evaluation of the quality of inpatient medical care, if the diagnosis of causes of death is improved, methodology for sentinel-health-events adopted, commissions for the evaluation of inpatient health care organized, medical registration units established and the National Register of Autopsy begun.

Adult↗
PubMedDate not supplied

[Adrenogenital syndrome in an adolescent].

A case is presented of primary amenorrhea resulting from the hyperfunction of the adrenal cortex. The condition developed in prepuberty. The mode of the establishment of the diagnosis and the effect of dexamethason treatment are discussed.

Adolescent↗