Biomedical subjects

V M Saf'janova

Publications and source records attributed to V M Saf'janova.

4 recordsLinked to original sources

PubMed1991

Phlebotominae sandflies as the key link of Leishmania parasitic systems.

Interrelations of Leishmania with their invertebrate hosts-sandflies are sufficiently specific. Among the factors determining the specificity of Leishmania-Phlebotominae species to species relations the peritrophic membrane is one of the most important. It has various structural and functional pecularities in representatives of different Phlebotominae species, which determine the character of the Leishmania life cycle within sandflies. The spatial and temporal existence of leishmaniases foci as well as their epidemiological manifestation are conditioned by both the adaptation of sandfly species-the invertebrate hosts of the parasites to certain landscapes and their connection with certain species of vertebrate hosts as a source of bloodfeeding. Thus Phlebotominae sandflies play the part of the key link of the Leishmania parasitic systems.

Animals↗

PubMed1973

Use of ferritin-labelled antibodies for differentiating Leishmania species and other Trypanosomatidae.

A new immunomorphological test for differentiating Leishmania species, based on electron-microscopic revelation of the localization of their specific antigens, is described. The diagnostic value of treating the promastigotes of Leishmania and other Trypanosomatidae with ferritin-labelled antibodies was determined in cross experiments. The immunoferritin test reveals both the serogroup of a given species of Leishmania and specific antigenic differences between different species. However, it fails to differentiate different strains of a given species of Leishmania, which attests to its species-specificity.

Animals↗

PubMed1973

Comparative study of biological characteristics of the causal agents of zoonotic and anthroponotic cutaneous leishmaniasis in the USSR.

A comparative study was made of the virulence of Leishmania tropica major and L. tropica minor, the causal agents of the zoonotic and anthroponotic forms of cutaneous leishmaniasis, from the USSR and their antigenic characteristics were compared with those of other Leishmania species (L. donovani, L. adleri, and promastigotes from Turkmenian reptiles). The virulence of strains of L. t. major was slightly higher than that of strains of L. t. minor. However, the difference in virulence gradually levelled out in successive multiple passages of the strains in hamsters. A comparative serological study of L. t. major and L. t. minor revealed clear antigenic differences between them. The differences between L. t. major, L. t. minor and L. donovani were shown to be equal in degree.

Animals↗

PubMed1971

Leishmaniasis control.

The article sets forth the basic principles for the control of the leishmaniases, which are for the most part diseases occurring in natural foci. The need for specially planned measures for leishmaniasis control is emphasized. Different measures are required in different regions according to the type of epidemic focus and the nature of the disease cycle.In view of the specificity of the biological interrelationships between leishmaniae and their invertebrate hosts, sandfly control is of paramount importance in the prophylaxis of the leishmaniases.In the USSR, it has been possible to clear completely foci of anthroponotic cutaneous leishmaniasis by the implementation of a series of special measures including measures to eradicate the causal agent (treatment of patients) and the vector of the infection.

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