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Biomedical subjects

V M Mahajan

Publications and source records attributed to V M Mahajan.

At least 37 records · Page 2Linked to original sources
PubMed1982

Toxigenic strains of Staphylococcus epidermidis and their experimental corneal pathogenicity in rabbits.

Thirty strains of Staphylococcus epidermidis, ten each from normal conjunctival sacs, corneal ulcer cases and from those who developed postoperative endophthalmitis, were examined for their dermonecrotic and haemolytic activities. Dermonecrosis was studied on rabbit skin whereas haemolysis was determined against sheep, guinea pig, rabbit and human erythrocytes. None of the cell free filtrates from strains derived from normal sacs showed any evidence of toxin production. Four strains from corneal ulcer cases and five from postoperative infections produced + to + + + dermonecrosis whereas haemolytic activity was exhibited by one strain in the former and by two in the latter. Only those strains that were highly dermonecrotoxic were haemolytic. Experimental corneal lesions in the rabbit were mild by strains from normal sacs. Those showing highest dermonecrotoxic reaction, irrespective of their source, produced identical and most severe corneal pathology when compared to those producing minimal necrosis.

Animals↗
PubMed1982

Pseudomonas aeruginosa: isolation from ocular tissues. Aeruginocin typing and its relationship to corneal pathogenicity in rabbits.

Fifty strains of Pseudomonas aeruginosa isolated from human eyes were aeruginocin typed by the method of Shriniwas (1974) using ten indicator strains. These belonged to types A1 (3), B (2), F1 (1) and 14 (1). Fifteen (30%) were nontypable and 28 (56.0%) were unclassifiable presenting twenty inhibition patterns. The strains showed a wide range of antibiotic sensitivities. The highest number of insensitive strains were those obtained from corneal ulcers. Experimental keratitis produced by strains of pseudomonas was either mild, moderate or severe and was unrelated to their source. Mild keratitis was produced by types UC 7-, UC 79- and 14 isolated from pre-operative, corneal ulcer and post-operative patients. Lesions of moderate severity were produced by types 189+ & A1 whereas the severest pathology was produced by UC 23478-, B and UC 810- types. The fact that strain 23478- always produced severest pathology irrespective of whether originated from group I, II, or IV strongly suggests relationship of pathogenicity with aeruginocin type.

Animals↗
PubMed1982

Antimycotic activity of berberine sulphate: an alkaloid from an Indian medicinal herb.

Berberine sulphate in concentrations of 10-25 mg ml -1 inhibited the growth of 11/13 fungi, viz. Alternaria, Aspergillus flavus, Asp. fumigatus, Candida albicans, Curvularia, Drechslera, Fusarium, Mucor, Penicillium, Rhizopus oryzae and Scopulariopsis. Concentrations of 50 mg ml -1 could check the growth of Syncephalastrum as well but Asp. niger remained unaffected.

Alternaria↗
PubMed1981

Comparison of enzyme-linked immunosorbent assay and haemagglutination inhibition test for the detection of Newcastle disease virus antibodies in human sera.

A comparison of haemagglutination inhibition (HI) and enzyme-linked immunosorbent assay (ELISA) techniques for the detection of antibodies against Newcastle disease virus in sera from persons working in poultry farms and veterinary vaccine institutes and from the general population revealed that 22% more sera were positive by ELISA compared to HI. No samples were negative by ELISA but positive by HI. While HI titres of positive sera were found in the range 8-64, ELISA titres were between 16 and 512. It was interesting that though 78% sera had concordant results by the two tests, titres obtained by ELISA were nearly six times higher than those by HI.

Animals↗