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Biomedical subjects

V M Kazakov

Publications and source records attributed to V M Kazakov.

36 records · Page 2Linked to original sources
PubMed1981

[Neurologic pathology in butterfly deformities of the body of the mid-thoracic vertebra (clinico-x-ray-anatomic observation)].

Results of the clinico-roentgenological observation of butterfly-like deformity of the middle dorsal vertebra body (a rare congenital anomaly) are presented. In the presence of an infection the patient developed a spinal pathology (lower central paraparesis, parahypesthesia, disturbances of the functions of pelvic organs). The neurological symptoms were found to be due to an adhesive process in the spinal meninges at the level of the deformed vertebra and the secondary compression-ischemic myelopathy. The treatment consisted in injecting prednisolone under the spinal meninges. The patient's roentgenograms were compared with a macerated museum preparation of dorsal vertebrae.

Adult↗
PubMed1978

[Myopathy (terminology, clinical picture, and diagnosis)].

The paper deals with a description of the clinical picture and diagnosis of the main types of myodystrophies taking into account formes of muscular damages and a trend of generalization of a pathological process at the early phase of the disease. The clinical picture of endocrine myopathies was also studied. The authors revealed almost the same formula of muscular damages. Muscles of the pelvic girdle and femurs mainly suffered and to a lesser degree--muscles of the shoulder girdle and shoulders. According to the data of the clinical picture, histopathology and electromyography endocrinic myopathies are phenocopies of hereditary myodystrophies.

Adolescent↗
PubMed1978

[Endocrine myopathies. Muscular lesions in thyrotoxicosis].

The authors studied 42 patients with endocrine myopathy. In thyrotoxic myopathy prevalent muscle lesions of the pelvic girdle and femur were found. EMG studies (with the aid of point electrodes), histological and histochemical studies of the muscles in patients with thyrotoxicosis indicate a primary muscular character of the atrophies. The report contains descriptions of pathomorphological and histochemical changes in the muscles in experimental thyrotoxic myopathy.

Adult↗
PubMed1977

Chronic spinal muscular atrophy simulating facioscapulohumeral type and limb-girdle type of muscular dystrophy. Report of two cases.

Two cases of chronic spinal muscular atrophy simulating the clinical picture of the facioscapulohumeral type and limb-girdle type of muscular dystrophy are reported. Both patients had a waddling gait, Gowers' maneuver in arising, terminal atrophies and pseudohypertrophies of some muscles, marked fasciculations, and fascicular tremor. The electromyogram revealed signs of anterior horn cell disease. Calf muscle biopsy (case 2) revealed 'myopathic' changes.

Chronic Disease↗
PubMed1976

The myogenic scapulo-peroneal syndrome. Muscular dystrophy in the K. kindred: clinical study and genetics.

Additional study was carried out of six generations belonging to the K. kindred, which were previously investigated by Oransky (1927). Eighteen members of this kindred were studied. In the early stages of the disease a sharp dissimilarity was observed in the phenotypes in the K. kindred, resulting from different rates of development and varying intensity in the course of the disease, so that it ranges from evident scapulo-peroneal amyotrophy to cases resembling Landouzy-Déjerine muscular dystrophy. In the later stages of the disease the clinical data on those affected were noted to be very similar. Muscular dystrophy in the K. kindred has been inherited as an autosomal-dominant type for five generations. The penetrance of the gene is almost complete. The expressivity of the gene varies from abortive to severe forms of disease. From the clinical and genetic data available at the present time, is seems that the muscular dystrophy in the K. kindred is one of the varieties (namely, a descending type with a "jump") of the facio-scapulo-limb (or facioscapulohumeral) muscular dystrophy. The scapulo-peroneal syndrome could be a long stage in the development of the disorder in some members of the K. kindred. As well as muscular dystrophy, some muscle anomalies have been independently inherited in the K. kindred. Apparently, muscular dystrophy and muscle defects are caused by the non-allele genes; this ensures the independent distribution of these signs among the members of the K. kindred.

Adolescent↗
PubMed1976

[Clinico-genetic classification of muscular dystrophy].

The authors have given a critical review of existing classifications of myodystrophies from 1884 till 1973. They propose a new systematization based on the formula of muscular lesions during different phases of the disease and on the formula of a generalization of the myodystrophical process. It is assumed that the formula of muscular atrophies and the direction of the generalization of the myodystrophical process is genetically conditioned and should be considered as an important sign of hereditary neuro-muscular diseases. The authors believe that the facio-scapulo-limb type of myodystrophy both clinically and genetically is not homogenous. This form of dystrophy should be divided into 2 variants: a gradually descending one and a descending one with a "jumping" of muscular atrophies from the upper half of the body (face, shoulder) to the peroneal group of muscles on the skin.

History, 19th Century↗
PubMed1975

Myogenic scapuloperoneal syndrome - muscular dystrophy in the K. kindred. Reexamination of the K. family described for the first time by Oransky in 1927.

Additional study of six generations belonging to the K. kindred, which were previously investigated by Oransky in 1927 was carried out. 18 members of this kindred were studied. At the early stages of the disease a sharp dissimilarity of the phenotypes in the K. kindred resulting from the different rate of the development and intensity in the course of the disease was observed, varying from evident scapuloperoneal amyotrophy to the cases resembling Landouzy-Déjerine muscular dystrophy. At the late stages of the disease a considerable clinical simularity of those affected was noted. The clinical and genetic data allowed at the present time to consider the muscular dystrophy in the K. kindred as one of the varieties (namely, as a descending type with a "jump") of the facio-scapulo-limb (or facioscapulohumeral) muscular dystrophy. The scapuloperoneal syndrome could be a long stage in the development of the disorder in some members of the K. kindred.

Adolescent↗
PubMedDate not supplied

[Dynamic interphasic tensiometry of the blood in chronic hepatitis and liver cirrhosis].

Studied with the aid of the computerized tensiometer MPT2-Lauda (Germany) was dynamic surface tension (ST) of blood serum in patients with chronic hepatitis (ChH), hepatic cirrhosis (HC), and in essentially healthy people, with n = 44, 32, and 68 respectively. ChH was shown to be accompanied by a significant increase in ST indices in the region of short (t = 0.01 sec) times of the surface life as well as by a decrease in that of medium (t = 1 sec) and long (t-->infinity) times. Rise in parameters of interphase tensiograms is a prognosis-negative sign with respect to the development of HC. Correlations have been established of indices of blood ST to its content of protein, lipid, and inorganic substances and to morphological signs of affection of the liver as well.

Adolescent↗
PubMedDate not supplied

[The possible role of disruptions of the cyclic AMP system in the pathogenesis of thyrotoxic myopathies].

The value of kdiss of the "proteinkinase-cAMP" complex was increased 1.8-fold, number of the nucleotide binding sites was increased 3.7-fold with simultaneous decrease in cAMP concentration, when the cyclase system was studied in skeletal muscles of mice with experimental thyrotoxic myopathy. Activities of phosphodiesterase, adenylate cyclase, rate of activation of adenylate cyclase by adrenaline and sodium fluoride did not significantly differ as compared with normal values. Impairment of hormonal regulation of the cAMP-dependent processes is apparently responsible for multiple molecular and structural injuries in skeletal muscles in thyrotoxicosis.

3',5'-Cyclic-AMP Phosphodiesterases↗