Age dynamics of regulation in the adaptation homeostat and age pathology.
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11-Hydroxycorticosteroids↗
Biomedical subjects
V M Dil'man
Publications and source records attributed to V M Dil'man.
[Effect of succinic and glutamic acids on the sensitivity of the hypothalamo-gonadotropic system to inhibitory effect of estrogens in old rats].
The daily s. c. injections of 0.58 gamma of stilbestrol to young hemicastrated rats suppressed compensatory hypertrophy (COH), but did not influence COH in old rats. Administration of succinate (i. p. per os or into the 3d brain ventricle) or of glutamate (per os) to old rats restored estogen suppression of COH.
Aging↗
[The effect of pharmacological preparations on the regulation of growth hormone secretion].
The authors have assessed the effects of 7 metabolic and 5 neutral drugs and their combinations on the basal blood concentration of the growth hormone (GH) and on the sensitivity of GH-regulating centers to homeostatic glucose inhibition. No significant changes in GH basal level were revealed. Nacom and a combination of vitamins E and C reduced the threshold sensitivity to glucose inhibition of the GH, whereas miscleron and trental elevated this threshold sensitivity. A combination of butamid and nacom had the highest stimulatory effect on the cellular immunity and macrophagal function, that may be mediated by enhanced GH secretion. In subjects with the 'superior' (android) type of obesity GH basal concentration and its sensitivity to glucose inhibition were lower than in those with the 'inferior' (gynoid) type, this being true after the drug discontinuation.
Breast Neoplasms↗