Search PubMed⌕ Search

Biomedical subjects

V M Buckalew

Publications and source records attributed to V M Buckalew.

92 records · Page 6Linked to original sources
PubMedDate not supplied

Candidate gene analysis in African Americans with renal failure.

A search for renal failure genes is being conducted in African American sib pairs concordant for end-stage renal disease (ESRD) recruited predominantly from the dialysis population in the Southeastern United States. Family history data is being collected in patients from more than 250 individual dialysis units. Patients with polycystic kidney disease, Alport's Syndrome and confirmed urologic disease are excluded. The study employs a candidate gene strategy initially, followed by a genome-wide search for linkage between polymorphic markers and the phenotype "ESRD."

Black People↗
PubMedDate not supplied

Summary of a symposium on natriuretic and digitalis-like factors.

An international symposium on natriuretic and digitalis-like factors was convened for the first time since 1992. Topics discussed included structures and biosynthesis of endogenous digitalis-like factors (EDLF), biologic activities, physiology function and role of EDLF in hypertension, and novel natriuretic factors. Progress was reported in determining the exact structure of an isomer of ouabain isolated from bovine hypothalamus. Evidence was presented supporting the existence of a second mammalian EDLF that resembles steroids found in toads (bufodienolides). Support for endogenous synthesis of mammalian EDLF was also presented. Mammalian EDLF were reported to have effects which are different from those possessed by digitalis like steroids derived from plants. New evidence was presented implicating EDLF in various forms of hypertension in humans and animal models. Finally, several unique natriuretic factors that do not inhibit Na, K ATPase and that appear to play a role in mammalian volume regulation were discussed.

Animals↗