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Biomedical subjects

V M Andrianov

Publications and source records attributed to V M Andrianov.

25 records · Page 2Linked to original sources
PubMedDate not supplied

[Study of the ultrastructural and functional expression of the hepatocyte genome under conditions of prolonged depression of protein biosynthesis by cycloheximide. III].

Dynamics of changes in mtRNA synthesis and mitochondria ultrastructure is strictly dependent on the level of inhibition of biosynthesis of cytoplasm proteins and "soluble" proteins of mitochondria by cycloheximide in hepatocytes: 1-6 hrs later a progressive weakening of protein synthesis is accompanied by a drop in mtRNA synthesis and essential destruction of mitochondria; from 12 to 24 hrs a partial restoration of protein biosynthesis induces the processes of the above-mentioned indexes normalization.

Animals↗
PubMedDate not supplied

[Electron microscopic and electron radioautographic study of cells in glandular hyperplasia and cancer of the endometrium].

Peculiarities of the ultrastructure and RNA synthesis in the epithelial endometrial cells of nine patients with hyperplasia and the uterine cavity cancer have been studied by the electron-radioautographic method. Quantitative differences are revealed in the ultrastructures of the cells. Amplification of the nucleoli labelling and asynchronism of the RNA synthesis in the nucleoli with glandular hyperplasia and endometrial cancer are observed.

Adenocarcinoma↗
PubMedDate not supplied

[Ultrastructural changes in hepatocyte nuclei reflecting genome expression and nuclear RNA biosynthesis in the early premitotic period of rat liver regeneration].

Modifications of the nucleus ultrastructure and specific radioactivity of nuclear and cytoplasmic RNA from hepatocytes were studied at early stages of liver regeneration using 14C-orotic acid as a labelled precursor. It is shown that the first three hours after partial hepatectomy are characterized by mobilization of inherent abilities of the nucleus and initiation of chromatin activation. Then three hours after operation the activity of nucleolar and extranucleolar apparatus increases. By 12 hours chromatin associates with a nuclear membrane for preparing DNA replication.

Animals↗