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Biomedical subjects

V M Anderson

Publications and source records attributed to V M Anderson.

33 records · Page 2Linked to original sources
PubMed1982

Spontaneous improvement of Pneumocystis carinii pneumonia in childhood acute lymphocytic leukemia.

Until recently, Pneumocystis carinii pneumonitis was the most common cause of death in patients with leukemia in remission. Prior to the advent of effective antimicrobial agents, this disease was virtually 100% fatal in the cancer patient undergoing immunosuppressive therapy. The spontaneous improvement of P carinii pneumonitis in a child with acute lymphocytic leukemia suggests a higher incidence of P carinii pneumonitis in immunocompromised patients than is commonly realized.

Biopsy↗
PubMed1982

Pulmonary lymphatic air: locating "pulmonary interstitial emphysema" of the premature infant.

Pulmonary interstitial air in the premature infant, a complication of hyaline membrane disease and respiratory supportive treatment, is usually described as representing freely dissecting air that has escaped from terminal air spaces to dissect along the bronchovascular bundles of the lung. By inflating the lung and fixing it in this state, the interstitial air is identified within the lymphatics of the interlobular septae and visceral pleura. On a radiography, this lymphatic air is seen as a pattern of fine linear lucencies involving a lobe or an entire lung. With increasing distension, oval and cystic lucencies are seen representing air in dilated septal lymphatics and lymphatics of the visceral pleura. Pneumothorax results from rupture of these collections into the pleural space.

Female↗
PubMed1982

A case of pulmonary veno-occlusive disease in infancy.

A 1-year-old girl who had failure to thrive died suddenly of pulmonary veno-occlusive disease. In this case, the vascular disorder was due to nonthrombotic obstruction of only the postcapillary venules. This unusual pattern of involvement and the absence of thrombi, new or old, suggests that the pathogenesis of pulmonary veno-occlusive disease may involve mechanisms other than thrombosis.

Capillaries↗
PubMed1981

Cephalothoracopagus janiceps malformation. A contribution to the pathogenesis of cerebral malformation.

We report the first histologic findings of the CNS in cephalothoracopagus janiceps monosymmetros. The findings are compared with the other ten reported cases of this type of conjoined twin. The faces and CNSs showed asymmetry of development manifested chiefly in the prosencephalon, specifically the cortical gyri, corpus callosum, and subependymal mantle layer. It is difficult to explain discordance for congenital malformations in monovular or conjoined twins by either genetic or environmental mechanisms. It appears related to the vascular supply of the brain and a state of chronic ischemia rather than to a discrete insult and developmental arrest at a specific time during embryogenesis.

Abnormalities, Multiple↗
PubMed1979

Giant condyloma acuminatum of the endocervix and lower uterine segment.

A 34-year-old woman presented with lower abdominal pain, dysmenorrhea, dyspareunia and vaginal discharge. A total abdominal hysterectomy was done for persistent, severe uterine pain unresponsive to medical management. Histologic examination of the surgical specimen revealed a large condyloma acuminatum of the endocervix and lower uterine segment. This represents a rare manifestation of a very common venereal disease.

Adult↗
PubMedDate not supplied

Coarctation of the left pulmonary artery: effects on the pulmonary vasculature of infants.

At autopsy, two infants had unsuspected coarctation of the left pulmonary artery (CoLPA), which was produced by an extension of ductal tissue into the wall of the left pulmonary artery. The first case, a 4-month-old girl, also had a ventricular septal defect and an anomalous branching pattern of the innominate arterial trunk. Pulmonary arterial hypertensive changes were noted in the right lung. In contrast, the left lung showed thin-walled pulmonary arteries. The second case, a term female newborn, had exhibited severe unexplained respiratory distress since birth. Histologic sections of the right lung showed dilated pulmonary arteries with thinned media, whereas the left lung showed a persistent fetal arterial pattern. It is believed that the peripheral pulmonary arterial changes are age-dependent and associated with asymmetric blood flow between the right and left pulmonary arteries. CoLPA is a rare pulmonary artery defect, and early diagnosis of this abnormality is important.

Constriction, Pathologic↗
PubMedDate not supplied

Histopathology of childhood pneumonia in developing countries.

Acute lower respiratory infection in children is a major cause of morbidity and mortality in developing countries. Viral and bacterial agents incite characteristic host responses at the level of the bronchi, bronchioles, alveolar walls, and air spaces that correlate with the clinical course. A systematic review of histopathologic features will enhance the understanding of the pathogenetic mechanisms and cofactors that influence the disease process, particularly how tissue injury may be influenced by nutritional status and access to antibiotics. Research priorities include immunologic assessment, micronutrient assays, and standardized autopsies in developing countries. DNA probes for organisms and immunocytochemical identification of cell markers in tissue promise a new era in microscopic visualization of pathogen-host interactions. International collaborative research between ministries of public health and medical universities must be encouraged as a means of providing technical assistance and of advancing new knowledge. Systematic standardized autopsy studies from multiple geographic areas may help define pathologic mechanisms, monitor the natural history of disease, and evaluate interventions in diverse populations.

Acute Disease↗