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Biomedical subjects

V Lyall

Publications and source records attributed to V Lyall.

26 records · Page 2Linked to original sources
PubMed1982

Effect of chronic cadmium treatment on the ascorbic acid status of the rat.

In rats chronically treated with varying doses of cadmium (Cd) (0.25, 0.50, 0.75 and 1.0 mg/kg body wt.), i.p., every alternate day for 7 weeks, a decrease in the ascorbic acid (AA) content of adrenals and liver was observed. In the adrenals AA depletion was significant and dose-dependent at all concentrations. In liver the decrease was significant only at a concentration of 0.75 and 1.00 mg/kg but the spleen did not show any change in AA content. Urinary excretion of beta2-microglobulin with increasing doses of Cd indicated progressive renal tubular damage. The decrease in tissue AA status was correlated with the severity of the renal tubular damage resulting in an inhibition of its reabsorption from the kidneys.

Adrenal Glands↗
PubMed1982

Effect of vitamin B6 and B1 deficiencies on the intestinal uptake of calcium, zinc and cadmium.

A chronic vitamin B6 deficiency in rats resulted in a non-specific increase (44- 51%) in the in vitro intestinal uptake of both essential (Ca and Zn) and non-essential toxic metal (Cd) ions, whereas an acute B6-deficient state only affected the Zn uptake rate. In vitamin B1-deficient animals, a specific decrease (30-32%) was observed in Ca and Zn uptake with a 59% increase in the intestinal uptake of Cd. These altered metal ion uptake rates were probably not a result of hormonal disturbances due to the vitamin-deficient states.

Animals↗
PubMed1979

Effect of chronic hypo and hypervitaminosis C on the brush border enzymes and the intestinal uptake of glucose and alanine.

Brush border sucrase and alkaline phosphatase activities are considerably enhanced in the intestine of ascorbic acid deficient guinea-pigs. Similar increase in the uptake of D-glucose and L-alanine also occurs in chronic vitamin C deficiency. However the permeability of D-glucose and L-alanine in the intestine of animals fed with large doses of vitamin C is severely depressed, with a reduction in the levels of sucrase and alkaline phosphatase activities.

Alanine↗