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Biomedical subjects

V Legrand

Publications and source records attributed to V Legrand.

96 records · Page 6Linked to original sources
PubMed1980

[Hemodynamic complication of ventricular stimulation in a patient with moderate aortic stenosis].

This report is concerned with a patient aged 76 with mild to moderate aortic stenosis and transient A-V block who was treated by stand-by intracardiac pacing. In spite of this, the patient continued to present syncopal attacks. It is demonstrated that these episodes were related to dramatic decreases of systolic blood pressure and cardiac output occurring whenever the right ventricle was paced. These hemodynamic alterations were secondary to the loss of atrial contribution to ventricular filling. They were suppressed by insertion of a sequential auriculoventricular pacemaker.

Aged↗
PubMedDate not supplied

Characterization of changes in coronary blood flow during the first six seconds after intracoronary contrast injection.

With current interest in digital and densitometric angiographic techniques for evaluating coronary blood flow (CBF), the immediate effects of intracoronary contrast injections on CBF are important to establish. We investigated the effects of ECG-gated intracoronary injection of contrast on CBF with different injection rates (1-6 cc/sec), volumes (1/2-6 cc), and contrast concentrations (1/2, full strength). Sixteen open-chest dogs were instrumented with electromagnetic flow probes on the left anterior descending artery. During intracoronary injections of contrast, a characteristic decrease in coronary blood flow to approximately 45% of preinjection levels was seen an average of 1.9 seconds after intracoronary contrast injection. The timing of the depression in coronary flow was most influenced by the rate of contrast injection, and the magnitude of depression in flow was influenced by both the volume and concentration of the contrast injection. Angiographic techniques using the first 6 seconds after injection to obtain CBF measurements should take these characteristic changes into account to avoid possible errors.

Angiography↗
PubMedDate not supplied

[Coronary artery disease associated to diabetes mellitus].

Diabetes mellitus represents a major coronary risk factor. Diabetes promotes atherosclerotic plaque development through different mechanisms among which oxidative stress induced by hyperglycaemia appears to play a major role. Knowledge of pathophysiologic mechanisms associated with diabetes helps to better understand the rationale for treatment. Besides a tight control of all cardiovascular risk factors, prescription of drugs aiming of stabilization or even reduction of atherosclerosis should be systematically recommended. These drugs include statines, ACE inhibitors and aspirin eventually combined with clopidogrel. The use of beta blockers should be encouraged in case of stable angina. Finally, any patient with symptomatic modification suggesting acute coronary syndrome should be considered for myocardial revascularization.

Angiotensin-Converting Enzyme Inhibitors↗