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Biomedical subjects

V L Ganul

Publications and source records attributed to V L Ganul.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Relation of spontaneous chemiluminescence, electrochemiluminescence and resistance of blood serum in patients with cancer of the proximal part of the stomach and esophagus].

The levels of spontaneous chemoluminescence of serum in patients with cancer of the proximal part of the stomach and the esophagus were found to be 2-6 times the age-connected norm. The said concentrations decreased by half following radiation treatment, to rise by 75% after surgery. At later periods after surgery, chemoluminescence levels dropped almost to normal unless complications developed. However, in patients with gastroesophageal cancer, the level of spontaneous chemoluminescence remained high over a long period of time. Variation patterns were identical, with an amplitude being significantly lower. Changes in blood serum resistance were insignificant. Scale factor K varied in the range of 6-66. In cases of purulent complications, spontaneous chemoluminescence levels showed a sharp rise, the values of K exceeding 75. This pattern made it easier to differentiate between inflammatory lesions and neoplasia.

Blood Physiological Phenomena↗
PubMed1984

[The pituitary-adrenal system in cancer of the esophagus and stomach].

Excretion of corticosteroids, levels of 11-OCS in blood plasma, tests with dexasone and clinical evaluation of the pituitary-adrenal system function were studied in 354 patients with carcinomas of the esophagus and proximal stomach division. Some degree of hypocorticism with a decrease in the 11-OCS level in blood plasma and lowered excretion of corticosteroids in the urine were found in 71% of patients. These variations are accompanied by lowered hypothalamus sensitivity to dexasone. Similar disturbances though less pronounced are determined in the precancerous states and in the remote periods after operation.

17-Hydroxycorticosteroids↗
PubMed1983

[Correction of hypophyseal-adrenal system function in esophageal and stomach cancer patients undergoing combined and surgical treatments].

The paper presents the data on marked dysfunction of hypothalamo-pituitary-adrenal system in patients with esophageal and gastric cancer. Patients revealed lowered levels of 11-hydroxycorticosteroids in blood plasma and 17-corticosteroids and 17-glucocorticosteroids in diurnal urine. It was matched by an elevated threshold of hypothalamic sensitivity to inhibition by glucocorticosteroids. Treatment for these disturbances which brought the function of this system to normal had a beneficial effect on the secretion and excretion of corticosteroids in the course of combined therapy and surgery and was followed by a significant decrease in hemodynamic complication incidence. The favorable clinical effect was in correlation with the decrease in hypothalamic resistance to the inhibitory effect of glucocorticoids.

11-Hydroxycorticosteroids↗
PubMed1982

[Spontaneous blood serum chemiluminescence in detecting recurrences and metastases of cancer of the proximal portion of the stomach and esophagus].

The report deals with the results of examination of 48 healthy donors and 261 patients suffering from malignant tumors of cardia and esophagus, 84 patients after radical surgery included. Spontaneous chemoluminescence (CL) of blood serum was shown to depend on the general condition of the patient and tumor involvement before treatment: there is a direct correlation between these factors and luminescence intensity. Therefore, CL may be used as a laboratory test providing necessary information for developing treatment modality for each individual case. Within 0.5-60 months after radical treatment, the rise in the intensity of blood serum CL (60-100% and more) was registered in cases of pyo-inflammatory complications (peritonitis, mediastinitis, pleural empyema, etc.) and recurrence and metastatic spreading. A rise in CL intensity by more than 50% and a steady tendency to further increase may be interpreted as a pointer to recurrence or metastasis development.

Blood Physiological Phenomena↗
PubMed1980

[Spontaneous blood serum chemiluminescence in patients with cancer of the esophagus and proximal portion of the stomach].

Based on the maternal pertaining to 193 patients with cancer of the esophagus and proximal gastric portion, 22 patients with non-tumor diseases of the stomach and esophagus, 19 donors (aged 18-25 years) and 10 practically healthy subjects aged 34-67 years, it was found that tumor invasion of the stomach body and the presence of such aggravating factors as grade IV dysphagia, inflammatory complications etc. are associated with a significantly increased intensity of serum chemiluminescence. Anesthesia and other factors as a concomitant of surgery reduce considerably the level of blood serum chemiluminescence during the operation, whereas an intensive postoperative therapy retains its initial level. The development of complications during the operation and after it is accompanied with 1.5--2 times or more increased luminescence. Radical surgical and combined treatment would condition the normalization of the luminescence. Radiation treatment first increases and then decreases the luminescence down to normal values.

Adult↗
PubMed1980

[Microcirculation in cancer of the esophagus and cardial portion of the stomach under combined therapy].

Under study was the status of microcirculation in surgical and combination treatment (with radiotherapy) in patients with cancer of the esophagus and gastric cardia. The method of isotope semiresorption from the muscle depot (64) of patients and the arterio-venous difference for water after the technic of V. P, Kaznacheev and A. A. Dzizinski (26 patients) were employed. The state of microcirculation was found to be dependent on the degree of emaciation, preoperative telegamma therapy and the postoperative complications. The mostly impaired microcirculation was noted in emaciated patients with developing complication who were subjected to radiotherapy.

Adult↗