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Biomedical subjects

V L Cherkasov

Publications and source records attributed to V L Cherkasov.

At least 19 recordsLinked to original sources
PubMed1991

[The heparin and trental treatment of patients with the hemorrhagic form of erysipelas].

Activation of procoagulant hemostasis and signs of increased consumption of thrombocytes were indications for the treatment of patients with hemorrhagic erysipelas by means of heparine (60 patients) and trental (30 patients). Heparine was introduced subcutaneously as "minidoses" by means of electrophoresis into the inflammation focus. Heparine produced a positive effect on hemostasis and fibrinolysis, favoured rapid disappearance of the hemorrhagic syndrome, prevention of complications of erysipelas. Trental effected positively thrombocytic hemostasis, local manifestations of the hemorrhagic syndrome but did not prevent the development of thrombophlebitis as complication of the disease.

Adolescent↗
PubMed1990

[The treatment of patients with the hemorrhagic form of erysipelas by using amben and parmidine].

Amben (fibrinolysis inhibitor) and parmidin (bradykinin inhibitor) were used as pathogenetic treatment of 38 and 36 patients with hemorrhagic erysipelas respectively. Early amben treatment proved clinically rather effective and was accompanied by normalization of fibrinolysis and kallikrein-kinin system. Parmidin treatment resulted only in pain control, other subjective signs, normalization of the kallikrein-kinin system while fibrinolysis activity was maintained at former levels.

4-Aminobenzoic Acid↗
PubMed1989

[The immunopathological mechanisms of the skin lesion in erysipelas patients].

The localization of bound IgG, IgA, IgM and component C3 of the complement in the focus of skin lesion in patients with different forms of erysipelas has been studied by the method of direct immunofluorescence. The presence of fixed immune complexes and component C3 in the affected areas of the skin at the acute period of the disease and their absence in the healthy areas of the skin have been established, which seems to be indicative of the presence of the local immunocomplex process in erysipelas. This process is one of the mechanisms of erysipelatous inflammation.

Acute Disease↗
PubMed1988

[Diagnostic importance of various methods of determining infectious O-antigenemia in patients with typhoid and paratyphoid fevers A and B].

Altogether 181 patients with typhoid and paratyphoid fever (54 with typhoid fever, 50 with paratyphoid fever type A, and 77 with paratyphoid fever type B) were investigated. Of them 108 (59.7%) patients were examined during the 1st week of disease. Serum specific O-antigens of typhoid and paratyphoid fever agents were determined by enzyme immunoassay (EIA), radioimmunoassay (RIA), and O-aggregate hemagglutination reaction (O-AHA), serum specific O-antibodies were determined by RDHA, EIA, RIA or O-AHA used during the 1st week of disease were twice as effective as RDHA. Combined use of EIA and O-AHA for the detection of serum specific O-antigens made it possible to diagnose typhoid fever in 90.91%, paratyphoid fever type A in 96.15%, and paratyphoid fever type B in 95.55% of cases.

Antigens, Bacterial↗
PubMed1987

[Determination of serum antibody avidity compared to infectious O-antigenemia in paratyphoid B patients].

The avidity of serum antibodies depending on infectious O-antigenemia in patients with paratyphoid B has been studied in the course of the disease. The study has revealed a faintly pronounced inverse correlation between the degree of avidity of serum antibodies and the level of infectious antigenemia. The avidity of serum antibodies in paratyphoid B has been found to increase in the course of the disease. A significant dependence of the severity of the disease on the avidity of serum antibodies has been noted.

Antibodies, Bacterial↗
PubMed1986

[Determination of antibodies against ribosomes and various cell wall components and detection of circulating antigens of group A Streptococcus in patients with erysipelas].

The level of antibodies to the ribosomes, polysaccharide A and peptidoglycan of group A streptococcus in the blood of patients with primary, secondary, and often relapsing erysipelas was studied by means of the enzyme immunoassay with the use of the sandwich techniques. For control, the sera of healthy donors were used. In the sera obtained from all groups of erysipelas patients a significant rise in the levels of antibodies to ribosomes and peptidoglycan in comparison with the controls was revealed. An increase in the level of antibodies to polysaccharide A was revealed only in patients with frequently relapsing and secondary erysipelas. Depending on the clinical form and the duration of the disease, polysaccharide A was detected in 32-51.9% of erysipelas patients and protein-ribosomal antigen was detected in 28.6-51.9% of such patients.

Antigens, Bacterial↗
PubMed1985

[Determination of antibodies to Streptococcus group A polysaccharide by an immunodiffusion method in human sera in various pathological processes of streptococcal etiology].

A method for the assay of antibodies to the specific antigenic determinant of group A streptococcal polysaccharide (A-polysaccharide) in human sera was developed. The sera were tested in the precipitation test in agar gel with different doses of A-polysaccharide. The presence of a high level of the above-mentioned antibodies is indicative of infection caused by group A streptococcus, but not streptococci of other groups or by the L-forms of streptococci. In 87.5% of patients with primary rheumatism a high level of antibodies to the specific antigenic determinant of A-polysaccharide was detected during the first day of the disease, which confirms most convincingly the etiological role of group A streptococcus in rheumatism. Considerable differences in the level of antibodies to A-polysaccharide in the active and non-active phases of rheumatism have been established, which makes it possible to use the presence of a high level of these antibodies as an indicator of the rheumatic process activity. A considerable percentage of sera with a high level of antibodies to A-polysaccharide was also detected in erysipelas and acute glomerulonephritis patients.

Antibodies, Bacterial↗