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Biomedical subjects

V L Bykov

Publications and source records attributed to V L Bykov.

106 records · Page 6Linked to original sources
PubMedDate not supplied

[Age-related characteristics of the blood supply to the thyroid gland (histochemical and stereological studies)].

Complex histochemical and stereological study of the thyroid gland vessels in A/He mice revealed significant age changes in the organ vascularization, and allowed assessing the dynamics of the relative value of the functioning vessels and of the transport processes activity in the capillary-thyrocyte system at different postnatal ontogenesis stages. There was a low vascularization level the first postnatal days; it increased considerably by the time of sexual maturation, and was followed by a relative stabilization. The organ vascularization decreases with aging chiefly on account of the transport processes reduction in the capillary-thyrocyte system. At the same time, the greatest age variability was characteristic of the relative volume of functioning vessels.

Aging↗
PubMedDate not supplied

Temporal organization of the thyroid gland in A/He mice (morphometric investigation).

Biological rhythms of structural elements of the thyroid gland of A/He mice were studied by morphometric methods followed by spectral amplitude and phase analysis on the Minsk-32 computer. The morphological data show that the activity of the organ is maximal at night. The biorhythms have a complex frequency spectrum, including intradian, circadian, and ultradian components.

Animals↗
PubMedDate not supplied

[A morphofunctional analysis of endocrine gland status in Candida infection].

Morphometric analysis of the thyroid, parathyroid glands and adrenal cortex was carried out in mice with candidiasis. A grave systemic form of candidiasis, that eventuated in the death of the animals, was associated with a reduction of the functional activities of the thyroid and parathyroid glands and a drastic activation of the adrenal cortex. A benign course of the infection was paralleled by a moderate inhibition of the thyroid activity, followed by its activation and normalization. Changes of the parathyroid activity were negligible in such a case, and the adrenocortical activity is moderately growing at the peak of the infection and normalizes later.

Acute Disease↗
PubMedDate not supplied

[Macrophage interaction with Candida albicans in immunodepression].

The interaction of fungi of the species C. albicans with macrophages has been studied in vivo under the conditions of immunosuppression resulting from the action of immunosuppressive agents, belonging to different groups with respect to the chemical nature and mechanism of their action (cyclophosphamide, azathioprine, hydrocortisone acetate, methotrexate, cyclosporin A). The data obtained in this study indicate that under the conditions of immunity disturbances macrophages have decreased functional activity. Azathioprine and cyclosporin A have the greatest inhibiting influence on macrophages during their interaction with fungi, while cyclophosphamide has the least influence.

Animals↗
PubMedDate not supplied

[Dendritic antigen-presenting cells of the oral mucosa in health and in pathological conditions].

Oral mucosa contains a system of dendritic antigen-presenting cells which provide its specific immune defence. These cells are found both in mucosal epithelium and lamina propria and possess specific ultrastructural, cytochemical, immunocytochemical and functional properties. Langerhans cells are the most numerous and well-studied population of antigen-presenting cells in oral mucosa. However, epithelium and lamina propria harbour other types of dendritic cells. Dendritic cells trap antigens process them and provide them to lymphocytes; they also influence other mucosal cell types. This review summarizes recent data on distribution, morphologic and functional characteristics of dendritic antigen-presenting cells of the oral mucosa in health and in some pathological conditions. A possible role of these cells in pathogenesis of some diseases is discussed.

Antigen-Presenting Cells↗
PubMedDate not supplied

[Dendritic antigen-presenting cells of the distal section of the female reproductive tract in normal, experimental and in pathological conditions].

Female lower genital tract (the vulva, vagina and uterine cervix) contains a system of dendritic antigen-presenting cells (APCs) which are the main elements of the afferent limb of its local immune system. These cells are found both in mucosal epithelium and lamina propria and possess specific ultrastructural, cytochemical, immunocytochemical and functional properties. Most numerous and well-studied populations of APCs in female lower genital tract are Langerhans cells which are highly sensitive to hormones and noxious factors. This review summarizes recent data on distribution, morphological and functional characteristics of dendritic APCs in female lower genital tract under normal and experimental conditions and in some pathological states (viral infections, preneoplastic and neoplastic processes).

Antigen-Presenting Cells↗