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Biomedical subjects

V Kumar

Publications and source records attributed to V Kumar.

At least 649 records · Page 36Linked to original sources
PubMed1987

Detection of antigliadin antibodies in bullous diseases and their recognition of similar antigenic polypeptides.

The presence of antigliadin antibodies (AGA) in dermatitis herpetiformis (DH) has been associated with gluten-sensitive enteropathy. Because of the discrepancies in the specificity of AGA, we examined the sera of patients with DH, pemphigus and pemphigoid for AGA both by enzyme immunoassay and by immunofluorescence. Approximately 80-90% of sera of patients with DH had AGA. AGA were not disease-specific, they also occurred in about 40-80% of patients with pemphigus and pemphigoid depending on the method employed. In addition, AGA were also present in normal subjects. The incidence of AGA increased with age. AGA from patients with various bullous diseases recognized the same polypeptides thus suggesting that the presence of AGA cannot be regarded as a serological marker of DH.

Antibody Specificity↗
PubMed1987

Reticulin and endomysial antibodies in bullous diseases. Comparison of specificity and sensitivity.

Reticulin antibodies of IgG- and IgA-class and endomysial antibodies, which are of the IgA class, were studied by indirect immunofluorescence in 30 normal subjects, and in 45 patients with dermatitis herpetiformis (DH), 31 with pemphigoid, and 30 with pemphigus. Endomysial antibodies were present in 65% of patients with DH maintained on a normal diet and were absent in those on a gluten-free diet and in those with other diseases and in normal controls. Reticulin antibodies of the IgA class were disease specific for DH and occurred in only 25% of such patients. IgG-class reticulin antibodies, on the other hand, were not specific for DH, as they occurred in similar frequencies in patients with pemphigoid and pemphigus and in normal subjects. IgA-class reticulin antibodies occurred primarily in those patients with DH who had high titers of endomysial antibodies. None of the 20 such patients who were negative for endomysial antibodies had IgA-class reticulin antibodies. These studies indicate the high degree of specificity and sensitivity of endomysial antibodies.

Dermatitis Herpetiformis↗
PubMed1987

Newer insulins.

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Animals↗
PubMed1987

Application of case management to the control of acute respiratory infections in low-birth-weight infants: a feasibility study.

The feasibility of introducing a case management programme for acute respiratory infections among low-birth-weight infants at the primary health care level was investigated in 37 villages in the Indian state of Haryana. Twenty-one of the villages served as the intervention area, while the remaining 16 formed the control area. All low-birth-weight infants born in the two areas between January 1982 and September 1983 (199 in the intervention area and 211 in the control area) were included in the study. Primary health care workers were contacted in 38% of episodes of acute respiratory infections in the intervention area, in contrast to only 1% of episodes in the control area. Also, the mean duration of infections in the intervention area was significantly lower (P<0.01), while the case fatality was about 33% of that in the control area. The results indicate that the programme can be successfully incorporated into existing primary health care infrastructures.

Acute Disease↗
PubMed1987

Primary lymphoma of the central nervous system: a diagnostic problem.

Primary lymphoma of the central nervous system (CNS) is difficult to diagnose because of the difficulty in differentiating it from multiple sclerosis, sarcoidosis, metastatic disease, chronic granulomatous disease, and cerebral cysticercosis. With the patient presented in this report, no abnormalities were found after performing laboratory tests, using radiographic modalities, and taking biopsies. Dexamethasone treatment was initiated, and patient's symptoms improved.Primary CNS lymphoma was not diagnosed until a year after presentation, due to lack of tissue diagnosis. CNS must be suspected when a diagnosed tumor treated with steroid is not found at surgery. It is suggested that a computerized tomographic scan be requested before the start of steroid therapy, as the lesion can disappear with steroid treatment.

Biopsy↗
PubMed1987

Microarterial pattern of human kidney.

The study of microarterial pattern of human kidney by Butylbuterate and Microfil Silicone Rubber compound cast technique has been carried out. The arcuate arteries and their major intrarenal branches were seen running in the tissue tunnels (the area devoid of glomeruli and capillary plexus) not observed by any other worker in the field. The aglomerular giant arterioles arising from arcuate and interlobar arteries were observed. Afferent arteriole feeds glomerulus and afferent breaks up into capillary plexus. Aglomerular afferents have also been observed. Glomeruli were distributed right underneath the renal capsule. Vasa-recta, from arcuate artery and capillary plexus at the corticomedullary junction were running almost a straight course deep into the medulla unlike the observations of Castelli and Huelke (1968) who noticed the tortuous course. However the present study revealed that the vasa-recta become highly tortuous when they terminate by anastomosing with each other at the apex of the renal papilla. When a major artery pierces through the vasa-recta bundle near corticomedullary junction, the bundle divides into 2 and each half arches round that vessel to continue as a single bundle.

Capillaries↗