[Prevention and epidemiology of post-transfusion hepatitis during the past 10 years].
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Biomedical subjects
Publications and source records attributed to V Krislo.
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The authors describe the application for determining gamma-glutamyl-transpeptidase (GGTP) activity in donors in order to prevent posttransfusion hepatitis. They particularly refer to the high susceptibility of this method for detecting latent and chronic liver diseases virtually unable to be recognized by other methods. Regular GGTP screening having been introduced in the past 4 years, a rapid lowering of the occurrence of posttransfusion hepatitis could be observed. The authors recommend this method of examination as a valuable aid to the prophylaxis of hepatitis transferred by blood preparations.
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The works is based on a previous investigation published in the journal Vnitrní Lékarství, 36, 1990, 8, pp. 759-762. The authors investigated morphological changes of the gastric mucosa and the presence of Campylobacter pylori (CP) in probands with chronic active surface CP positive antrum gastritis one year after treatment with a bismuth preparation (Bismuth citrate 120 mg per capsule made on prescription) for a one-month period 4 capsules per day. This concerned probands with functional dyspepsia without a history of alcohol intake. After a one-year interval eradication of CP persisted in 8 probands (53.3%); in 7 patients (46.7%) there was a relapse of CP positivity. The authors confirmed that CP and active chronic gastritis are associated. Chronic non-specific inflammatory cellulitis persisted after one year with the same intensity in 17 probands (74%), in 6 it increased by one grade (26%). Improvement or complete recovery of the histological finding was not recorded in any of the patients. In the corpus of the stomach the unaltered finding persisted. Morphological changes were always directly proportional to the presence of CP. Its eradication appears to be causal treatment of chronic active surface CP positive antrum gastritis, one of the groups in the wide spectrum of chronic gastritis.