Search PubMed⌕ Search

Biomedical subjects

V Kocandrle

Publications and source records attributed to V Kocandrle.

At least 91 records · Page 5Linked to original sources
PubMed1985

Problems in experimental pancreatic segment transplantation with open duct.

Using in-situ "autotransplantation model" and dogs with allotransplant of pancreatic segment with the open duct, we confirmed the capacity of the canine peritoneum to tolerate the presence of inactive pancreatic juice and to resorb it. However, non-living tissue surrounding the graft may induce activation of pancreatic juice and lead to acute pancreatitis. Diffuse interstitial fibrosis, unaffecting endocrine parenchyma, develops in all autologous and allogenic pancreatic grafts. Reduction of acinose parenchyma probably accounts for the gradual normalization of serum amylase levels. We assume that graft fibrosis is caused by a gradual closure of the pancreatic duct. Diffuse interstitial fibrosis cannot be classified as a rejection change. It antiplatelet drugs are not administered, graft necrosis is caused by splenic artery thrombosis at a low flow rate. In diabetic recipients with antiplatelet therapy both the animal and the graft survivals averaged 22.5 days. All dogs died of complications at a normal glucose metabolism. We hold that at present research should concentrate on vascular complications of pancreatic segment transplantation.

Amylases↗
PubMed1985

The effect of perioperative hydration in allogenic renal graft recipients.

The authors evaluated the effect of perioperative hydration by 20% human albumin, packed red blood cells (RBC) and saline in allogenic renal graft recipients. In the group of recipients selectively hydrated, the incidence of postoperative oligoanuria decreased from the initial 62 to 25.7% compared with 50% in the group of nonhydrated patients. However, in the former group graft ruptures occurred in 10% as against 1.6% only in the latter. Potential causal relation between the higher incidence of ruptures and perioperative hydration has not been demonstrated and will be subject to further study. With respect to the lower risk imposed on the patients with rupture than on those with postoperative oligoanuria (higher survival rate of grafts and lower mortality of patients) the authors recommend routine introduction of body fluid expansion during operation in allogenic renal graft recipients from cadaver donors.

Fluid Therapy↗