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Biomedical subjects

V Knight

Publications and source records attributed to V Knight.

At least 73 records · Page 4Linked to original sources
PubMed1971

Aerosol inoculator for exposure of human volunteers.

The performance of an aerosol inoculator for human volunteers is described in tests that used the PR8 strain of type A influenza virus and sodium fluorescein as a physical tracer. Virus recovery from the aerosols was approximately 1% and was unaffected by such variables as prolonged aerosolization, total airflow, relative humidity, or method of sampling. The recovery of sodium fluorescein from the aerosol was approximately 12% and was influenced by total airflow rates and relative humidity. With this apparatus, it should be possible to deliver reasonably predictable and measurable doses of respiratory viruses to human subjects. The design makes it possible to dismantle the inoculator into its component parts to facilitate portability.

Aerosols↗
PubMed1971

Serological responses and results of natural infectious challenge of recipients of zonal ultracentrifuged influenza A2-Aichi-2-68 vaccine.

In an epidemic of Hong Kong influenza in a penal institution, acute respiratory illness occurred in 5.6% of 196 inmates given single subcutaneous doses of 332, 535, or 1 265 CCA of zonal centrifuged, inactivated vaccine and in 11.7% of 755 nonvaccinated inmates (P<0.03). The frequency of illness among inmates who received single doses of 54 or 137 CCA of vaccine was not significantly different from that among the nonimmunized inmates (chi(2)=0.93, not significant). The vaccine was prepared with the A2/Aichi/2/68 strain of influenza and administered 7 weeks before the outbreak. Virus shedding was significantly lower in vaccinated inmates with respiratory disease (11.1%) than in nonvaccinated inmates (73.7%, P<0.04).Serological studies showed an increasing mean titre and increasing frequency of 4-fold or greater haemagglutination inhibition and neutralizing antibody responses with increasing dosage of vaccine.

Antibody Formation↗