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Biomedical subjects

V Katić

Publications and source records attributed to V Katić.

At least 19 recordsLinked to original sources
PubMed2000

General practitioners' patterns of antimicrobial drugs prescription in the therapy of acute pharyngitis.

OBJECTIVE: To analyse the patterns of antibiotic prescription in the treatment of acute pharyngitis among a group of general practitioners (GPs). DESIGN: From the records of their patients, 11 specialists in general practice have collected post hoc data on their patients and on acute pharyngitis in the period from October 1, 1994 to September 30, 1995. SETTING: 11 teaching practices in four health centres in Zagreb, Croatia. SUBJECTS: GPs grouped according to whether they had pre-school children in their care. MAIN OUTCOME MEASURES: The choice and cost of the prescribed antimicrobial drug, and the impact of the characteristics of the population in care to the prescription rate and structure. RESULTS: An antimicrobial drug was prescribed in 784 (72.1%) cases of pharyngitis. Two groups of GPs have shown significant differences in the prescription rate (p < 0.001), and in the choice of antimicrobial drugs (p < 0.001). CONCLUSION: GPs with a larger number of patients in their care suffering from chronic diseases tend to prescribe antimicrobial drugs more often in the treatment of acute pharyngitis.

Acute Disease↗
PubMed1996

Pierre Robin syndrome: characteristics of hearing loss, effect of age on hearing level and possibilities in therapy planning.

Hearing loss was studied in 22 patients with Pierre Robin syndrome (PRS) aged three to 12 years (median 5.0 years). The results were compared to those obtained in 62 patients with isolated cleft palate (ICP) aged one to 27 years (median 5.5 years). Hearing loss was more frequently found in PRS (73.3 per cent) than in ICP (58.1 per cent) patients (p = 0.02). PRS patients had more ears with moderate (21-40 dB) and severe (> 40 dB) hearing loss, disturbing their social contact, with no tendency to normalization with age (Spearman r = 0.065). In contrast to PRS, ICP patients showed a significant tendency to hearing level normalization with ageing (Spearman r = -0.453; p = 0.001). Planigraphs of temporal bones showed inadequately developed pneumatization of the mastoid bone in all PRS patients and in most ICP patients. No malformation of the inner or middle ear was found in either group. PRS patients have a significantly higher risk of conductive hearing loss than those with ICP. Use of tympanostomy (ventilation) tubes is therapy of choice in patients with Pierre Robin syndrome, and it should be introduced as early as possible, even at the same time as palatoplasty.

Acoustic Impedance Tests↗
PubMed1994

Acute upper respiratory tract infections and indications for tonsillectomy in children. I. Immunoglobulin synthesis in the palatine tonsil tissue.

Current viewpoints and practice concerning indications for tonsillectomy are presented. The annual specific risk for upper respiratory infection in children aged up to 15 is 1.1. The risk is higher in the youngest age group, in whom it rises to 1.8, decreasing with age and being lowest among children aged 12-15 years (0.5). The proportion of tonsillitis among acute upper respiratory tract infections is highest in the age group up to 3 years (36.9%); at the age of 4-5 years it is 37.1%, and is lowest among children aged 12-15 years (21.9%). The risk of tonsillitis caused by streptococci is highest among children aged up to 5 years. Statistical significance of differences in the synthesis of immunoglobulins (G, M, A and sA) and lysozymes in the palatine tonsil tissue of tonsillectomized children and healthy volunteers was tested by non-parametric tests for independent samples. Significant differences of the above mentioned syntheses were found in all entities studied. Any contribution to the documentation on the nature and cause of each tonsillitis in childhood is of great clinical value, because it is the only basis for rational consideration of indications for tonsillectomy.

Acute Disease↗
PubMed1993

Lipid-bound sialic acid, prostaglandin E and histamine in head and neck cancer.

Blood concentration of lipid-bound sialic acid (LBSA), prostaglandin E (PGE) and histamine were determined in 37 patients with carcinoma of hypopharynx and larynx (supraglottic and glottic), in 12 non-cancer patients and in 10 healthy subjects. The concentration of LBSA was significantly increased in 94.4% cancer patients preoperatively and fell to somewhat lower levels within 1 month after tumour resection. In patients with complete tumour resection and no tumour recurrences within 2 years, it steadily decreased thereafter, reaching normal levels within 6-24 months after surgery, whereas in patients with tumour recurrences or incomplete tumour resection it rose again within 6 months after tumour resection. Similarly, the concentration of PGE was significantly increased in about two thirds of cancer patients (67.6%) preoperatively, dropped significantly within 1 month after tumour resection and rose again in patients with tumour recurrences. Preoperative histamine concentration was decreased in 24.3% of cancer patients and postoperatively it rose both in patients with or without tumour recurrences.

Adult↗
PubMed1993

The importance of monitoring colorectal adenomas by tumor markers (ROC analysis).

Are the increased values of specific tumor markers significant in monitoring colorectal adenomas at the beginning of malignant alteration? Tumor markers (CEA, CA 19-9 and CA 72-4) were determined in sera by IRMA kits. The increased levels of tumor markers CEA and CA 19-9 were statistically very significant in patients (28) with colorectal adenomas at the beginning of malignant alteration and in the group with colorectal adenocarcinomas (96). By ROC analysis the sensitivities, positive predictive values and negative predictive values of CEA and CA 19-9 were quite acceptable with high accuracies for all determined tumor markers in colorectal adenomas at the beginning of malignant alteration. Those findings suggest the importance of monitoring of colorectal tumours and precancerouses by tumor markers serum levels and it confirms the usefulness of counting results by ROC analysis.

Adenocarcinoma↗
PubMed1992

Prognostic significance of plasma prostaglandin E concentration in patients with head and neck cancer.

Plasma prostaglandin E (PGE) levels were determined by radioimmunoassay in 53 patients with various stages (II, III, and IV) of hypopharyngeal and laryngeal squamous cell carcinoma, in 12 non-cancer patients and in 10 healthy volunteers. The mean PGE concentration was somewhat higher in non-cancer patients (mean +/- SD = 34.6 +/- 5.37 pg/ml) than in healthy subjects (28.1 +/- 4.96 pg/ml). In spite of a high data variability, the mean preoperative PGE levels in cancer patients were proportional to the stage of the disease and higher than in non-cancer patients (41.2 +/- 19.7 pg/ml, 52.8 +/- 26.7 pg/ml and 82.0 +/- 34.9 pg/ml in stages II, III and IV respectively). The mean plasma PGE concentration significantly decreased for all tumour stages 15-30 days after surgical removal of the tumour, but rose again in some patients within 6-18 months after surgery. The incidence of tumour recurrences 6 and 18 months after surgery was significantly higher in patients with an increased preoperative PGE level (greater than 43.3 pg/ml) than in those patients with a PGE level within the normal range (less than 43.3 pg/ml). The mortality was also higher in the former group, but the difference did not reach the level of significance. Similarly, the mean preoperative and most postoperative concentrations of PGE were significantly higher in patients in whom tumour recurred within 18 months than in tumour-free patients.

Adolescent↗
PubMed1992

Production of prostaglandin E by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue.

The production of prostaglandin E ex vivo was studied in samples of 31 squamous cell carcinomas of the head and neck (SCCHN) and 12 adenocarcinomas of gastrointestinal tract (ACGI). As a control, the PGE production was measured in 22 samples of noninvolved mucosa in patients with SCCHN and 12 samples of gastrointestinal mucosas. The mean PGE production by SCCHN was significantly higher than in normal mucosa. Furthermore, the PGE production by tumors which recurred or spread to regional lymph node within 18 months after surgery was higher than in tumors which did not recur within that interval. Also, production of PGE by noninvolved mucosa was significantly higher in patients in which tumor recurred after surgery than in patients which were tumor free. On the other hand, the mean production of PGE by ACGI was not different from that of normal mucosa. These data show that determination of PGE production might have prognostic significance in SCCHN.

Adenocarcinoma↗
PubMed1992

Biochemical analysis of vocal fold polyps.

Arachidonic acid metabolites (AAm) have important regulatory functions within several areas of otorhinolaryngology: modulation of immune and allergic responses, inflammation, allergy, etc. The aetiology of vocal fold polyps is still obscure as are the possible mechanisms responsible for their forming and developing. The aim of this study was therefore to investigate the relationship between release of prostaglandins (PGE2, PGI2) and tromboxans (TxA2) from vocal fold polyps ex vivo in 21 patients, in comparison to normal airway mucosa. The production of PGE2 by vocal fold polyps was less than in the controls (ng/ml) (0.5 +/- 0.54; n = 21 vs. 1.09 +/- 0.78; n = 21) (p less than 0.05) but higher than in nasal polyps (0.14 +/- 0.11; n = 16) (p less than 0.01). Prostacyclin production by vocal fold polyps (0.99 +/- 0.92) was less than in control mucosa (2.24 +/- 1.93) (p less than 0.01), but higher than by nasal polyps (0.26 +/- 0.14) and less than in controls (0.99 +/- 0.73) (p less than 0.01) or nasal polyps (0.52 +/- 0.04) (p less than 0.01).

Adult↗
PubMed1991

Distribution of structural and trace elements in human temporal bone.

This study was undertaken to evaluate a systematic analysis of mineral and trace elements of individual functionally determined parts of adult temporal bone. Marked differences were observed in basic structural elements (Ca, P, Mg, and Zn) among different bone regions. The more so, molar Ca/P ratio was significantly different in various regions, being highest in the hammer and vestibular regions. Taxonomic analysis revealed specific differences in the mineral ratio between the two petrous bone regions believed to develop from various embryonal bases. According to results, the observed differences in mineral trace element composition of particular regions of human temporal bone might be explained by their developmental specificities and functional adaptation.

Adult↗
PubMed1989

Grimelius' silver method for all types of malignant melanomas.

Various cytologic appearances of malignant melanomas represent a great diagnostic problem in the pathologist's everyday work. The new Pearse concept that the melanoblast/cyte is the APUD cell led the authors to the idea of using Grimelius' silver method, characteristic of APUD cells, in the diagnostic pathologic work of both melanotic and amelanotic malignant melanomas. The results are based on the examination of 20 tumours. All types of malignant melanomas were Grimelius reactive. The blanching by hydrogen peroxidase of Grimelius reactive cells makes this silver reaction specific in the study of melanomas.

Histocytochemistry↗
PubMed1984

The effect of five days calcium chloride treatment on the somatostatin cells of the antral mucosa in white rats.

The effects of a five day treatment with calcium chloride (1 ml 0.11 M CaCl2/100g body weight i.p., twice daily) on somatostatin cells in gastric antral mucosa of white rats were investigated. Somatostatin cells of experimental and control animals were identified by immunoperoxidase method using rabbit antihuman antisomatostatin (1:1000), and counted on perpendicularly cut sections taken from four transversal levels going from pylorus to antrofundic border. The results obtained have demonstrated the occurrence of somatostatin cell hyperplasia in animals treated with calcium chloride, established on the ground of highly significant rise in the number of somatostatin cells and a change in their topography.

Animals↗
PubMed1980

[Secondary metastases after neck dissection (author's transl)].

Hundredfourty-eight patients who underwent three types of neck dissection for cervical lymphadenopathy for squamous cell cancer of the head and neck were analysed retrospectively. In patients with no recurrence of the primary tumour the secondary metastases appeared in 44% after suprachyoid neck dissection, in 33% after classical and in 19% after modified neck dissection.

Carcinoma, Squamous Cell↗