[Changes in the spatial synchronization of the cerebral cortex in mice after elaboration of a defensive conditioned reflex].
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Biomedical subjects
Publications and source records attributed to V K Uteshev.
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Experimental data are presented on the formation and retention during 24 hours of a motor alimentary conditioned reflex (MCR) in a T-maze, in rats 4--5 months and 1,5--2 months old. In adult rats the formation of MCR required a significantly smaller number of runs and less time, than in young ones. In young animals reflex retention is better as compared to adults. Traces of MCR change regularly throughout 24 hours in both animal groups which may be due to development of memory in several stages, in young animals this process being slower.
The characteristics of formation of the reflex of water avoidance in a water maze and the dynamics of its reproduction during 24 hours after its elaboration were studied in mice. In case of incomplete initial learning the reflex reproduction had a phasic, oscillating nature. It is assumed that this oscillating dynamics is due to corresponding changes in the similarity of biopotentials in the cortical areas which participate in the formation of the conditioned connection.
Injury to the hippocamp disturbs learning processes and short-term memory in 20-, 50- and 110-day rats. In 50-day rats, hippocampectomy results in lesser changes in learning and memory than in 20- and 110-day animals. Anatomo-physiological characteristics of the hippocamp in 20-day rats presumably indicate a particular importance of this structure at early stages of ontogenesis, when the brain cortex is not yet sufficiently mature and its connections with other structures are not completely formed. Non-linear dependence of learning disturbance in rats of varying age after hippocampectomy suggests that in rat hippocampal function undergoes changes during individual development of animals.