Results of registration trial of combination vaccine for prevention of hepatitis A and B are presented. The trial was conducted in 5 centers of Russia in 2004-2005 with full accordance to good clinical practice requirements and standards for multicenter open randomized trials. Immunogenicity of studied combination vaccine Twinrix was evaluated in comparison with two simultaneously administered monovalent vaccines against hepatitis A and B (Havrix and Engerix-B) in 200 healthy subjects aged 18-40, which were seronegative to hepatitis A and B. Reactogenicity based on interviewed and non-interviewed symptoms ranged on intensity was assessed also. 1 month after completion of primary vaccination all subjects in both groups were seropositive to hepatitis A. Sero-protection level of antibodies to hepatitis B virus was detected in 98.9% of participants vaccinated with Twinrix and in 95.6% of participants vaccinated with Engerix-B and Havrix. Overall, reactogenicity of vaccines was minor, marked adverse events caused by vaccination were rare (approximately 1%). Study shows that combination vaccine against hepatitis A and B (Twinrix) at least non inferior in terms of immunogenicity, safety and tolerability to monovalent vaccines (Havrix and Engerix-B), were registered in Russia.

Adolescent↗

PubMedDate not supplied

[Control of filariasis in India].

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Filariasis↗

PubMedDate not supplied

[The incidence and control of trachoma in India].

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Child↗

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[The periodic and regional characteristics of the pneumococcal serotype spectrum in children with respiratory diseases and in healthy carriers].

The aim of the work was the comparative study Streptococcus pneumoniae serotypes, isolated from healthy carriers and acute pneumonia patients in different regions of the CIS; in Moscow observations were carried out for 10 years. Specific antibodies to different S.pneumoniae capsular polysaccharide antigens were determined in blood serum samples by the method of heterogeneous enzyme immunoassay. The study revealed that S.pneumoniae serotype spectra in healthy children and in children with acute respiratory viral diseases were similar, while from pneumonia patients with complications of pleuritis caused by S.pneumoniae serotypes 1, 3, 5 and 14, were more frequently isolated. During 10 years of observations changes in the occurrence of individual serotypes were noted both in carriers and in patients. Differences in the serotype spectra of S.pneumoniae isolated in different regions were established. S.pneumoniae serotype 5 caused 70% of pleuritis cases in Tashkent, while rarely occurring in regions with the moderate climate. S.pneumoniae serotype 14, formerly causing complicated forms of pneumonia, lately became more widespread, but at the same time caused fewer cases of pneumonia with complications. High occurrence of pneumonia among children aged 1-3 years correlated with a low level of specific antibodies in the child population.

Antibodies, Bacterial↗