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Biomedical subjects

V K Sologub

Publications and source records attributed to V K Sologub.

At least 19 recordsLinked to original sources
PubMed1995

Alpha-fetoprotein-mediated targeting of anti-cancer drugs to tumor cells in vitro.

An oncofetal protein, human alpha-fetoprotein, was selected as a vector molecule for targeted delivery of antitumor substances. Conjugates of alpha-fetoprotein with doxorubicin, daunomycin, calichemicin, carboxyphosphamide, bleomycetin, chlorbutin, cis-platinum, methotrexate were synthesized. All conjugates displayed a highly selective antitumor cytotoxic activity towards human cell cultures. The optimal alpha-fetoprotein:cytotoxic compound ratio was shown to be 1:3 - 1:5. The results obtained serve as a basis for creating antitumor preparations of a new generation, which are highly selective to tumor cells owing to receptor-mediated endocytosis.

Antineoplastic Agents↗
PubMed1992

Enteral hyperalimentation of burned patients: the possibility of correcting metabolic disorders by the early administration of prolonged high calorie evenly distributed tube feeds.

Metabolic processes and the ways they may be treated were investigated in severely burned patients receiving prolonged high calorie evenly distributed tube feedings. It was shown that in critically ill patients the absorption of nutrients in the upper regions of the intestine was slightly impaired but the ability to absorb was preserved, which made it possible to provide prolonged evenly distributed tube feeding. For these purposes we used the nutrient mixture 'Combustal'. Restoration of nitrogen balance could be reached within about 10 days after starting tube feeding. However, the creatine excretion remained high, a manifestation of increased dystrophy of muscle tissue. Pseudocholinesterase activity in serum was also decreased, suggesting subnormal biosynthetic processes. To provide the full correction to normal of the metabolic processes the tube feeding with 'Combustal' should be given for at least a month.

Adolescent↗
PubMed1990

[Treatment of patients with thermal lesions with ointments on water-soluble base].

Treatment of patients with thermal burns by ointments prepared on a water-soluble base (Dioxidine and Dioxicol) makes it possible to reduce the bacterial dissemination within a short time and prepare the wound for autodermoplasty which, in turn, reduces the danger of the development of infectious complications. In addition to a marked antimicrobial effect, the ointment possess high hydrophobic and hydrophilic properties and do not induce allergic reactions and side effects.

Adult↗
PubMed1990

[The organization of care for burn victims in catastrophes].

The experience in medical care and treatment of burned patients showed that adequate anti-shock infusion therapy can be established only 4-6 hours after the sustained trauma. However, even despite such a delay, many burned patients (75-80%) get well, due to the later adequate complex treatment controlled by experienced burn specialists [correction of combustiologists] in hospital units specially organized and equipped for this category of patients. Within the first 2-4 days after the trauma, it is recommended to distribute major accident victims between different specialized burn units, using specially equipped air and motor transportation vehicles.

Burn Units↗
PubMed1990

[Experimental study of new polymer dressings in the treatment of burn wounds].

Data on the experimental study of a new polymer coverage for treatment of burn wounds are presented in the article. Application of this coverage, which has a tanning and absorbing affect promotes formation of a dry eschar over a burn wound within the first two days after the accident. This allows to perform early chemical necrectomy on the 6-7th day after the accident. Microbiological investigations show that wound dissemination after application of the coverage remains low and is 3.5 +/- 0.1 per. 1.0 g of the tissue.

Administration, Cutaneous↗
PubMed1989

[Characteristics of the wound process in patients with burns treated by tube hyperalimentation].

Time course of burn wound healing was studied in 32 patients with severe thermal trauma during tube hyperalimentation (TH). Similar study was conducted in 20 patients of the control group who did not receive TH. Early inclusion of TH in the complex of therapeutic measures stimulated some of the links of burn wound histogenesis: the formation of the demarcation swelling and rejection of the necrotic tissue occurred sooner, the leucocytic-macrophagal reaction was activated, and granulation and epithelialization processes were intensified. Thus, the use of the TH method in patients with burns makes it possible to conduct active surgical tactics for restoration of the lost skin area successfully as a result of which they recover within a shorter time than the patients of the control group.

Burns↗
PubMed1989

[Algimaf treatment of burns].

Application of algimaf, a new polymeric dressing, in local therapy of burn wounds is conducive to spontaneous epithelization of surface burns and favors effective autodermoplasty in thermal burns. Cytologic studies of the wound discharge and examination of the burn wound microflora qualitative and quantitative composition indicate a high therapeutic efficacy of the dressing.

Anti-Infective Agents, Local↗
PubMed1989

[Morphological characteristics of the healing of burn wounds covered by an activated-charcoal tissue dressing].

Activated-charcoal cloth and dressings product based upon this material were applied for covering burn wounds. As a control served a gauze dressings with greases and solution topical drugs. The healing of deep thermal burns of 3rd degree on rabbits studied by a histological method was differed by a rapid decreasing of inflammation reaction, active epithelialization and soft scar formation. A clinical use in 15 burned patients was shown that in combination with enzymatic and antimicrobial drug solutions these materials accelerate healing and epithelialization of superficial burn wounds and improve treatment of deep burn wounds before autodermoplasty.

Animals↗
PubMed1987

[Blood phospholipases in burn shock].

The activity of blood plasma phospholipases A and C has been observed during burn shock periods in patients with severe burns affecting more than 20% of the body surface. It was experimentally demonstrated that the enzyme plasma activity increased 30 minutes after burning. Simultaneously, intensification of lipid peroxidation took place. Phospholipases are suggested to liberate from the damaged tissues with their following activation by free-radical products.

Animals↗
PubMed1987

[Treatment of frostbite].

The article shows that treatment of frostbites in a special medium with controlled temperature and humidity makes the time of treatment shorter and prevents complications characteristic of such a trauma. The main purpose of such exposures of the injured areas is to achieve mummification and to make the operation as early as possible. The mummification of the soft tissues began within 5-8 days after trauma. Chemical necrectomy was possible on the 7th-9th days, followed by autodermoplasty on the 2nd day.

Combined Modality Therapy↗