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Biomedical subjects

V K Sethi

Publications and source records attributed to V K Sethi.

32 records · Page 2Linked to original sources
PubMed1982

Thyrotoxicosis and thyroid cancer.

It is generally held that thyroid cancer is uncommonly associated with thyrotoxicosis. We report here nine patients with thyroid cancer amongst 720 patients with thyrotoxicosis. Three patients presented with features of malignancy together with thyrotoxicosis (Group A), one of whom had triiodothyronine (T3)-toxicosis. The remaining six patients were diagnosed following histological examination of tissues removed during subtotal thyroidectomies for hyperthyroidism (Group B). Two patients in Group A had follicular carcinoma; the rest were papillary in type. All the patients were rendered euthyroid initially, followed by ablative therapy for two patients in Group A and four patients in Group B. All but one are alive after one to nine years (mean of 3 . 4 years). The diagnosis of thyroid carcinoma is infrequently considered in the presence of thyrotoxicosis. The association is not clinically apparent in the majority of patients. The optimum management of such occult malignancies in thyrotoxicosis remains to be defined.

Adenocarcinoma↗
PubMed1981

Thyroid scanning & the significance of the solitary cold nodule.

Since thyroid scanning was introduced in Singapore in 1968 there has been progressive increase in the demand for these scans. 215 patients comprising 153 females and 62 males were scanned in 1976 using 131I. The solitary nodule was the commonest condition referred for scans (60%) and next was the multinodular goitre 919%). Other indications for scan included postthyroidectomy cases, aberrant thyroids, retrosternal goitres, thyrotoxicosis and metastases from thyroid carcinoma. 73 cases of solitary cold nodules were discovered and 43 of these were operated on. 7 of these were found to be malignant, giving an incidence of 16%. The incidence of malignancy in the cold nodule varies in the reported literature. By itself the 131I scan cannot diagnose malignancy but is it a useful supplementary test in addition to the clinical and other investigations.

Adult↗
PubMed1981

Non-surgical treatment of thyroid carcinoma.

Thyroid carcinoma, as a rule, is a slow growing tumour and overall results are good. However, the failure to control the primary tumour in a high percentage of patients makes it necessary that adequate, appropriate treatment be given at the first opportunity. Surgery, radiotherapy, radioiodine, hormones and chemotherapy all have a role to play. It is recommended that combination treatment should be used whenever possible. A treatment strategy is outlined. Generally, for differentiated carcinoma, the younger the patient at the time of diagnosis, the better the prognosis.

Adenocarcinoma↗
PubMed1968

"Compound-naevus".

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Child, Preschool↗