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Biomedical subjects

V K Khugaeva

Publications and source records attributed to V K Khugaeva.

At least 19 recordsLinked to original sources
PubMed1995

[The effect of the alpha-adrenoblocker tropafen on the microcirculation and the hematocrit index in the capillaries of rats with ischemia].

The ischemia-induced decrease of the hematocrit index was the greatest in precapillaries and smallest capillaries. Significant oscillations of the index occurred in reperfusion. Tropafen decreased the index. Applied prior to ischemia, tropafen did not affect microcirculation and redistribution of erythrocytes during ischemia and reperfusion.

Adrenergic alpha-Antagonists↗
PubMed1995

[Microcirculatory disorders in cerebral ischemia in rats and their correction by using leu-enkephalin].

Leu-enkephalin (LE) induced mainly a constriction of pial arterioles, diameter of the venules did not change. The effect of the LE involved preservation of the cerebral blood flow and that in microvessels, constriction of some arterioles and reduced dilatation against the background of decreased arterial pressure, bradycardia, increased lymphatic flow and survival of the animals during first hours of occlusion of common carotid arteries.

Animals↗
PubMed1991

[Disorders of cerebral blood flow in ischemia and correction by leu-enkephalin].

The cortical blood flow of the rat brain was decreased at 44% by the bilateral occlusion of common carotid artery. The intraperitoneal injection of the leu-enkephalin before and after ischemia restored the blood flow and increased the volume of the lymph in ductus thoracicus. Cerebrovascular action of leu-enkephalin was connected with its lymphostimulating activity and vasodilation.

Animals↗
PubMed1991

[Effects of an inhibitor of gastric secretion from k-casein on micro-lymphocirculation in the mesentery of the small intestine and intestinal motility in rats].

The casein inhibitor of gastric secretion, when applied to the mesentery of anesthetized rat at doses 0.01-10.0 micrograms in 0.1 ml activated the lymph flow due to enhanced contraction of lymphatic microvascular wall and valves. Moreover, casein inhibitor administrated intraintestinally at doses 5 mg in 0.5 ml on rat keep its lymphotropic activity.

Animals↗
PubMed1990

[Participation of agonists and antagonist of opiate receptors in the regulation of contractile activity of lymphatic microvessels of the rat mesentery].

The contractile activity of the wall and valve of lymphatic microvessels (LM) of the rat mesentery were studied biomicroscopically by optic photometry. Opioid peptides-Leu-enkephalin and dalargin-stimulated LM. Preliminary application of naloxone on the LM prevented the appearance of the LM contractions following the Leu-enkephalin-application. Naloxone did not inhibit contractions of LM previously activated by Leu-enkephalin. It is supposed that opioid mechanisms are involved in the regulation of the LM contractile activity.

Animals↗
PubMed1988

[Effect of dalargin on blood and lymph microcirculation].

Dalargin (a synthetic analog of leu-enkephalin), when applied to the microvessel surface or administered intramuscularly at doses 0.004-40.0 micrograms/kg increased the permeability of the rat mesenteric microvascular wall and activated the lymph flow due to enhanced contraction of lymphatic microvascular wall and valves. Moreover, Dalargin evoked leukocyte migration from venules and activated the intestinal muscular contractions.

Animals↗
PubMed1987

[Blood flow and hematocrit in the microvessels during ischemia].

Intravital studies of microcirculation and packed-cell volume in microvessels of rat mesentery demonstrated changes in the direction of the flow and packed-cell volume in the course of 17 minutes' ischemia caused by the occlusion of the afferent arteriole. Deficient inflow to the ischemized region is at first compensated for by the inflow from other microvessels via major anastomoses and later by retrograde flow through the peripheral branches of the occluded arteriole. The development of generalized microcirculatory disorders is preceded by capillary retrograde flow containing venular blood.

Animals↗
PubMed1986

[Redistribution of erythrocytes in the rat mesenteric microcirculation during reperfusion following short-term ischemia].

The erythrocyte redistribution in the rat mesentery microvessels and the development of postischemic microcirculatory disturbances were influenced by the thrombosis in narrow parts of arterioles and the increase in leukocyte adhesion to venule walls obstructing the blood outflow. The presence of branches and anastomoses in microvascular bed had a pronounced effect on reperfusion disturbances.

Animals↗
PubMed1986

[Reactions of the microcirculatory bed to transient ischemia].

Short-term ischemia on the microvascular level in the rat intestine mesentery was induced by occlusion of the a. mesenterica superior or regional supplying arteriole for 1 or 10 min. No substantial disturbances of blood flow velocity and hematocrit occurred in microvessels after 1 min occlusion, whereas the blood flow cessation for 10 min was followed by a decrease of flow velocity in microvessels under study and development of thrombosis at the site of arteriole occlusion.

Animals↗