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Biomedical subjects

V K Das

Publications and source records attributed to V K Das.

32 records · Page 2Linked to original sources

Plasma renin activity in children after surgical relief of hydronephrosis.

Blood pressure and supine plasma renin were measured in fourteen children aged seven to eighteen years whose hydronephrosis had been relieved surgically two to eleven years previously. Values did not differ significantly from age matched controls. It has been suggested that renal ischemia may persist after relief of hydronephrosis but our results show that hyperreninemia rarely occurs within two to eleven years of effective surgery. Further studies of blood pressure and renin after this period of time remain to be done.

Adolescent↗

Calcitonin cells and unusual follicle in four month old wistar rats.

1. The thyroid gland of 4 month old Wistar rats (both sexes) were made into serial sections and investigated by means of haematoxylin-eosin, PAS-haematoxylin, Davenport's silver impregnation and lead haematoxylin stainings. Calcitonln (C) cells are easily discernible by these techniques. 2. These cells are unevenly distributed and randomly concentrated in the thyroid. They are completely absent from cephalic and caudal poles of thyroid and are generally present in its middle region. They are scare in peripheral follicles and plentiful among central follicles. 3. The isthmus and the parathyroid are completely devoid of C cells. 4. Secretory granules in these cells have a tendency to concentrate towards vascular pole. 5. The unusual follicle is lined by squamous cells and filled with desquamated cells. C cells are completely absent from its epithelial lining.

Animals↗

Calcitonin cells and unusual follicles of the thyroid of the indian grey mongoose, Herpestes edwardsi (Geoffroy).

Histological preparations of thyroid, parathyroid and thymus glands of Herpestes edwardsi were examined for calcitonin cells. They reveal that (1) the thyroid calcitonin cells are oval, rounded and rarely elongated in shape; these cells and their nuclei are distinctly larger than those of the follicular cells and their nuclei; (2) calcitonin cells are unevenly distributed in the thyroid, with the result that certain portions of the thyroid are completely devoid of these cells; (3) on an average, calcitonin cells are in a ratio of 10-15 cells/100 follicular cells; (4) the parathyroid and thymus glands do not display calcitonin cells, and (5) the thyroid gland displays unusual follicles of two categories, (a) follicles with ciliated epithelial cells and (b) follicles with squamous epithelium.

Animals↗

Effect of a calcium rich environment on the ultimobranchial gland of Rana tigrina.

Thirty two specimens of Rana tigrina were divided into four equal groups : group I = controls; group II = injected with Vitamin D2 and placed in a 0.8% aqueous solution of CaCl2; group III = injected with Vitamin D2 and kept in tap water; group IV = placed only in a 0.8% CaCl2 solution. The experimental specimens exhibited varying degrees of hyperactivity of their ultimobranchial gland. Specimens from all the groups were X-rayed. The experimental ones showed different intensity of calcium deposit in their paravertebral lime sacs. The results indicate that prolonged challenge of high calcium induces hyperactivity of the ultimobranchial gland to produce larger quantity of calcitonin, to counteract the experimental hypercalcemia.

Animals↗

Hepatoblastoma.

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Carcinoma, Hepatocellular↗

Thyroid calcitonin cells and parathyroid gland of the Indian rhesus monkey Macaca mulatta in response to experimental hypercalcaemia.

Rhesus monkey (Macaca mulatta) were subjected to hypercalcaemia by daily intramuscular injections of vitamin D2 (100,000 IU) and by providing them gram soaked in 1% CaCl2 solution for eating and 1% CaCl2 solution (prepared in tap water) for drinking. After 10, 15, 20 and 30 days of such treatment the serum calcium level recorded a rise (18.24 +/- 0.56, 26.20 +/- 1.30, 17.25 +/- 0.25 and 20.50 +/- 0.55 mg/dl respectively) as compared to those of control animals (12.80 +/- 1.00, 12.30 +/- 0.50, 12.70 +/- 0.20 and 12.30 +/- 0.30 mg/dl). Serial sections of thyroid parathyroid complex and isthmus were subjected to selective staining for lcalising the C cells. The structure and behaviour of these cells both under normal and experimental conditions has been studied. Hypercalcaemia resulted in the increase of these cells. Mitotic figures of the C cells were also encountered after 10 days of hypercalcaemia. The specimens subjected to 30 days treatment showed complete degranulation of these cells. Chronic hypercalcaemia inhibits the activity of parathyroid cells which display degenerative changes. The anterior and posterior poles, the peripheral regions of thyroid and isthmus are completely devoid of calcitonin cells.

Adult↗