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Biomedical subjects

V Jasonni

Publications and source records attributed to V Jasonni.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Correlations between exhaled nitric oxide levels and pH-metry data in asthmatics with gastro-oesophageal reflux.

BACKGROUND: In gastro-oesophageal reflux (GER), micro-aspirations of gastric fluid may damage the epithelial surface of the airways, an important source of endogenous nitric oxide (NO). OBJECTIVES: The aim of the study was to evaluate the possible influence of GER on fractional exhaled nitric oxide (FE(NO)) release. METHODS: FE(NO) levels were compared in two age-matched groups of allergic children: (1) 20 with mild asthma, responding to standard anti-asthma pharmacologic therapy (asthmatic children) and (2) 12 with mild 'asthma-like symptoms' and GER. RESULTS: No differences in pulmonary functions parameters (FEV(1), FVC and FEF(25-75%)) were found between the two groups of children (p > 0.1); FE(NO) levels were higher in asthmatic children compared with GER children (p = 0.0001). GER children underwent 24-hour oesophageal pH-metry, and possible correlations between pH-metry data, pulmonary functions and FE(NO) levels were evaluated. No correlations were found between pulmonary functions and pH-metry data (p > 0.05, each correlation). In contrast, correlations were observed between FE(NO) levels and pH-metry data, including (1) percentage of study time with pH < 4 (r = -0.80, p = 0.008), (2) number of episodes with pH < 4 (r = -0.76, p = 0.012), and (3) number of episodes >5 min with pH < 4 (r = -0.69, p = 0.02). CONCLUSIONS: Thus, FE(NO) levels are lower in allergic children with 'asthma-like symptoms' and GER as compared to asthmatic children. The correlations between FE(NO) levels and pH-metry data suggest that inhalation of acid gastric content may interfere with NO production in the airways.

Asthma↗
PubMedDate not supplied

[Nephroblastoma presenting with massive hematuria may require emergency surgery].

About 20% of children with nephroblastoma at onset present with macroscopic haematuria, which is usually asymptomatic and of little clinical relevance. The Authors describe an unusual case of nephroblastoma presenting with massive haematuria causing extensive blood clothing along the urinary tract and bladder. The phenomenon was of such entity to determine urinary retention and induce performing emergency nephrectomy. Tumour resection was radical and postoperative course uneventful. Eighteen months after surgery patient is in excellent status and full remission.

Emergencies↗