Biomedical subjects

V J Robinson

Publications and source records attributed to V J Robinson.

20 records · Page 2Linked to original sources

PubMedDate not supplied

A complete proton and carbon-13 NMR analysis of fluocinonide, a fluorinated corticosteroid.

This paper presents a complete analysis of the proton and carbon-13 NMR spectra of 21-acetoxy-6 alpha,9-difluoro-11 beta-hydroxy-16 alpha,17-(1-methylethylidene) bis-(oxy) pregna-1,4-diene-3,20-dione, a potent anti-inflammatory fluorosteroid. The 300 MHz proton spectrum was analyzed using a combination of the two-dimensional homonuclear chemical shift correlation (COSY) technique and one-dimensional NOE difference spectra. Exact coupling constants and chemical shifts were obtained by spectral simulation and iteration. The carbon-13 spectrum was assigned from the proton spectrum via a two-dimensional heteronuclear chemical shift experiment, and long-range fluorine-proton couplings were confirmed by a fully coupled heteronuclear COSY-type experiment.

Chemical Phenomena↗

PubMedDate not supplied

Is real-time quality assessment of health care an achievable goal?

Hospital-wide and real-time clinical outcome evaluation systems promote optimal quality of care with contained costs. These measurements of achieved health care benefits are critical for the ongoing process of national health care improvement. A practical hospital-wide quality improvement method, developed in the Veterans Administration Medical Center-Salt Lake City (VAMC-SLC), that evaluates positive, neutral, and negative outcome in relation to the mutual interactions between the health care provider, equipment, methodology, and patient is discussed. Real time or retrospective application of this analytical template to high risk procedures generates patient, practitioner, equipment, and methodology specific data to coordinate hospital-wide continuous quality improvement and cost containment efforts. It also allows system-wide comparative assessments of progress in the achievement of benefits within the national health care plan.

Cost Control↗