Biomedical subjects
V J Marmion
Publications and source records attributed to V J Marmion.
The death of Claudius.
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Vascular resistance in primary open angle glaucoma.
PURPOSE: To explore any difference in vascular resistance between normal and glaucoma subjects using a continuous wave Doppler technique. METHOD: The Resistance Index, RI, was calculated in two orbital vessels of 20 glaucoma patients all of whom had pressures over 23 mmHg and 15 age matched normal subjects. The haemodynamic relationship between the supratrochlear and a vessel at the optic disc, presumed central retinal artery, is expressed as RIST/RICRA. RESULTS: In 30 normal eyes the ratio was >1 m, in 10 glaucoma patients it was >1. In those glaucoma eyes which were <1, 14 improved after treatment to >1. The remaining 16 eyes which showed no change in the ratio were the eyes with moderate to severe field loss. CONCLUSION: An altered, increased, peripheral vascular resistance with reduced diastolic flow in small orbital vessels has been demonstrated in glaucoma subjects. This was not altered by treatment in the more severely affected eyes.
The Roman oculist stamps.
Roman Oculist stamps testify to an active practice in the treatment of eye disease during the period of the Roman Empire. They demonstrate a classification of ocular disease, a system of treatment and reveal the names of practitioners.
The sight test fee: effect on ophthalmology referrals and rate of glaucoma detection.
OBJECTIVE: To assess changes, if any, in the numbers of referrals and outcome of glaucoma referrals to the hospital eye service since the introduction of the sight test fee on 1 April 1989. DESIGN: Review of referral records and clinical notes. SETTING: Referrals to the Bristol Eye Hospital. SUBJECTS: 51,919 patients referred to the Bristol Eye Hospital between 1984 and 1992. 9438 case notes of patients referred between 1987 and 1991 were examined in detail. MAIN OUTCOME MEASURES: Numbers of referrals; rate of adult true positive glaucoma referrals. RESULTS: Referrals to the Bristol Eye Hospital were between 13.7% and 19.0% fewer than expected after the introduction of the sight test fee. True positive glaucoma referrals were reduced by the same proportion. CONCLUSIONS: The numbers of patients being identified as requiring treatment or follow up for potentially blinding glaucoma have declined by nearly one fifth since the introduction of the sight test fee. An increased prevalence of preventable blindness may result.
Strategies in Doppler ultrasound.
A computer based system integrating a continuous wave 10 MHz Doppler ultrasound system with a standardising electrocardiographic record has been developed and tested. Data storage and duplication are intrinsic elements in the system which also includes on line analysis of the data. The electrocardiograph permits exact timing and standardisation of the pulse wave forms. The results can be displayed and printed. The controlled data provides a valid basis for comparison. Data obtained from patients suffering from amaurosis fugax are presented and discussed.
The Bristol Eye Hospital--an historical perspective.
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Vascular hypotension and bradycardia following intraocular injection of acetylcholine during cataract surgery.
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Doppler ultrasound as an adjunct for the investigation of amaurosis fugax.
This study demonstrates the ability of Doppler ultrasound using both a simple Doppler technique and Duplex scanning to identify lesions at the carotid bifurcation. The procedure is non-invasive and is of little discomfort to the patient. Doppler ultrasound provides a sound basis for clinical evaluation of vascular disease.
The role of beta blockers in open angle glaucoma.
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Trends in ocular therapeutics.
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The colour vision deficiency in open angle glaucoma. A comparison of tests.
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Chronic progressive external ophthalmoplegia.
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Pilocarpine administration by contact lens.
A previous investigation had indicated that pilocarpine delivered to the eye by means of a hydrophilic contact lens provided better control of the intraocular pressure over a longer period and with a smaller concentration of pilocarpine. To clarify the situation further, an animal experiment was undertaken with radioactive labelled pilocarpine. Three situations were compared: pilocarpine administered by a contact lens, by drops, and by subconjunctival injection. The results indicated that the contact lens gave a greater concentration of the pilocarpine in the iris and ciliary body than either the drops or the subconjunctival pilocarpine. A high concentration of pilocarpine was achieved in the conjunctiva with drop administration and was comparable to that of subconjunctival administration.
Clinical comparative pressure studies with Goldmann; Mackay-Marg and pneumatic applanation tonometers.
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Rapid pneumatic and Mackey-Marg applanation tonometry to evaluate the postural effect on intraocular pressure.
A postural study was conducted in three separate groups of subjects. The first group comprised 20 women volunteers with an average age of 20-75 years. In this group, the study was conducted by the pneumatonograph only. Mean pressure recorded was 15-65 +/- 0-25 mmHg and there was an average rise of 1-4 mmHg in supine posture. Groups 2 and 3 comprised 151 non-glaucomatous and 108 glaucomatous eyes respectively in the age range of 30 to 85 years. In these two groups, the study was conducted using the PTG and the Mackay-Marg tonometer. Clinical evaluation of the Mackay-Marg with the PTG gave significant correlation, with mean Mackay-Marg readings being 1-13 mmHg higher. The intraocular pressure when changing from seated to the supine position increased on average by 2-71 and 4-04 mmHg, respectively in Groups 2 and 3 and by 2-51 and 3-72 mmHg by Vackay-Marg, suggesting a higher change in glaucomatous subjects. Pressure on resumption of sitting was found to be lower than the initial pressure. Postural change also showed some direct relationship with age in non-glaucomatous subjects.
A clinical evaluation of the applanation pneumatonograph.
The applanation pneumatonograph combines pneumatic and electronic systems. It is used for measuring intraocular pressure, aqueous humour dynamics, and ocular pulsation. In the present study the PTG and the Goldmann tonometer have been used to measure the intraocular pressure in 40 normal and 40 glaucomatous eyes. It has been found that the results of the two instruments correlate well. The PTG readings have, generally, been found to be higher with a mean difference of 0-75 mmHg in the normal and 1-25 mmHg in the glaucomatous eye. The mean ocular pulse as determined in normal eyes was 3-25 +/-0-21 mmHg.